Featured Research

from universities, journals, and other organizations

Pancreatic tumor-induced gene may prove beneficial as a drug marker

Date:
April 28, 2014
Source:
Federation of American Societies for Experimental Biology (FASEB)
Summary:
A new mouse model helps scientists better understand the progression of pancreatic cancer and may provide new avenues for the development of therapies, researchers report. Cancer of the pancreas, with a 5% survival rate within five years of diagnosis, is the fourth leading cause of cancer related deaths. The main reason behind such high morbidity is poor early detection capabilities as well as inability of currently employed drugs to alleviate cancer progression.

Cancer of the pancreas, with a 5% survival rate within five years of diagnosis, is the fourth leading cause of cancer related deaths. The main reason behind such high morbidity is poor early detection capabilities as well as inability of currently employed drugs to alleviate cancer progression. Efforts aimed at finding better drug regimens would therefore greatly benefit from a mouse model with an intrinsic marker that can indicate different stages of pancreatic tumor formation leading to cancer and reflect the effects exerted by novel drug candidates.

The research group of Associate Professor Dr. Thomas M. Wilkie at UT Southwestern Medical Center in Dallas, Texas has been characterizing the expression of a gene called Rgs16, short for Regulator of G-protein Signaling 16, in mouse pancreas for some time. His group previously showed its embryonic activation in pancreatic stem cells. Recently, teaming up with co-investigator Associate Professor Dr. Rolf A. Brekken, they looked into its possible involvement in Pancreatic Ductal Adenocarcinoma (PDA), the most common form of pancreatic cancer, in a mouse model with an early onset aggressive form of tumor development. Using a fluorescent protein to detect Rgs16 expression, the investigators found that this gene is induced by pancreatic tumor formation starting from its earliest manifestation as ductal neoplasm all the way to advanced solid tumor in a spatially and temporally coincidental manner. Exploiting the clarity and intensity of fluorescence, postdoctoral fellow Dr. Ozhan Ocal in Dr. Wilkie's group was able to represent images of pancreatic Rgs16 expression, and hence all the stages of pancreatic tumor development, quantitatively. This helped them not only lay out the progression of the disease explicitly, but also opened up a new avenue: testing drug effects on tumor growth.

Currently, chemotherapeutic intervention of pancreatic cancer is still ineffective to extend life span beyond several months. Consequently, many research groups are in hot pursuit of finding new drug targets and designing novel ones against the disease. Utilization of PDA marker Rgs16 is an exciting opportunity as it introduces a low cost and simple test environment to follow and compare the effects of different drugs with various mechanisms of action. Consequently, the use of such a marker suggests a new strategy to screen novel therapeutics in a rapid and efficient manner directly in the tumorigenic mouse.

Currently, Dr. Ocal is trying to find the best combination of available drugs that generates the largest reduction in tumor growth early on. In addition to discovering new therapeutics combinations, principal investigator Dr. Wilkie also hopes to gain insight from additional mouse models about what specific pancreatic signaling pathway Rgs16 might be acting on.

Dr. Ocal presented the findings during the Experimental Biology 2014 meeting on Monday, April 28.

The study was funded by the National Cancer Institute, the National Institute for General Medical Sciences, and a University of Texas Southwestern Cancer Center Pilot Project Award.


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology (FASEB). Note: Materials may be edited for content and length.


Cite This Page:

Federation of American Societies for Experimental Biology (FASEB). "Pancreatic tumor-induced gene may prove beneficial as a drug marker." ScienceDaily. ScienceDaily, 28 April 2014. <www.sciencedaily.com/releases/2014/04/140428163643.htm>.
Federation of American Societies for Experimental Biology (FASEB). (2014, April 28). Pancreatic tumor-induced gene may prove beneficial as a drug marker. ScienceDaily. Retrieved August 27, 2014 from www.sciencedaily.com/releases/2014/04/140428163643.htm
Federation of American Societies for Experimental Biology (FASEB). "Pancreatic tumor-induced gene may prove beneficial as a drug marker." ScienceDaily. www.sciencedaily.com/releases/2014/04/140428163643.htm (accessed August 27, 2014).

Share This




More Health & Medicine News

Wednesday, August 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WHO Calls for Ban on E-Cigarette Sales to Minors

WHO Calls for Ban on E-Cigarette Sales to Minors

AFP (Aug. 26, 2014) The World Health Organization called Tuesday on governments should ban the sale of e-cigarettes to minors, warning that they pose a "serious threat" to foetuses and young people. Duration: 01:44 Video provided by AFP
Powered by NewsLook.com
Have You Ever Been 'Sleep Drunk?' 1 in 7 Has

Have You Ever Been 'Sleep Drunk?' 1 in 7 Has

Newsy (Aug. 26, 2014) A study published in the journal "Neurology" interviewed more than 19,000 people and found 15 percent suffer from being "sleep drunk." Video provided by Newsy
Powered by NewsLook.com
Does Medical Marijuana Reduce Painkiller Overdose Deaths?

Does Medical Marijuana Reduce Painkiller Overdose Deaths?

Newsy (Aug. 26, 2014) A new study found fewer deaths from prescription drug overdoses in states that have legalized medical marijuana. But experts disagree on the results. Video provided by Newsy
Powered by NewsLook.com
Official: British Ebola Sufferer Receiving Experimental Drug

Official: British Ebola Sufferer Receiving Experimental Drug

AFP (Aug. 26, 2014) A British nurse infected with Ebola while working in Sierra Leone is being given the same experimental drug used on two US missionaries who have recovered for the disease, doctors in London say. Duration: 00:44 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins