Featured Research

from universities, journals, and other organizations

Pancreatic tumor-induced gene may prove beneficial as a drug marker

Date:
April 28, 2014
Source:
Federation of American Societies for Experimental Biology (FASEB)
Summary:
A new mouse model helps scientists better understand the progression of pancreatic cancer and may provide new avenues for the development of therapies, researchers report. Cancer of the pancreas, with a 5% survival rate within five years of diagnosis, is the fourth leading cause of cancer related deaths. The main reason behind such high morbidity is poor early detection capabilities as well as inability of currently employed drugs to alleviate cancer progression.

Cancer of the pancreas, with a 5% survival rate within five years of diagnosis, is the fourth leading cause of cancer related deaths. The main reason behind such high morbidity is poor early detection capabilities as well as inability of currently employed drugs to alleviate cancer progression. Efforts aimed at finding better drug regimens would therefore greatly benefit from a mouse model with an intrinsic marker that can indicate different stages of pancreatic tumor formation leading to cancer and reflect the effects exerted by novel drug candidates.

The research group of Associate Professor Dr. Thomas M. Wilkie at UT Southwestern Medical Center in Dallas, Texas has been characterizing the expression of a gene called Rgs16, short for Regulator of G-protein Signaling 16, in mouse pancreas for some time. His group previously showed its embryonic activation in pancreatic stem cells. Recently, teaming up with co-investigator Associate Professor Dr. Rolf A. Brekken, they looked into its possible involvement in Pancreatic Ductal Adenocarcinoma (PDA), the most common form of pancreatic cancer, in a mouse model with an early onset aggressive form of tumor development. Using a fluorescent protein to detect Rgs16 expression, the investigators found that this gene is induced by pancreatic tumor formation starting from its earliest manifestation as ductal neoplasm all the way to advanced solid tumor in a spatially and temporally coincidental manner. Exploiting the clarity and intensity of fluorescence, postdoctoral fellow Dr. Ozhan Ocal in Dr. Wilkie's group was able to represent images of pancreatic Rgs16 expression, and hence all the stages of pancreatic tumor development, quantitatively. This helped them not only lay out the progression of the disease explicitly, but also opened up a new avenue: testing drug effects on tumor growth.

Currently, chemotherapeutic intervention of pancreatic cancer is still ineffective to extend life span beyond several months. Consequently, many research groups are in hot pursuit of finding new drug targets and designing novel ones against the disease. Utilization of PDA marker Rgs16 is an exciting opportunity as it introduces a low cost and simple test environment to follow and compare the effects of different drugs with various mechanisms of action. Consequently, the use of such a marker suggests a new strategy to screen novel therapeutics in a rapid and efficient manner directly in the tumorigenic mouse.

Currently, Dr. Ocal is trying to find the best combination of available drugs that generates the largest reduction in tumor growth early on. In addition to discovering new therapeutics combinations, principal investigator Dr. Wilkie also hopes to gain insight from additional mouse models about what specific pancreatic signaling pathway Rgs16 might be acting on.

Dr. Ocal presented the findings during the Experimental Biology 2014 meeting on Monday, April 28.

The study was funded by the National Cancer Institute, the National Institute for General Medical Sciences, and a University of Texas Southwestern Cancer Center Pilot Project Award.


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology (FASEB). Note: Materials may be edited for content and length.


Cite This Page:

Federation of American Societies for Experimental Biology (FASEB). "Pancreatic tumor-induced gene may prove beneficial as a drug marker." ScienceDaily. ScienceDaily, 28 April 2014. <www.sciencedaily.com/releases/2014/04/140428163643.htm>.
Federation of American Societies for Experimental Biology (FASEB). (2014, April 28). Pancreatic tumor-induced gene may prove beneficial as a drug marker. ScienceDaily. Retrieved September 17, 2014 from www.sciencedaily.com/releases/2014/04/140428163643.htm
Federation of American Societies for Experimental Biology (FASEB). "Pancreatic tumor-induced gene may prove beneficial as a drug marker." ScienceDaily. www.sciencedaily.com/releases/2014/04/140428163643.htm (accessed September 17, 2014).

Share This



More Health & Medicine News

Wednesday, September 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Artificial Sweetener Could Promote Diabetes

Artificial Sweetener Could Promote Diabetes

Newsy (Sep. 17, 2014) Doctors once thought artificial sweeteners lacked the health risks of sugar, but a new study says they can impact blood sugar levels the same way. Video provided by Newsy
Powered by NewsLook.com
Ebola Vaccine Trial Gets Underway at Oxford University

Ebola Vaccine Trial Gets Underway at Oxford University

AFP (Sep. 17, 2014) A healthy British volunteer is to become the first person to receive a new vaccine for the Ebola virus after US President Barack Obama called for action against the epidemic and warned it was "spiralling out of control." Duration: 01:02 Video provided by AFP
Powered by NewsLook.com
Obesity Rates Steady Even As Americans' Waistlines Expand

Obesity Rates Steady Even As Americans' Waistlines Expand

Newsy (Sep. 17, 2014) Researchers are puzzled as to why obesity rates remain relatively stable as average waistlines continue to expand. Video provided by Newsy
Powered by NewsLook.com
President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins