Featured Research

from universities, journals, and other organizations

Fast-acting antidepressant appears within reach

Date:
April 30, 2014
Source:
Federation of American Societies for Experimental Biology (FASEB)
Summary:
In mice, a drug produces evidence of a mood lift within 24 hours and then continues working for sustained depression relief. A fast-acting antidepressant would be a welcome development for patients who must wait weeks for current drugs to take effect.

For someone with depression in the midst of a crisis, there is no time to waste. Yet time is exactly what currently-available antidepressants require to take effect -- often on the order of weeks.

Related Articles


A new study suggests a fast-acting antidepressant may be on the horizon. In mice, the drug produces evidence of a mood lift within 24 hours and then continues working for sustained relief.

"What makes this study unique and exciting is that in the same drug we seem to have both of the properties you want in an antidepressant -- both rapid and sustained effects," said Jeffery Talbot, Ph.D., director of the Research Center on Substance Abuse and Depression at Roseman University of Health Sciences and one of the study's lead investigators.

Though many drugs are currently available to treat people with depression, existing drugs do not work quickly, and they do not work for everyone. "Many people with depression simply don't respond to available medications," said Talbot. "There's still a real need for new antidepressants."

The drug, referred to by Talbot as its coded name MI-4 and better known among scientists as Ro-25-6981, has been shown by previous researchers to cause a rapid antidepressant effect in animals by blocking one of the brain's signaling chemicals. But until now, researchers were not aware of the full spectrum of its antidepressant properties.

The new study bolsters the evidence for MI-4's rapid effect and adds an exciting twist: MI-4 also works in the long term. Moreover, it may accomplish its long-term effects through a three-pronged approach known as triple reuptake inhibition, which refers to a drug's ability to simultaneously increase the levels of three key chemicals in the brain that are known to affect mood and feelings of pleasure -- dopamine, norepinephrine and serotonin. Most depression drugs only target one of these chemicals, which may explain why they are not effective in all patients.

The researchers found MI-4 via "virtual screening," a method that uses computer modeling to find drugs that are likely to interact with particular receptors in the brain. "From looking at its structure, one would never have guessed that this drug interacts with the same monoamine transporter proteins as does Paxil or cocaine, but it does. That speaks to the 'needle in a haystack' detection power of the virtual screening methodology," said Christopher Surratt, Ph.D., a professor of pharmacology working on this aspect of the study at Duquesne University.

Following the virtual screening, the researchers tested MI-4's effects in cell cultures and then in mice. In addition to providing new evidence of its antidepressant properties, the study shows MI-4 would be unlikely to become addictive.

Depression is one of the most common mental illnesses in the world, affecting about 20 million people in the United States. Causing persistent sadness and loss of energy, it can take an enormous toll on a person's ability to work or have healthy personal relationships and is a leading cause of suicide.

Antidepressants are some of the most commonly prescribed medications, with 264 million prescriptions written for antidepressants in 2011 totaling more than $11 billion in sales.

Jeffery Talbot will present the findings during the Experimental Biology 2014 meeting on Wednesday, April 30.

The study was funded by grants from the National Institute on Drug Abuse, the U.S. Department of Education and the Bower, Bennett & Bennett Research Endowment.


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology (FASEB). Note: Materials may be edited for content and length.


Cite This Page:

Federation of American Societies for Experimental Biology (FASEB). "Fast-acting antidepressant appears within reach." ScienceDaily. ScienceDaily, 30 April 2014. <www.sciencedaily.com/releases/2014/04/140430161301.htm>.
Federation of American Societies for Experimental Biology (FASEB). (2014, April 30). Fast-acting antidepressant appears within reach. ScienceDaily. Retrieved January 29, 2015 from www.sciencedaily.com/releases/2014/04/140430161301.htm
Federation of American Societies for Experimental Biology (FASEB). "Fast-acting antidepressant appears within reach." ScienceDaily. www.sciencedaily.com/releases/2014/04/140430161301.htm (accessed January 29, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, January 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Malnutrition on the Rise as Violence Flares in C. Africa

Malnutrition on the Rise as Violence Flares in C. Africa

AFP (Jan. 28, 2015) Violence can flare up at any moment in Bambari with only a bridge separating Muslims and Christians. Malnutrition is on the rise and lack of water means simple cooking fires threaten to destroy makeshift camps where people are living. Duration: 00:40 Video provided by AFP
Powered by NewsLook.com
Poultry Culled in Taiwan to Thwart Bird Flu

Poultry Culled in Taiwan to Thwart Bird Flu

Reuters - News Video Online (Jan. 28, 2015) Taiwan culls over a million poultry in efforts to halt various strains of avian flu. Julie Noce reports. Video provided by Reuters
Powered by NewsLook.com
Media Criticizing Parents For Not Vaccinating Children

Media Criticizing Parents For Not Vaccinating Children

Newsy (Jan. 28, 2015) As the Disneyland measles outbreak continues to spread, the media says parents who choose not to vaccinate their children are part of the cause. Video provided by Newsy
Powered by NewsLook.com
Shark Bite Victim Making Amazing Recovery

Shark Bite Victim Making Amazing Recovery

AP (Jan. 27, 2015) A Texas woman who lost more than five pounds of flesh to a shark in the Bahamas earlier this month could be released from a Florida hospital soon. Experts believe she was bitten by a bull shark while snorkeling. (Jan. 27) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins