Featured Research

from universities, journals, and other organizations

Conducting polymer films decorated with biomolecules for cell research use

Date:
May 9, 2014
Source:
Penn State
Summary:
The ability to create conducting polymer films in a variety of shapes, thicknesses and surface properties rapidly and inexpensively will make growing and testing cells easier and more flexible, according to a team of bioengineers. The researchers create their hydrogel stamps from agarose -- a sugar extracted from seaweed -- poured into molds.

This is an image of stamp and substrate.
Credit: Sheereen Majd, Penn State

The ability to create conducting polymer films in a variety of shapes, thicknesses and surface properties rapidly and inexpensively will make growing and testing cells easier and more flexible, according to a team of Penn State bioengineers.

Related Articles


"The ultimate goal of this collaborative project is to be able to create a substrate for growth and manipulation of cells," said Sheereen Majd, assistant professor of bioengineering. "Cells on a surface need to recognize biomolecules like extracellular matrix proteins to be able to adhere and grow. We ultimately would like to be able to use these polymer films to manipulate adhesion, growth, proliferation and migration of cells." Majd and her team are creating patterned films of conducting polymers on gold substrates by electrodeposition through hydrogel stamps. They report their results today (May 9) in Advanced Materials.

The researchers create their hydrogel stamps from agarose -- a sugar extracted from seaweed -- poured into molds. While most of the current experiments use arrays of dots, because the researchers use molded stamps, a wide variety of shapes -- dots, squares, lines -- are possible. The stamp is dipped in a solution of monomer and a dopant and placed on the gold surface. An electrical current through the hydrogel and gold polymerizes the monomer and dopant at the surface. If a biomolecule of interest is also included in the stamping solution, it becomes embedded in the polymer film as well.

Because the presence of dopant is important for the electrical conductivity of these polymers, only areas where monomer and dopant exist together form conductive films of polymer. The process takes from one to two minutes and the longer the current is applied, the thicker the film.

The researchers were able to produce a series of films using the same monomer but different dopants and biomolecules by altering the solution on various parts of the stamp. In this way researchers can change the surface properties and functionality of the films. The stamp can also be used multiple times before re-inking becomes necessary, simplifying and speeding up the process.

Creating arrays of different biomolecules and different shapes in conducting polymers is especially important when studying excitable cells like neurons or muscle cells because they react to electricity.

Conducting polymer arrays will allow manipulation of cells using chemical and electrical signals, expanding the ways cells can be treated. Varying films laid down on one substrate can put multiple experiments all in one


Story Source:

The above story is based on materials provided by Penn State. The original article was written by A'ndrea Elyse Messer. Note: Materials may be edited for content and length.


Journal Reference:

  1. SooHyun Park, Guang Yang, Nrutya Madduri, Mohammad Reza Abidian, Sheereen Majd. Direct Patterning: Hydrogel-Mediated Direct Patterning of Conducting Polymer Films with Multiple Surface Chemistries (Adv. Mater. 18/2014). Advanced Materials, 2014; 26 (18): 2964 DOI: 10.1002/adma.201470122

Cite This Page:

Penn State. "Conducting polymer films decorated with biomolecules for cell research use." ScienceDaily. ScienceDaily, 9 May 2014. <www.sciencedaily.com/releases/2014/05/140509140335.htm>.
Penn State. (2014, May 9). Conducting polymer films decorated with biomolecules for cell research use. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2014/05/140509140335.htm
Penn State. "Conducting polymer films decorated with biomolecules for cell research use." ScienceDaily. www.sciencedaily.com/releases/2014/05/140509140335.htm (accessed October 24, 2014).

Share This



More Plants & Animals News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Black Bear Cub Goes Sunday Shopping

Black Bear Cub Goes Sunday Shopping

Reuters - Light News Video Online (Oct. 23, 2014) Price check on honey? Bear cub startles Oregon drugstore shoppers. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Dances With Wolves in China's Wild West

Dances With Wolves in China's Wild West

AFP (Oct. 23, 2014) One man is on a mission to boost the population of wolves in China's violence-wracked far west. The animal - symbol of the Uighur minority there - is under threat with a massive human resettlement program in the region. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
Breakfast Debate: To Eat Or Not To Eat?

Breakfast Debate: To Eat Or Not To Eat?

Newsy (Oct. 23, 2014) Conflicting studies published in the same week re-ignited the debate over whether we should be eating breakfast. Video provided by Newsy
Powered by NewsLook.com
Weird-Looking Dinosaur Solves 50-Year-Old Mystery

Weird-Looking Dinosaur Solves 50-Year-Old Mystery

Newsy (Oct. 23, 2014) You've probably seen some weird-looking dinosaurs, but have you ever seen one this weird? It's worth a look. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins