Featured Research

from universities, journals, and other organizations

Risky decision making on brains of methamphetamine users examed with imaging

Date:
May 21, 2014
Source:
The JAMA Network Journals
Summary:
Methamphetamine users showed less sensitivity to risk and reward in one region of the brain and greater sensitivity in other brain regions compared with non-users when performing an exercise involving risky decision making. The authors used functional magnetic resonance imaging in a study of 25 methamphetamine users and 27 non-users (controls).

Methamphetamine users showed less sensitivity to risk and reward in one region of the brain and greater sensitivity in other brain regions compared with non-users when performing an exercise involving risky decision making.

Deficiencies in decision making are linked to addiction. Chronic methamphetamine use is associated with abnormalities in the neural circuits of the brain involved in risky decision making. Faulty decision making is targeted in addiction therapy so understanding its causes could help in the development of more effective treatments.

The authors used functional magnetic resonance imaging in a study of 25 methamphetamine users and 27 non-users (controls). The patients were examined at rest and when performing the Balloon Analogue Risk Task (BART), which involves the choice to pump up a balloon to increase earnings or cash out to avoid uncertain risk.

Methamphetamine users earned less than the healthy patients on the BART and they showed less sensitivity to risk and reward in the brain region known as the right dorsolateral prefrontal cortex (rDLPFC), greater sensitivity in the ventral striatum and greater mesocorticolimbic resting-state functional connectivity (RSFC). The healthy patients had a greater association between the RSFC of the rDLPFC and sensitivity of the rDLPFC to risk during risky decision making. The authors indicate that may suggest that a deficit in rDLPFC connectivity contributes to dysfunction in methamphetamine users.

"These findings suggest that circuit-level abnormalities affect brain function during risky decision making in stimulant users."


Story Source:

The above story is based on materials provided by The JAMA Network Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Milky Kohno, Angelica M. Morales, Dara G. Ghahremani, Gerhard Hellemann, Edythe D. London. Risky Decision Making, Prefrontal Cortex, and Mesocorticolimbic Functional Connectivity in Methamphetamine Dependence. JAMA Psychiatry, 2014; DOI: 10.1001/jamapsychiatry.2014.399

Cite This Page:

The JAMA Network Journals. "Risky decision making on brains of methamphetamine users examed with imaging." ScienceDaily. ScienceDaily, 21 May 2014. <www.sciencedaily.com/releases/2014/05/140521180024.htm>.
The JAMA Network Journals. (2014, May 21). Risky decision making on brains of methamphetamine users examed with imaging. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/2014/05/140521180024.htm
The JAMA Network Journals. "Risky decision making on brains of methamphetamine users examed with imaging." ScienceDaily. www.sciencedaily.com/releases/2014/05/140521180024.htm (accessed September 30, 2014).

Share This



More Health & Medicine News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How 'Yes Means Yes' Defines Sexual Assault

How 'Yes Means Yes' Defines Sexual Assault

Newsy (Sep. 29, 2014) Aimed at reducing sexual assaults on college campuses, California has adopted a new law changing the standard of consent for sexual activity. Video provided by Newsy
Powered by NewsLook.com
Scientists May Have Found An Early Sign Of Pancreatic Cancer

Scientists May Have Found An Early Sign Of Pancreatic Cancer

Newsy (Sep. 29, 2014) Researchers looked at 1,500 blood samples and determined people who developed pancreatic cancer had more branched chain amino acids. Video provided by Newsy
Powered by NewsLook.com
Colo. Doctors See Cluster of Enterovirus Cases

Colo. Doctors See Cluster of Enterovirus Cases

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com
Dr.'s Unsure of Cause of Fast-Spreading Virus

Dr.'s Unsure of Cause of Fast-Spreading Virus

AP (Sep. 29, 2014) Doctors at the Children's Hospital of Colorado say they have treated over 4,000 children with serious respiratory illnesses since August. Nine of the patients have shown distinct neurological symptoms, including limb weakness. (Sept. 29) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins