Featured Research

from universities, journals, and other organizations

Risky decision making on brains of methamphetamine users examed with imaging

Date:
May 21, 2014
Source:
The JAMA Network Journals
Summary:
Methamphetamine users showed less sensitivity to risk and reward in one region of the brain and greater sensitivity in other brain regions compared with non-users when performing an exercise involving risky decision making. The authors used functional magnetic resonance imaging in a study of 25 methamphetamine users and 27 non-users (controls).

Methamphetamine users showed less sensitivity to risk and reward in one region of the brain and greater sensitivity in other brain regions compared with non-users when performing an exercise involving risky decision making.

Deficiencies in decision making are linked to addiction. Chronic methamphetamine use is associated with abnormalities in the neural circuits of the brain involved in risky decision making. Faulty decision making is targeted in addiction therapy so understanding its causes could help in the development of more effective treatments.

The authors used functional magnetic resonance imaging in a study of 25 methamphetamine users and 27 non-users (controls). The patients were examined at rest and when performing the Balloon Analogue Risk Task (BART), which involves the choice to pump up a balloon to increase earnings or cash out to avoid uncertain risk.

Methamphetamine users earned less than the healthy patients on the BART and they showed less sensitivity to risk and reward in the brain region known as the right dorsolateral prefrontal cortex (rDLPFC), greater sensitivity in the ventral striatum and greater mesocorticolimbic resting-state functional connectivity (RSFC). The healthy patients had a greater association between the RSFC of the rDLPFC and sensitivity of the rDLPFC to risk during risky decision making. The authors indicate that may suggest that a deficit in rDLPFC connectivity contributes to dysfunction in methamphetamine users.

"These findings suggest that circuit-level abnormalities affect brain function during risky decision making in stimulant users."


Story Source:

The above story is based on materials provided by The JAMA Network Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Milky Kohno, Angelica M. Morales, Dara G. Ghahremani, Gerhard Hellemann, Edythe D. London. Risky Decision Making, Prefrontal Cortex, and Mesocorticolimbic Functional Connectivity in Methamphetamine Dependence. JAMA Psychiatry, 2014; DOI: 10.1001/jamapsychiatry.2014.399

Cite This Page:

The JAMA Network Journals. "Risky decision making on brains of methamphetamine users examed with imaging." ScienceDaily. ScienceDaily, 21 May 2014. <www.sciencedaily.com/releases/2014/05/140521180024.htm>.
The JAMA Network Journals. (2014, May 21). Risky decision making on brains of methamphetamine users examed with imaging. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2014/05/140521180024.htm
The JAMA Network Journals. "Risky decision making on brains of methamphetamine users examed with imaging." ScienceDaily. www.sciencedaily.com/releases/2014/05/140521180024.htm (accessed October 22, 2014).

Share This



More Health & Medicine News

Wednesday, October 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins