Featured Research

from universities, journals, and other organizations

On-off switch to burning stored fat found by scientists

Date:
June 5, 2014
Source:
University of Texas Health Science Center at San Antonio
Summary:
Scientists' discovery of how white fat cells are converted to beige, and the on-off switch for the process, could lead to novel diabetes and obesity drugs. "Understanding how beigeing is controlled is so very important because if we can improve energy expenditure, we can reduce obesity," the lead author said.

Scientists have reported that a molecular pathway called mTORC1 controls the conversion of unhealthy white fat into beige fat, an appealing target for increasing energy expenditure and reducing obesity. The team, led by researchers from the School of Medicine at The University of Texas Health Science Center at San Antonio, also found that a protein, Grb10, serves as the on-off switch for mTORC1 signaling and the "beigeing" of fat.

Related Articles


The finding could inform development of novel diabetes and obesity drugs, the scientists said. The study is reported in this month's issue of Cell Metabolism and was selected as the highlighted featured article.

Heat in response to cold

Grb10 is stimulated by cold stress, which causes the body to burn energy. ""We know that if we want to keep our body lean, we have to get rid of extra nutrients in the body, which means burning more energy," said senior author Feng Liu, Ph.D., professor of pharmacology at the UT Health Science Center and director of the Metabolic Syndrome Research Center at Xiangya Second Hospital, Central South University, in Changsha, China.

"Understanding how beigeing is controlled is so very important because if we can improve energy expenditure, we can reduce obesity," Dr. Liu said.

Undesirable storage

Adipose (fat) tissues, which include white adipose tissue and brown adipose tissue, are important regulators of metabolism. Having too much white adipose tissue and not burning it off through exercise or other energy expenditure is associated with obesity and metabolic diseases such as type 2 diabetes.

"Normally when we eat something, we store it in white fat," said co-author Lily Dong, Ph.D., professor of cellular and structural biology at the UT Health Science Center. "For the extra food we eat, it is better to release it, not store it. So finding a way to turn the white fat into beige and burn the energy that normally we store would have high therapeutic potential for the treatment of obesity and its related diseases. Dr. Liu has identified the pathway to do this."

Broader application

The mTORC1 pathway is also involved in aging, cardiovascular disease and cancer, so identifying the regulator of this pathway, Grb10, should be very informative for researching other fields, Dr. Liu said.

Drs. Liu and Dong also are members of the Health Science Center's Barshop Institute for Longevity and Aging Studies.


Story Source:

The above story is based on materials provided by University of Texas Health Science Center at San Antonio. Note: Materials may be edited for content and length.


Journal Reference:

  1. Meilian Liu, Juli Bai, Sijia He, Ricardo Villarreal, Derong Hu, Chuntao Zhang, Xin Yang, Huiyun Liang, ThomasJ. Slaga, Yonghao Yu, Zhiguang Zhou, John Blenis, PhilippE. Scherer, LilyQ. Dong, Feng Liu. Grb10 Promotes Lipolysis and Thermogenesis by Phosphorylation-Dependent Feedback Inhibition of mTORC1. Cell Metabolism, 2014; 19 (6): 967 DOI: 10.1016/j.cmet.2014.03.018

Cite This Page:

University of Texas Health Science Center at San Antonio. "On-off switch to burning stored fat found by scientists." ScienceDaily. ScienceDaily, 5 June 2014. <www.sciencedaily.com/releases/2014/06/140605141944.htm>.
University of Texas Health Science Center at San Antonio. (2014, June 5). On-off switch to burning stored fat found by scientists. ScienceDaily. Retrieved December 21, 2014 from www.sciencedaily.com/releases/2014/06/140605141944.htm
University of Texas Health Science Center at San Antonio. "On-off switch to burning stored fat found by scientists." ScienceDaily. www.sciencedaily.com/releases/2014/06/140605141944.htm (accessed December 21, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, December 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Existing Chemical Compounds Could Revive Failing Antibiotics, Says Danish Scientist

Reuters - Innovations Video Online (Dec. 21, 2014) A team of scientists led by Danish chemist Jorn Christensen says they have isolated two chemical compounds within an existing antipsychotic medication that could be used to help a range of failing antibiotics work against killer bacterial infections, such as Tuberculosis. Jim Drury went to meet him. Video provided by Reuters
Powered by NewsLook.com
Hugging It Out Could Help You Ward Off A Cold

Hugging It Out Could Help You Ward Off A Cold

Newsy (Dec. 21, 2014) Carnegie Mellon researchers found frequent hugs can help people avoid stress-related illnesses. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins