Featured Research

from universities, journals, and other organizations

Specific gene linked to adult growth of brain cells, learning, memory

Date:
June 9, 2014
Source:
City of Hope
Summary:
Stimulating a specific gene could prompt growth – in adults – of new neurons in this critical region, leading to faster learning and better memories, researchers report. Understanding the link between this gene and the growth of new neurons – or neurogenesis – is an important step in developing therapies to address impaired learning and memory associated with neurodegenerative diseases and aging.

Learning and memory are regulated by a region of the brain known as the hippocampus. New research from City of Hope has found that stimulating a specific gene could prompt growth – in adults – of new neurons in this critical region, leading to faster learning and better memories.

Related Articles


Understanding the link between this gene and the growth of new neurons – or neurogenesis – is an important step in developing therapies to address impaired learning and memory associated with neurodegenerative diseases and aging. The new research was published June 9 in the Proceedings of the National Academy of Sciences.

The study, which used an animal model, found that over-expressing the gene – a nuclear receptor called TLX – resulted in smart, faster learners that retained information better and longer.

“Memory loss is a major health problem, both in diseases like Alzheimer’s, but also just associated with aging,” said Yanhong Shi, Ph.D., lead author of the study and a neurosciences professor at City of Hope. “In our study, we manipulated the expression of this receptor by introducing an additional copy of the gene – which obviously we cannot do outside the laboratory setting. The next step is to find the drug that can target this same gene.”

The discovery creates a new potential strategy for improving cognitive performance in elderly patients and those who have a neurological disease or brain injury.

The bulk of the brain’s development happens before birth, and there are periods –largely in childhood and young adulthood – when the brain experiences bursts of new growth. In the past couple of decades, however, scientists have found evidence of neurogenesis in later adulthood – occurring mostly in the hippocampus, the region of the brain associated with learning and memory.

The new study is the first to firmly link the TLX gene to a potential for enhancing learning and memory.

Researchers found that over-expression of the gene was actually associated with a physically larger brain, as well as the ability to learn a task quickly. Furthermore, over-expression of the gene was linked with the ability to remember, over a longer period of time, what had been learned.


Story Source:

The above story is based on materials provided by City of Hope. Note: Materials may be edited for content and length.


Cite This Page:

City of Hope. "Specific gene linked to adult growth of brain cells, learning, memory." ScienceDaily. ScienceDaily, 9 June 2014. <www.sciencedaily.com/releases/2014/06/140609153329.htm>.
City of Hope. (2014, June 9). Specific gene linked to adult growth of brain cells, learning, memory. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2014/06/140609153329.htm
City of Hope. "Specific gene linked to adult growth of brain cells, learning, memory." ScienceDaily. www.sciencedaily.com/releases/2014/06/140609153329.htm (accessed November 27, 2014).

Share This


More From ScienceDaily



More Mind & Brain News

Thursday, November 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) — A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com
Winter Can Cause Depression — Here's How To Combat It

Winter Can Cause Depression — Here's How To Combat It

Newsy (Nov. 23, 2014) — Millions of American suffer from seasonal depression every year. It can lead to adverse health effects, but there are ways to ease symptoms. Video provided by Newsy
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) — Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Milestone Birthdays Can Bring Existential Crisis, Study Says

Milestone Birthdays Can Bring Existential Crisis, Study Says

Newsy (Nov. 21, 2014) — Researchers find that as people approach new decades in their lives they make bigger life decisions. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins