Featured Research

from universities, journals, and other organizations

Obesity gene linked to hormonal changes that favor energy surplus

Date:
June 11, 2014
Source:
Uppsala Universitet
Summary:
Elderly humans carrying a common variant of the fat mass and obesity gene FTO also have a shifted endocrine balance, research shows. Low blood concentrations of the satiety hormone leptin and high blood concentrations of the hunger promoting hormone ghrelin makes carriers of the FTO gene put on weight. “We found that elderly carrying an obesity-susceptible variant of the FTO gene had plasma ghrelin levels that were approximately 9 percent higher than in non-carriers,” says one researcher.

A new study from Uppsala University demonstrates that elderly humans carrying a common variant of the fat mass and obesity gene FTO also have a shifted endocrine balance. Low blood concentrations of the satiety hormone leptin and high blood concentrations of the hunger promoting hormone ghrelin makes carriers of the FTO gene put on weight. The findings are published in the journal Diabetes.

Related Articles


In the Prospective Investigation of the Vasculature in Uppsala Seniors, researchers from Uppsala University and the University of Umeε used data from 985 elderly participants (50% females) with an average age of 70 years to examine whether circulating levels of ghrelin and leptin, measured after an overnight fast, are linked to a common variant of FTO.

"We found that elderly carrying an obesity-susceptible variant of the FTO gene had plasma ghrelin levels that were approximately 9 percent higher than in non-carriers. In contrast, serum levels of the satiety enhancing hormone leptin were roughly 11 percent lower," says Christian Benedict, researcher at Uppsala University.

"The present findings suggest that this FTO variant may facilitate weight gain in humans by shifting the endocrine balance from the satiety hormone leptin toward the hunger promoting hormone ghrelin," says Christian Benedict.


Story Source:

The above story is based on materials provided by Uppsala Universitet. The original article was written by Linda Koffmar. Note: Materials may be edited for content and length.


Journal Reference:

  1. Benedict C et al. The fat mass and obesity-associated gene (FTO) is linked to higher plasma levels of the hunger hormone ghrelin and lower serum levels of the satiety hormone leptin in older adults - See more at: http://www.uu.se/en/media/press-release-document/?id=2334&am. Diabetes, June 2014 DOI: 10.2337/db14-0470 1939-327X

Cite This Page:

Uppsala Universitet. "Obesity gene linked to hormonal changes that favor energy surplus." ScienceDaily. ScienceDaily, 11 June 2014. <www.sciencedaily.com/releases/2014/06/140611112746.htm>.
Uppsala Universitet. (2014, June 11). Obesity gene linked to hormonal changes that favor energy surplus. ScienceDaily. Retrieved December 18, 2014 from www.sciencedaily.com/releases/2014/06/140611112746.htm
Uppsala Universitet. "Obesity gene linked to hormonal changes that favor energy surplus." ScienceDaily. www.sciencedaily.com/releases/2014/06/140611112746.htm (accessed December 18, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Thursday, December 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

UN: Up to One Million Facing Hunger in Ebola-Hit Countries

AFP (Dec. 17, 2014) — Border closures, quarantines and crop losses in West African nations battling the Ebola virus could lead to as many as one million people going hungry, UN food agencies said on Wednesday. Duration: 00:52 Video provided by AFP
Powered by NewsLook.com
When You Lose Weight, This Is Where The Fat Goes

When You Lose Weight, This Is Where The Fat Goes

Newsy (Dec. 17, 2014) — Can fat disappear into thin air? New research finds that during weight loss, over 80 percent of a person's fat molecules escape through the lungs. Video provided by Newsy
Powered by NewsLook.com
Why Your Boss Should Let You Sleep In

Why Your Boss Should Let You Sleep In

Newsy (Dec. 17, 2014) — According to research out of the University of Pennsylvania, waking up for work is the biggest factor that causes Americans to lose sleep. Video provided by Newsy
Powered by NewsLook.com
Flu Outbreak Closing Schools in Ohio

Flu Outbreak Closing Schools in Ohio

AP (Dec. 17, 2014) — A wave of flu illnesses has forced some Ohio schools to shut down over the past week. State officials confirmed one pediatric flu-related death, a 15-year-old girl in southern Ohio. (Dec. 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins