Featured Research

from universities, journals, and other organizations

Liver dangers from herbal supplements, OTC and RX drugs, new guidelines warn

Date:
June 17, 2014
Source:
American College of Gastroenterology (ACG)
Summary:
New clinical guidelines on the diagnosis and management of idiosyncratic drug-induced liver injury (DILI) have now been released. DILI is a rare adverse drug reaction, challenging to diagnose, and can lead to jaundice, liver failure and even death. The frequency of DILI incidence is increasing, as the use of herbal and dietary supplements has drastically increased over the last 10 years.

New clinical guidelines on the diagnosis and management of idiosyncratic drug-induced liver injury (DILI) appear in the July issue of The American Journal of Gastroenterology. DILI is a rare adverse drug reaction, challenging to diagnose, and can lead to jaundice, liver failure and even death. The frequency of DILI incidence is increasing, as the use of herbal and dietary supplements has drastically increased over the last 10 years.

Related Articles


The new guidelines from the American College of Gastroenterology, intended for use by physician and other health-care providers, include an overview of risk factors, diagnosis evaluation and causality assessment, prognosis factors, and management of hepatotoxicity due to pre-existing chronic liver disease or herbal/dietary supplement intake. One of the key focuses of the guidelines is on herbal and dietary supplements, which many doctors warn should be used with caution.

"A lot of consumers have a preconceived notion that if it's a natural product, it must be safe. But that is not necessarily the case," said Herbert Bonkovsky, MD, FACG, co-author of the guidelines. "Most of these products are not well-regulated and have very little oversight. Traces of heavy metals and prescription drugs have even been found in some herbal and dietary supplements. We encourage patients to talk to their doctor about all medications they are taking, and herbal and dietary supplements should be no exception."

The guidelines include a table of the most common over-the-counter and prescription drugs and supplements that cause DILI, and their usual patterns of liver injury. The table lists antibiotics (amoxicillin/clavulanate is the most commonly associated with DILI) and herbal and dietary supplements.

Of the herbal and dietary supplements, green tea extract tops the list as one of the most common dietary supplements associate with DILI injury. To give context, Dr. Bonkovsky says that the average cup of green tea has around 50-150 mgs of catechins, a group of polyphenols that are the major active ingredients. In some green tea extract pills, known to help with weight loss and other factors, the levels of such catechins can be over 700 mg. This can be particularly dangerous when the pills are taken multiple times a day.

It is important to note that DILI remains a "diagnosis of exclusion," which underscores the importance of patients giving their doctors a full history of all medications and supplement use. "Accurate history of medication exposure and onset and course of liver biochemistry abnormalities is crucial," says lead guideline author Naga P. Chalasani, MD, FACG.


Story Source:

The above story is based on materials provided by American College of Gastroenterology (ACG). Note: Materials may be edited for content and length.


Journal Reference:

  1. Naga P Chalasani, Paul H Hayashi, Herbert L Bonkovsky, Victor J Navarro, William M Lee, Robert J Fontana. ACG Clinical Guideline: The Diagnosis and Management of Idiosyncratic Drug-Induced Liver Injury. The American Journal of Gastroenterology, 2014; DOI: 10.1038/ajg.2014.131

Cite This Page:

American College of Gastroenterology (ACG). "Liver dangers from herbal supplements, OTC and RX drugs, new guidelines warn." ScienceDaily. ScienceDaily, 17 June 2014. <www.sciencedaily.com/releases/2014/06/140617091738.htm>.
American College of Gastroenterology (ACG). (2014, June 17). Liver dangers from herbal supplements, OTC and RX drugs, new guidelines warn. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/2014/06/140617091738.htm
American College of Gastroenterology (ACG). "Liver dangers from herbal supplements, OTC and RX drugs, new guidelines warn." ScienceDaily. www.sciencedaily.com/releases/2014/06/140617091738.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Christmas Kissing Good for Health

Christmas Kissing Good for Health

Reuters - Innovations Video Online (Dec. 22, 2014) Scientists in Amsterdam say couples transfer tens of millions of microbes when they kiss, encouraging healthy exposure to bacteria. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Brain-Dwelling Tapeworm Reveals Genetic Secrets

Brain-Dwelling Tapeworm Reveals Genetic Secrets

Reuters - Innovations Video Online (Dec. 22, 2014) Cambridge scientists have unravelled the genetic code of a rare tapeworm that lived inside a patient's brain for at least four year. Researchers hope it will present new opportunities to diagnose and treat this invasive parasite. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins