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Key to identifying, enriching mesenchymal stem cells found

Date:
June 20, 2014
Source:
UT Southwestern Medical Center
Summary:
A biomarker that enables researchers to accurately characterize the properties and function of mesenchymal stem cells (MSCs) in the body has been identified. MSCs are the focus of nearly 200 active clinical trials registered with the National Institutes of Health, targeting conditions such as bone fractures, cartilage injury, degenerative disc disease, and osteoarthritis.

Dr. Sean Morrison.
Credit: UT Southwestern

The Children's Medical Center Research Institute at UT Southwestern (CRI) has identified a biomarker that enables researchers to accurately characterize the properties and function of mesenchymal stem cells (MSCs) in the body. MSCs are the focus of nearly 200 active clinical trials registered with the National Institutes of Health, targeting conditions such as bone fractures, cartilage injury, degenerative disc disease, and osteoarthritis.

The finding, published in the journal Cell Stem Cell on June 19, significantly advances the field of MSC biology, and if the same biomarker identified in CRI's studies with mice works in humans, the outlook for clinical trials that use MSCs will be improved by the ability to better identify and characterize the relevant cells.

"There has been an increasing amount of clinical interest in MSCs, but advances have been slow because researchers to date have been unable to identify MSCs and study their normal physiological function in the body," said Dr. Sean Morrison, Director of the Children's Research Institute, Professor of Pediatrics at UT Southwestern Medical Center, and a Howard Hughes Medical Institute Investigator. "We found that a protein known as leptin receptor can serve as a biomarker to accurately identify MSCs in adult bone marrow in vivo, and that those MSCs are the primary source of new bone formation and bone repair after injury."

In the course of their investigation, the CRI researchers found that leptin receptor-positive MSCs are also the main source of factors that promote the maintenance of blood-forming stem cells in the bone marrow.

"Unfortunately, many clinical trials that are testing potential therapies using MSCs have been hampered by the use of poorly characterized and impure collections of cultured cells," said Dr. Morrison, senior author of the study and holder of the Mary McDermott Cook Chair in Pediatric Genetics at UT Southwestern. "If this finding is duplicated in our studies with human MSCs, then it will improve the characterization of MSCs that are used clinically and could increase the probability of success for well-designed clinical trials using MSCs."


Story Source:

The above story is based on materials provided by UT Southwestern Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Bo O. Zhou, Rui Yue, Malea M. Murphy, James G. Peyer, Sean J. Morrison. Leptin-Receptor-Expressing Mesenchymal Stromal Cells Represent the Main Source of Bone Formed by Adult Bone Marrow. Cell Stem Cell, 2014; DOI: 10.1016/j.stem.2014.06.008

Cite This Page:

UT Southwestern Medical Center. "Key to identifying, enriching mesenchymal stem cells found." ScienceDaily. ScienceDaily, 20 June 2014. <www.sciencedaily.com/releases/2014/06/140620143736.htm>.
UT Southwestern Medical Center. (2014, June 20). Key to identifying, enriching mesenchymal stem cells found. ScienceDaily. Retrieved August 21, 2014 from www.sciencedaily.com/releases/2014/06/140620143736.htm
UT Southwestern Medical Center. "Key to identifying, enriching mesenchymal stem cells found." ScienceDaily. www.sciencedaily.com/releases/2014/06/140620143736.htm (accessed August 21, 2014).

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