Featured Research

from universities, journals, and other organizations

Antiviral therapy can prevent liver cancer in chronic hepatitis B patients

Date:
June 23, 2014
Source:
American Gastroenterological Association
Summary:
One of the most severe complications of hepatitis B is the development of liver cancer, which is responsible for approximately 745,000 deaths worldwide each year. Two new studies provide strong evidence that antiviral therapy can reduce the risk of liver cancer in patients with chronic hepatitis B infection.

One of the most severe complications of hepatitis B is the development of liver cancer, which is responsible for approximately 745,000 deaths worldwide each year. Two new studies appearing in the June issue of Gastroenterology provide strong evidence that antiviral therapy can reduce the risk of liver cancer in patients with chronic hepatitis B infection. Gastroenterology is the official journal of the American Gastroenterological Association.

Related Articles


In the first paper,1 researchers from National Yang-Ming University in Taiwan showed that the licensed oral antiviral agent nucleos(t)ide (NUC) resulted in a reduced long-term risk for liver cancer in a large, nationwide cohort of chronic hepatitis B patients. This retrospective study analyzed the risk of hepatocellular carcinoma, the most common form of liver cancer, in patients treated with several different agents. The NUC-treated cohort had a significantly lower seven-year incidence of liver cancer compared with controls. Overall, the effect of the treatment on reduced risk for cancer was stronger in young patients without cirrhosis and in patients without diabetes.

"Our findings suggest that NUC use reduces the risk of liver cancer in chronic hepatitis B patients, particularly in younger patients with minimal liver damage," said lead study author Chun-Ying Wu, MD, PhD. "The large cohort contributed to the strength of our study, leading to reliable results regarding who can benefit the most from this treatment."

The second study,2 also a retrospective analysis, compared outcomes of chronic hepatitis B patients treated with the antiviral agent entecavir and a less potent drug, lamivudine, at a tertiary care hospital in Seoul, Korea. Researchers found that patients in the entecavir group had a significantly lower risk of death or transplantation than patients treated with lamivudine; however this reduction in risk did not translate to a decreased risk of liver cancer. Both groups produced a similar reduction in liver cancer.

"There is a persistent risk of liver cancer in hepatitis B patients treated with even the most potent agents," said study author Young-Suk Lim, MD, PhD, from department of gastroenterology, University of Ulsan College of Medicine, Seoul, Korea. "Based on our findings, we support recommendations that surveillance for liver cancer should be continued in chronic hepatitis B patients regardless of the treatment used."

Both papers support the accumulating evidence that, to avert the risk of liver cancer, antiviral therapy needs to be initiated early during the chronic hepatitis B infection, preferably before the stage of advanced fibrosis.


Story Source:

The above story is based on materials provided by American Gastroenterological Association. Note: Materials may be edited for content and length.


Journal References:

  1. Chun-Ying Wu, Jaw-Town Lin, Hsiu J. Ho, Chien-Wei Su, Teng-Yu Lee, Shen-Yung Wang, Chuhui Wu, Jaw-Ching Wu. Association of Nucleos(t)ide Analogue Therapy With Reduced Risk of Hepatocellular Carcinoma in Patients With Chronic Hepatitis B—A Nationwide Cohort Study. Gastroenterology, 2014; 147 (1): 143 DOI: 10.1053/j.gastro.2014.03.048
  2. Young–Suk Lim, Seungbong Han, Nae–Yun Heo, Ju Hyun Shim, Han Chu Lee, Dong Jin Suh. Mortality, Liver Transplantation, and Hepatocellular Carcinoma Among Patients With Chronic Hepatitis B Treated With Entecavir vs Lamivudine. Gastroenterology, 2014; 147 (1): 152 DOI: 10.1053/j.gastro.2014.02.033

Cite This Page:

American Gastroenterological Association. "Antiviral therapy can prevent liver cancer in chronic hepatitis B patients." ScienceDaily. ScienceDaily, 23 June 2014. <www.sciencedaily.com/releases/2014/06/140623155059.htm>.
American Gastroenterological Association. (2014, June 23). Antiviral therapy can prevent liver cancer in chronic hepatitis B patients. ScienceDaily. Retrieved January 31, 2015 from www.sciencedaily.com/releases/2014/06/140623155059.htm
American Gastroenterological Association. "Antiviral therapy can prevent liver cancer in chronic hepatitis B patients." ScienceDaily. www.sciencedaily.com/releases/2014/06/140623155059.htm (accessed January 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, January 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC: Get Vaccinated for Measles

CDC: Get Vaccinated for Measles

Reuters - US Online Video (Jan. 30, 2015) The CDC is urging people to get vaccinated for measles amid an outbreak that began at Disneyland and has now infected more than 90 people. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Obama To Outline New Plan For Personalized Medicine

Obama To Outline New Plan For Personalized Medicine

Newsy (Jan. 30, 2015) President Obama is expected to speak with drugmakers Friday about his Precision Medicine Initiative first introduced last week. Video provided by Newsy
Powered by NewsLook.com
NFL Concussions Down; Still on Parents' Minds

NFL Concussions Down; Still on Parents' Minds

AP (Jan. 30, 2015) The NFL announced this week that the number of game concussions dropped by a quarter over last season. Still, the dangers of the sport still weigh on players, and parents&apos; minds. (Jan. 30) Video provided by AP
Powered by NewsLook.com
U.S. Wants to Analyze DNA from 1 Million People

U.S. Wants to Analyze DNA from 1 Million People

Reuters - US Online Video (Jan. 30, 2015) The U.S. has proposed analyzing genetic information from more than 1 million American volunteers to learn how genetic variants affect health and disease. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins