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Is the next 'new' cancer drug already in your medicine cabinet? Antihistamines may have anti-cancer properties

Date:
June 30, 2014
Source:
Federation of American Societies for Experimental Biology
Summary:
The same types of drugs that help reduce watery eyes and runny noses during allergy season might also help ward off tumors too. A new research report suggests that antihistamines may have significant anti-cancer properties as they interfere with the function of a type of cell that is known to reduce the body's ability to fight tumors.

It turns out that the same types of drugs that help reduce watery eyes and runny noses during allergy season might also help ward off tumors too. A new research report appearing in the July 2014 issue of The Journal of Leukocyte Biology suggests that antihistamines may have significant anti-cancer properties as they interfere with the function of a type of cell that is known to reduce the body's ability to fight tumors (called "myeloid derived suppressor cells").

"This research is very exciting as it draws a connection between two diseases that aren't commonly linked: allergy and cancer," said Daniel H. Conrad, Ph.D., a researcher involved in the work from the Department of Microbiology and Immunology at Virginia Commonwealth University in Richmond, Virginia. "It's important to realize, however, that this connection is very novel and more research is needed before we know if antihistamines can be used effectively in cancer therapies."

To make this discovery, Conrad and colleagues examined two groups of mice that involve myeloid derived suppressor cells. The first group of mice was infected with a rodent intestinal helminth to simulate a strong allergic response. Then they were injected with myeloid derived suppressor cells and treated with anti-histamines, cetirizine or cimetidine. Treatment with these anti-histamines reversed the effects of myeloid derived suppressor cells. The second group of mice had tumors and were injected with myeloid derived suppressor cells and treated with the antihistamine, cimetidine. In this group, the antihistamine also reversed the enhanced tumor growth normally seen with myeloid derived suppressor cell injection. Finally, the scientists examined blood from patients with allergy symptoms (typically associated with increased histamine release). The scientists found that these patients had increased circulating myeloid derived suppressor cells over non-allergic controls.

"Antihistamines may be one of the most commonly used over-the-counter drugs, but this report shows that we still have much to learn about their potential benefits," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. "It is certainly not yet time to prophylactically administer antihistamines for cancer prevention, but the more we learn about myeloid derived suppressor cells, the more interesting these cells and their products become as immunotherapy targets in cancer. These new results suggest that we must be open-minded about seemingly distantly related immune mechanisms to examine."


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. R. K. Martin, S. J. Saleem, L. Folgosa, H. B. Zellner, S. R. Damle, G.-K. T. Nguyen, J. J. Ryan, H. D. Bear, A.-M. Irani, D. H. Conrad. Mast cell histamine promotes the immunoregulatory activity of myeloid-derived suppressor cells. Journal of Leukocyte Biology, 2014; 96 (1): 151 DOI: 10.1189/jlb.5A1213-644R

Cite This Page:

Federation of American Societies for Experimental Biology. "Is the next 'new' cancer drug already in your medicine cabinet? Antihistamines may have anti-cancer properties." ScienceDaily. ScienceDaily, 30 June 2014. <www.sciencedaily.com/releases/2014/06/140630114145.htm>.
Federation of American Societies for Experimental Biology. (2014, June 30). Is the next 'new' cancer drug already in your medicine cabinet? Antihistamines may have anti-cancer properties. ScienceDaily. Retrieved October 20, 2014 from www.sciencedaily.com/releases/2014/06/140630114145.htm
Federation of American Societies for Experimental Biology. "Is the next 'new' cancer drug already in your medicine cabinet? Antihistamines may have anti-cancer properties." ScienceDaily. www.sciencedaily.com/releases/2014/06/140630114145.htm (accessed October 20, 2014).

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