Featured Research

from universities, journals, and other organizations

'Molecular movies' will enable extraordinary gains in bioimaging, health research

Date:
June 30, 2014
Source:
Oregon State University
Summary:
An imaging technology more powerful than anything that has existed before, and is fast enough to observe life processes as they actually happen at the molecular level, has been created by scientists. This technology will allow creation of improved biosensors to study everything from nerve impulses to cancer metastasis as it occurs.

Fluorescent protein biosensors provide a technology to capture the biochemical process of life almost like a motion picture that could be viewed a frame at a time. This may allow the targeted design of next-generation biosensors to track life processes and battle diseases.
Credit: Graphic courtesy of Oregon State University

Researchers have announced the creation of an imaging technology more powerful than anything that has existed before, and is fast enough to observe life processes as they actually happen at the molecular level.

Related Articles


Chemical and biological actions can now be measured as they are occurring or, in old-fashioned movie parlance, one frame at a time. This will allow creation of improved biosensors to study everything from nerve impulses to cancer metastasis as it occurs.

The measurements, created by the use of short pulse lasers and bioluminescent proteins, are made in femtoseconds, which is one millionth of one billionth of a second. A femtosecond, compared to one second, is about the same as one second compared to 32 million years.

That's a pretty fast shutter speed, and it should change the way biological research and physical chemistry are being done, scientists say.

Findings on the new technology were published in Proceedings of the National Academy of Sciences, by researchers from Oregon State University and the University of Alberta.

"With this technology we're going to be able to slow down the observation of living processes and understand the exact sequences of biochemical reactions," said Chong Fang, an assistant professor of chemistry in the OSU College of Science, and lead author on the research.

"We believe this is the first time ever that you can really see chemistry in action inside a biosensor," he said. "This is a much more powerful tool to study, understand and tune biological processes."

The system uses advanced pulse laser technology that is, in itself, fairly new, and builds upon the use of "green fluorescent proteins" that are extremely popular in bioimaging and biomedicine. These remarkable proteins glow when light is shined upon them. Their discovery in 1962, and the applications that followed were the basis for a Nobel Prize in 2008.

Existing biosensor systems, however, are created largely by random chance or trial and error. By comparison, the speed of the new approach will allow scientists to "see" what is happening at the molecular level and create whatever kind of sensor they want by rational design. This will improve the study of everything from cell metabolism to nerve impulses, how a flu virus infects a person, or how a malignant tumor spreads.

"For decades, to create the sensors we have now, people have been largely shooting in the dark," Fang said. "This is a fundamental breakthrough in how to create biosensors for medical research from the bottom up. It's like daylight has finally come."

The technology, for instance, can follow the proton transfer associated with the movement of calcium ions -- one of the most basic aspects of almost all living systems, and also one of the fastest. This movement of protons is integral to everything from respiration to cell metabolism and even plant photosynthesis. Scientists will now be able to identify what is going on, one step at a time, and then use that knowledge to create customized biosensors for improved imaging of life processes.

"If you think of this in photographic terms," Fang said, "we now have a camera fast enough to capture the molecular dance of life. We're making molecular movies. And with this, we're going to be able to create sensors that answer some important, new questions in biophysics, biochemistry, materials science and biomedical problems."


Story Source:

The above story is based on materials provided by Oregon State University. Note: Materials may be edited for content and length.


Cite This Page:

Oregon State University. "'Molecular movies' will enable extraordinary gains in bioimaging, health research." ScienceDaily. ScienceDaily, 30 June 2014. <www.sciencedaily.com/releases/2014/06/140630164156.htm>.
Oregon State University. (2014, June 30). 'Molecular movies' will enable extraordinary gains in bioimaging, health research. ScienceDaily. Retrieved January 30, 2015 from www.sciencedaily.com/releases/2014/06/140630164156.htm
Oregon State University. "'Molecular movies' will enable extraordinary gains in bioimaging, health research." ScienceDaily. www.sciencedaily.com/releases/2014/06/140630164156.htm (accessed January 30, 2015).

Share This


More From ScienceDaily



More Matter & Energy News

Friday, January 30, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Tesla 'Insane Mode' Gives Unsuspecting Passengers the Ride of Their Life

Tesla 'Insane Mode' Gives Unsuspecting Passengers the Ride of Their Life

RightThisMinute (Jan. 29, 2015) — If your car has an "Insane Mode" then you know it&apos;s fast. Well, these unsuspecting passengers were in for one insane ride when they hit the button. Tesla cars are awesome. Video provided by RightThisMinute
Powered by NewsLook.com
Now Bill Gates Is 'Concerned' About Artificial Intelligence

Now Bill Gates Is 'Concerned' About Artificial Intelligence

Newsy (Jan. 29, 2015) — Bill Gates joins the list of tech moguls scared of super-intelligent machines. He says more people should be concerned, but why? Video provided by Newsy
Powered by NewsLook.com
Senate Passes Bill for Keystone XL Pipeline

Senate Passes Bill for Keystone XL Pipeline

AP (Jan. 29, 2015) — The Republican-controlled Senate has passed a bipartisan bill approving construction of the Keystone XL oil pipeline. (Jan. 29) Video provided by AP
Powered by NewsLook.com
Two Stunt Pilots Perform Incredibly Close Flyby

Two Stunt Pilots Perform Incredibly Close Flyby

Rumble (Jan. 29, 2015) — Two pilots from &apos;Escuadrilla Argentina de Acrobacia Aιrea&apos; perform an incredibly low altitude flyby stunt during a recent show exhibition in Argentina. Check it out! Video provided by Rumble
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Space & Time

Matter & Energy

Computers & Math

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins