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Two drugs for treating type 1 diabetes compared

Date:
July 3, 2014
Source:
Sanford Health
Summary:
Participants between the ages of 11 and 36 received either the two drugs or a placebo while continuing their insulin injections. The group receiving the drugs did not experience an improvement in insulin production, but some study participants whose GLP-1 and gastrin levels increased may have better preserved beta cell levels.

The results of The Sanford Project's first clinical trial are published in the July edition of The Lancet Diabetes & Endocrinology, revealing the outcome of a two-year study exploring the benefits of two drugs in treating type 1 diabetes.

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The study is titled "Combination therapy with sitagliptin and lansoprazole in patients with recent-onset type 1 diabetes (REPAIR-T1D): 12-month results of a multicentre, randomised, placebo-controlled, phase 2 trial."

In August 2012, The Sanford Project Todd and Linda Broin Chair Alex Rabinovitch, M.D., and his team announced they had reached full patient enrollment for Restore Pancreatic Insulin Response in type 1 diabetes (REPAIR-T1D). Based on a successful mouse model, the study explored if two FDA-approved drugs, sitagliptin and lansoprazole, could regenerate beta cells in humans by improving levels of GLP-1 and gastrin hormones. Type 1 diabetics experience a loss of insulin-producing beta cells and need to inject insulin into their bodies manually.

Sixty-nine participants between the ages of 11 and 36 received either the two drugs or a placebo while continuing their insulin injections. The group receiving the drugs did not experience an improvement in insulin production, but some study participants whose GLP-1 and gastrin levels increased may have better preserved beta cell levels.

"While the results of our first clinical trial did not indicate a regeneration of beta cells as a result of the drugs used, it is promising that some of the participants seemed to have preserved beta cells that may have otherwise died," said Rabinovitch. "The next step is to design another study based on what we learned from the REPAIR trial and continue to make progress towards a cure."

Rabinovitch is finalizing plans for the next clinical trial involving participants from the REPAIR-TID project to better understand why responses to the sitagliptin and lansoprazole differed among participants.

"What is perhaps most remarkable about the completion of this trial is the pace in which we are able to conduct research here at Sanford because of our size and strategic investments in people and infrastructure," said David Pearce, Ph.D., vice president and chief operating officer for Sanford Research. "The results have left The Sanford Project team both anxious and prepared to learn more about why patients reacted differently to the two drugs that were utilized in this clinical trial."

The REPAIR-T1D trial was funded by Sanford Research and JDRF.

"Curing T1D is challenging because of the complexity of the disease and the differences among the people who are diagnosed with it" said JDRF director and program lead Patricia Kilian, Ph.D. "The REPAIR-T1D study was an important translational effort; testing what was a promising approach in animals in a well-executed study with people. The results represent another step on the path towards improving beta cell function for people with T1D and our ultimate goal of finding a cure for the disease."


Story Source:

The above story is based on materials provided by Sanford Health. Note: Materials may be edited for content and length.


Journal Reference:

  1. Kurt J Griffin, Paul A Thompson, Michael Gottschalk, Jennifer H Kyllo, Alex Rabinovitch. Combination therapy with sitagliptin and lansoprazole in patients with recent-onset type 1 diabetes (REPAIR-T1D): 12-month results of a multicentre, randomised, placebo-controlled, phase 2 trial. The Lancet Diabetes & Endocrinology, 2014; DOI: 10.1016/S2213-8587(14)70115-9

Cite This Page:

Sanford Health. "Two drugs for treating type 1 diabetes compared." ScienceDaily. ScienceDaily, 3 July 2014. <www.sciencedaily.com/releases/2014/07/140703142158.htm>.
Sanford Health. (2014, July 3). Two drugs for treating type 1 diabetes compared. ScienceDaily. Retrieved November 23, 2014 from www.sciencedaily.com/releases/2014/07/140703142158.htm
Sanford Health. "Two drugs for treating type 1 diabetes compared." ScienceDaily. www.sciencedaily.com/releases/2014/07/140703142158.htm (accessed November 23, 2014).

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