Featured Research

from universities, journals, and other organizations

Novel protein complex with potential to combat gastric cancer caused by bacterial infection found by researchers

Date:
July 6, 2014
Source:
National University of Singapore
Summary:
A protein named IL23A is part of our stomach’s defense against bacterial infection which leads to gastric cancer, researchers have discovered. This finding could potentially be used to combat the deadly disease. Every year, some 740,000 people die from gastric cancer globally.

A team of scientists from the Cancer Science Institute of Singapore (CSI Singapore) at the National University of Singapore (NUS) discovered that a protein named IL23A is part of our stomach’s defence against bacterial infection which leads to gastric cancer. This finding could potentially be used to combat the deadly disease.

The research group, led by Professor Yoshiaki Ito, Senior Principal Investigator at CSI Singapore, also showed that the production of IL23A by stomach cells requires the tumour suppressor gene, RUNX3, which is frequently silenced in gastric cancer. The novel study was first published online in the leading journal Cell Reports on 4 July 2014.

Every year, some 740,000 people die from gastric cancer globally. In Singapore, stomach cancer was the fourth leading cause of cancer death among men and fifth among women from 2008 to 2012. This highlights the urgent need to understand the causes of this deadly disease. It is now known that a major trigger for the development of gastric cancer is the infection of a bacterium, Helicobacter pylori. A drawn-out battle against this bacterium often causes persistent inflammation of the stomach, which is a dangerous cancer-causing condition. As such, understanding and strengthening the natural defence mounted by our stomach cells is a logical and crucial step in preventing gastric cancer.

In this study, the researchers found that a protein named IL23A normally produced only by white blood cells is released by stomach cells when exposed to H. pylori. This demonstrates that IL23A is part of our stomach’s defence against bacterial infection. At the same time, they found that production of IL23A by stomach cells requires RUNX3, a tumour suppressor gene that is frequently silenced in gastric cancer. The involvement of RUNX3 appears particularly important during inflammation and infection caused by the bacterium. Their observation makes an important connection: when stomach cells lose RUNX3, they become defective in their ability to respond to infection by H. pylori, making the stomach vulnerable to this carcinogenic bacterium.

Prof Ito said, “We have been studying the frequent inactivation of RUNX3 in gastric cancer for some time. Our latest findings show that an important consequence of losing RUNX3 is a compromised immunity and this will enable us to devise better protection against pathogens.”

The study was supported by the Translational and Clinical Research Flagship Programme and the National Research Foundation of Singapore.

In the next phase of research, the team will focus on determining the function of the novel IL23A complex they discovered, as part of their overall strategy to combat H. pylori-induced gastric cancer. Concomitant application for patent protection of this work by NUS will facilitate industry involvement, so that this research can be effectively used to develop novel treatments to combat gastric cancer.


Story Source:

The above story is based on materials provided by National University of Singapore. Note: Materials may be edited for content and length.


Journal Reference:

  1. YitTeng Hor, DominicChih-Cheng Voon, JasonKinWai Koo, Huajing Wang, WenMin Lau, Hassan Ashktorab, ShingLeng Chan, Yoshiaki Ito. A Role for RUNX3 in Inflammation-Induced Expression of IL23A in Gastric Epithelial Cells. Cell Reports, 2014; DOI: 10.1016/j.celrep.2014.06.003

Cite This Page:

National University of Singapore. "Novel protein complex with potential to combat gastric cancer caused by bacterial infection found by researchers." ScienceDaily. ScienceDaily, 6 July 2014. <www.sciencedaily.com/releases/2014/07/140706153244.htm>.
National University of Singapore. (2014, July 6). Novel protein complex with potential to combat gastric cancer caused by bacterial infection found by researchers. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2014/07/140706153244.htm
National University of Singapore. "Novel protein complex with potential to combat gastric cancer caused by bacterial infection found by researchers." ScienceDaily. www.sciencedaily.com/releases/2014/07/140706153244.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Peace Corps Pulls Workers From W. Africa Over Ebola Fears

Newsy (July 30, 2014) The Peace Corps is one of several U.S.-based organizations to pull workers out of West Africa because of the Ebola outbreak. Video provided by Newsy
Powered by NewsLook.com
Weather Kills 2K A Year, But Storms Aren't The Main Offender

Weather Kills 2K A Year, But Storms Aren't The Main Offender

Newsy (July 30, 2014) Health officials say 2,000 deaths occur each year in the U.S. due to weather, but it's excessive heat and cold that claim the most lives. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins