Featured Research

from universities, journals, and other organizations

Chemotherapy resistance in inflammatory breast cancer due to newly identified mechanism

Date:
July 7, 2014
Source:
Roswell Park Cancer Institute
Summary:
A mechanism of breast cancer cells that leads to chemotherapy resistance in inflammatory breast cancer has been identified by researchers. Inflammatory breast cancer is the most aggressive type of advanced breast cancer and is characterized by rapid development, resistance to chemotherapy, early metastases and a poor prognosis. Inflammatory breast cancer cells display a triple-negative breast cancer phenotype that lacks the receptors needed to promote tumor growth. Therefore, common treatments are not effective for this breast cancer subtype.

Researchers at Roswell Park Cancer Institute (RPCI) have identified a mechanism of breast cancer cells that leads to chemotherapy resistance in inflammatory breast cancer. These preclinical findings, published online ahead of print in the International Journal of Oncology, provide evidence for a potential therapeutic approach that will restore sensitivity to chemotherapy and improve treatment of inflammatory breast cancer tumors.

Related Articles


"This study forms the basis for future research in patients with breast cancer and offers hope for targeted therapy for patients with aggressive triple-negative inflammatory breast cancer," said lead researcher Mateusz Opyrchal, M.D., Ph.D., Assistant Professor of Oncology at RPCI.

Inflammatory breast cancer is the most aggressive type of advanced breast cancer and is characterized by rapid development, resistance to chemotherapy, early metastases and a poor prognosis. Inflammatory breast cancer cells display a triple-negative breast cancer phenotype that lacks the receptors needed to promote tumor growth. Therefore, common treatments such as endocrine therapy and molecular targeting of the HER-2 receptor are not effective for this breast cancer subtype. No targeted therapy has been approved for noninflammatory and inflammatory triple-negative breast cancer tumors, and the standard of therapy for these tumors is a combination of conventional cytotoxic chemotherapeutic agents.

In the laboratory, Dr. Opyrchal and colleagues used breast cancer cell lines to determine the extent to which chromosomal instability and resistance to chemotherapy -- characteristics of inflammatory breast cancer -- are linked to the CD44+/CD24-/Low stem-like phenotype. They found that CD44+/CD24-/Low cancer stem cells (CSCs) were resistant to conventional chemotherapy but were sensitive to SU9516, which is a specific cyclin-dependent kinase 2 (Cdk2) inhibitor. The researchers concluded from these findings that aberrant activation of cyclin E/Cdk2 oncogenic signaling is essential for maintaining and expanding the CD44+/CD24-/Low subpopulation in inflammatory breast cancer. Therefore, a novel therapeutic approach in inflammatory breast cancer could involve a combination of conventional chemotherapy with small-molecule inhibitors of the Cdk2 cell cycle kinase.

"Cdk2 cell cycle kinase seems to play a role in the ability of cancer cells to be more aggressive and resistant to standard chemotherapy," Dr. Opyrchal said. "Blocking its function resulted in the improved ability of the chemotherapy drugs to kill cancer cells. Cancer stem cells will need to be identified and treated in a different manner than the bulk tumor."

Dr. Opyrchal noted that these results will have to be confirmed before human trials can be planned. His laboratory continues to work on identifying the cancer stem cells and signaling pathways that play a role in growth, metastatic potential and resistance to standard therapies.


Story Source:

The above story is based on materials provided by Roswell Park Cancer Institute. Note: Materials may be edited for content and length.


Journal Reference:

  1. Mateusz Opyrchal, Jeffrey Salisbury, Ianko Iankov, Mathew Goetz, James McCubrey, Mario Gambino, Lorenzo Malatino, Giuseppe Puccia, James Ingle, Evanthia Galanis, Antonino D'Assoro. Inhibition of Cdk2 kinase activity selectively targets the CD44 /CD24-/Low stem-like subpopulation and restores chemosensitivity of SUM149PT triple-negative breast cancer cells. International Journal of Oncology, 2014; DOI: 10.3892/ijo.2014.2523

Cite This Page:

Roswell Park Cancer Institute. "Chemotherapy resistance in inflammatory breast cancer due to newly identified mechanism." ScienceDaily. ScienceDaily, 7 July 2014. <www.sciencedaily.com/releases/2014/07/140707161542.htm>.
Roswell Park Cancer Institute. (2014, July 7). Chemotherapy resistance in inflammatory breast cancer due to newly identified mechanism. ScienceDaily. Retrieved March 29, 2015 from www.sciencedaily.com/releases/2014/07/140707161542.htm
Roswell Park Cancer Institute. "Chemotherapy resistance in inflammatory breast cancer due to newly identified mechanism." ScienceDaily. www.sciencedaily.com/releases/2014/07/140707161542.htm (accessed March 29, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, March 29, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com
These Popular Antibiotics Can Cause Permanent Nerve Damage

These Popular Antibiotics Can Cause Permanent Nerve Damage

Newsy (Mar. 27, 2015) A popular class of antibiotic can leave patients in severe pain and even result in permanent nerve damage. Video provided by Newsy
Powered by NewsLook.com
WH Plan to Fight Antibiotic-Resistant Germs

WH Plan to Fight Antibiotic-Resistant Germs

AP (Mar. 27, 2015) The White House on Friday announced a five-year plan to fight the threat posed by antibiotic-resistant bacteria amid fears that once-treatable germs could become deadly. (March 27) Video provided by AP
Powered by NewsLook.com
House Ready to Pass Medicare Doc Bill

House Ready to Pass Medicare Doc Bill

AP (Mar. 26, 2015) In rare bipartisan harmony, congressional leaders pushed a $214 billion bill permanently blocking physician Medicare cuts toward House passage Thursday, moving lawmakers closer to resolving a problem that has plagued them for years. (March 26) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins