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New medication shows promise in treating common skin disease

Date:
July 9, 2014
Source:
University of Rochester Medical Center
Summary:
An investigational medication shows promise in treating eczema or atopic dermatitis, the most common skin disorder, according to a study. The findings could eventually bring significant relief for many who suffer intense itching and other troubling features of atopic dermatitis, according to the study's lead author.
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An investigational medication shows promise in treating the most common skin disorder, often referred to as eczema or atopic dermatitis, according to a study published July 9 in the New England Journal of Medicine. The findings could eventually bring significant relief for many who suffer intense itching and other troubling features of atopic dermatitis, according to the study's lead author Lisa A. Beck, M.D., professor of Dermatology and Medicine at the University of Rochester Medical Center.

The drug, dupilumab, blocks the action of two proteins involved in inflammation, interleukin-4 and interleukin-13, which play a key role in atopic dermatitis (AD). AD is a common skin disease with troubling signs that include severely dry skin, red lesions that may crust or ooze, skin thickening, and symptoms of intense itching that may lead to skin wounds, infections and sleep disturbance.

Moderate-to-severe AD is a more chronic version of the disease that typically has more systemic features and is seen in up to 3 percent of adults with the disease. AD can impact a person's ability to lead a full and active life. In addition, people with AD are more likely to have asthma and other allergic disorders such as hay fever. Current treatments for AD include topical and oral steroids as well as phototherapy, but their effectiveness is limited or the side effects associated with their chronic use are significant.

"We are encouraged by the consistent findings across these studies, which show that patients treated with dupilumab had a marked improvement in disease activity and itch," Beck said. "At this point, dupilumab appears to be remarkably effective for adults with severe AD, although larger studies are needed to confirm its safety and efficacy."

Dupilumab is administered as a skin injection, and has shown promise in both Phase I and Phase II studies. Participants in a 12-week Phase II study showed a 74 percent reduction in the Eczema Area Severity Index, a tool used to measure the severity of a patient's condition, compared to only 23 percent in the placebo group. The majority of patients in the group receiving dupilumab experienced significant reductions in itch.

The study's findings set the stage for Phase III clinical trials of dupilumab, to confirm its effectiveness, monitor side effects, and compare it to commonly used treatments.


Story Source:

The above post is reprinted from materials provided by University of Rochester Medical Center. Note: Materials may be edited for content and length.


Journal Reference:

  1. Lisa A. Beck, Diamant Thaçi, Jennifer D. Hamilton, Neil M. Graham, Thomas Bieber, Ross Rocklin, Jeffrey E. Ming, Haobo Ren, Richard Kao, Eric Simpson, Marius Ardeleanu, Steven P. Weinstein, Gianluca Pirozzi, Emma Guttman-Yassky, Mayte Suárez-Fariñas, Melissa D. Hager, Neil Stahl, George D. Yancopoulos, Allen R. Radin. Dupilumab Treatment in Adults with Moderate-to-Severe Atopic Dermatitis. New England Journal of Medicine, 2014; 371 (2): 130 DOI: 10.1056/NEJMoa1314768

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University of Rochester Medical Center. "New medication shows promise in treating common skin disease." ScienceDaily. ScienceDaily, 9 July 2014. <www.sciencedaily.com/releases/2014/07/140709182238.htm>.
University of Rochester Medical Center. (2014, July 9). New medication shows promise in treating common skin disease. ScienceDaily. Retrieved September 1, 2015 from www.sciencedaily.com/releases/2014/07/140709182238.htm
University of Rochester Medical Center. "New medication shows promise in treating common skin disease." ScienceDaily. www.sciencedaily.com/releases/2014/07/140709182238.htm (accessed September 1, 2015).

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