Featured Research

from universities, journals, and other organizations

How cannabis compound could slow tumor growth

Date:
July 14, 2014
Source:
University of East Anglia
Summary:
Scientists have shown how the main psychoactive ingredient in cannabis, THC, could reduce tumor growth in cancer patients. New research reveals the existence of previously unknown signaling platforms which are responsible for the drug's success in shrinking tumors.

Scientists at the University of East Anglia have shown how the main psychoactive ingredient in cannabis could reduce tumor growth in cancer patients.
Credit: © Ondrej Hajek / Fotolia

Scientists at the University of East Anglia have shown how the main psychoactive ingredient in cannabis could reduce tumor growth in cancer patients.

Related Articles


Research published today reveals the existence of previously unknown signaling platforms which are responsible for the drug's success in shrinking tumours.

It is hoped that the findings could help develop a synthetic equivalent with anti-cancer properties.

The research was co-led with the Universidad Complutense de Madridin, Spain. The team used samples of human breast cancer cells to induce tumours in mice. They then targeted the tumours with doses of the cannabis compound THC (Tetrahydrocannabinol). They found that two cell receptors in particular were responsible for the drug's anti-tumour effects.

Dr Peter McCormick, from UEA's school of Pharmacy, said: "THC, the major active component of marijuana, has anti-cancer properties. This compound is known to act through a specific family of cell receptors called cannabinoid receptors. However, it was unclear which of these receptors were responsible for the anti-tumour effects of THC.

"We show that these effects are mediated via the joint interaction of CB2 and GPR55 -- two members of the cannabinoid receptor family. Our findings help explain some of the well-known but still poorly understood effects of THC at low and high doses on tumour growth.

"There has been a great deal of interest in understanding the molecular mechanisms behind how marijuana, and specifically THC, influence cancer pathology.

"There has also been a drive in the pharmaceutical industry to create synthetic equivalents that might have anti-cancer properties.

"By identifying the receptors involved we have provided an important step towards the future development of therapeutics that can take advantage of the interactions we have discovered to reduce tumour growth."

Dr McCormick added that cancer sufferers should not be tempted to self-medicate.

"Our research uses an isolated chemical compound and using the correct concentration is vital. Cancer patients should not use cannabis to self-medicate, but I hope that our research will lead to a safe synthetic equivalent being available in the future."


Story Source:

The above story is based on materials provided by University of East Anglia. Note: Materials may be edited for content and length.


Journal Reference:

  1. E. Moreno, C. Andradas, M. Medrano, M. M. Caffarel, E. Perez-Gomez, S. Blasco-Benito, M. Gomez-Canas, M. R. Pazos, A. J. Irving, C. Lluis, E. I. Canela, J. Fernandez-Ruiz, M. Guzman, P. J. McCormick, C. Sanchez. Targeting CB2-GPR55 Receptor Heteromers Modulates Cancer Cell Signaling. Journal of Biological Chemistry, 2014; DOI: 10.1074/jbc.M114.561761

Cite This Page:

University of East Anglia. "How cannabis compound could slow tumor growth." ScienceDaily. ScienceDaily, 14 July 2014. <www.sciencedaily.com/releases/2014/07/140714100339.htm>.
University of East Anglia. (2014, July 14). How cannabis compound could slow tumor growth. ScienceDaily. Retrieved November 28, 2014 from www.sciencedaily.com/releases/2014/07/140714100339.htm
University of East Anglia. "How cannabis compound could slow tumor growth." ScienceDaily. www.sciencedaily.com/releases/2014/07/140714100339.htm (accessed November 28, 2014).

Share This


More From ScienceDaily



More Mind & Brain News

Friday, November 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Tryptophan Isn't Making You Sleepy On Thanksgiving

Tryptophan Isn't Making You Sleepy On Thanksgiving

Newsy (Nov. 27, 2014) — Tryptophan, a chemical found naturally in turkey meat, gets blamed for sleepiness after Thanksgiving meals. But science points to other culprits. Video provided by Newsy
Powered by NewsLook.com
Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) — A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com
Winter Can Cause Depression — Here's How To Combat It

Winter Can Cause Depression — Here's How To Combat It

Newsy (Nov. 23, 2014) — Millions of American suffer from seasonal depression every year. It can lead to adverse health effects, but there are ways to ease symptoms. Video provided by Newsy
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) — Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins