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Genetic test helps predict which children with kidney disease will respond to standard therapy

Date:
July 24, 2014
Source:
American Society of Nephrology (ASN)
Summary:
Among children with sporadic nephrotic syndrome, genetic mutations in the kidney’s filtration barrier were frequently linked with a lack of response to immunosuppressive treatments, researchers report. The genetic test was even more predictive than a kidney biopsy for identifying children who would not benefit from immunosuppressive therapies.

A genetic screening test may help predict which patients with one of the most common childhood kidney diseases will respond to standard therapies. The test is described in a study appearing in an upcoming issue of the Journal of the American Society of Nephrology (JASN). Using this test could help guide clinicians as they counsel and treat patients.

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Sporadic nephrotic syndrome is one of the most common kidney diseases in children, and it can have a genetic cause. Paola Romagnani, MD, PhD, Sabrina Giglio, MD, PhD (University of Florence and Meyer Children's Hospital, in Florence, Italy), and their colleagues designed an innovative diagnostic approach that allows for a fast analysis of all genes involved in the disease. Using this method, the team analyzed 46 different genes at the same time in 69 children with the disease, and they found that genetic mutations in the kidney's filtration barrier were frequently linked with a lack of response to immunosuppressive treatments in patients. The genetic test was even more predictive than a kidney biopsy for identifying children who would not benefit from immunosuppressive therapies.

"Thus, this type of genetic analysis can improve the clinical approach to children with nephrotic syndrome by promoting better genetic counseling for the risk of recurrence of the disease in the family, and a better management of treatment and clinical follow up," said Professor Romagnani.

The application of this new diagnostic approach also improved the speed of clinical diagnoses of the disease and reduced costs. "With a single test, we can help build a truly personalized therapy," said Professor Giglio.


Story Source:

The above story is based on materials provided by American Society of Nephrology (ASN). Note: Materials may be edited for content and length.


Journal Reference:

  1. S. Giglio, A. Provenzano, B. Mazzinghi, F. Becherucci, L. Giunti, G. Sansavini, F. Ravaglia, R. M. Roperto, S. Farsetti, E. Benetti, M. Rotondi, L. Murer, E. Lazzeri, L. Lasagni, M. Materassi, P. Romagnani. Heterogeneous Genetic Alterations in Sporadic Nephrotic Syndrome Associate with Resistance to Immunosuppression. Journal of the American Society of Nephrology, 2014; DOI: 10.1681/ASN.2013111155

Cite This Page:

American Society of Nephrology (ASN). "Genetic test helps predict which children with kidney disease will respond to standard therapy." ScienceDaily. ScienceDaily, 24 July 2014. <www.sciencedaily.com/releases/2014/07/140724171753.htm>.
American Society of Nephrology (ASN). (2014, July 24). Genetic test helps predict which children with kidney disease will respond to standard therapy. ScienceDaily. Retrieved March 31, 2015 from www.sciencedaily.com/releases/2014/07/140724171753.htm
American Society of Nephrology (ASN). "Genetic test helps predict which children with kidney disease will respond to standard therapy." ScienceDaily. www.sciencedaily.com/releases/2014/07/140724171753.htm (accessed March 31, 2015).

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