Featured Research

from universities, journals, and other organizations

Making an IMPACT: Donation keeps innovative trials going

Date:
August 4, 2014
Source:
Rutgers Cancer Institute of New Jersey
Summary:
The method of treating cancer patients who have genomic abnormalities with drugs designed to target those abnormalities has resulted in higher response rates than previously seen. Often these discoveries are made as part of a clinical trial. Innovation of trial design and the need to streamline established processes for developing and executing these studies is more important than ever.

Research at Rutgers Cancer Institute of New Jersey.
Credit: Image courtesy of Rutgers Cancer Institute of New Jersey

The method of treating cancer patients who have genomic abnormalities with drugs designed specifically to target those abnormalities has resulted in higher response rates than have been previously seen. Often times these discoveries are made as part of a clinical trial. Patient participation in clinical research studies contributes to the advancement of scientific discovery and the development of the next generation of cancer treatments. Innovation of clinical trial design and the need to assess and streamline established processes for developing and executing these studies is more important than ever before. A $600,000 gift from Jewels of Charity is fueling a comprehensive clinical trial initiative at Rutgers Cancer Institute of New Jersey that will address those needs.

The effort is known as the Institutional Multidisciplinary Paradigm to Accelerate Collaboration and Translation (IMPACT). The aim -- as illustrated in the acronym -- is to enhance the way cancer discoveries are translated from the laboratory bench to patient bedside and back again. Further development of the IMPACT initiative will require increasing scientific depth to enable new approaches to improve the prevention, early detection, diagnosis and treatment of cancers.

Showing its commitment to clinical research and making a significant investment in this effort, the Cancer Institute earlier this year recruited a new Associate Director for Clinical Science. Howard L. Kaufman, MD, FACS, a leader in clinical and translational research, is nationally known for his work in cancer immunotherapy and melanoma. As part of the IMPACT initiative, Dr. Kaufman will lead six new specialized clinical trials aimed at molecular targets, as opposed to a specific tumor type, utilizing the strengths and capabilities of the Cancer Institute. The Jewels of Charity gift will enable $100,000 to be devoted to each of the six studies.

One of the six clinical trials will focus on a new approach that utilizes T cells (part of the white blood cells) from cancer patients in which the cells are genetically modified to attack only cancer cells. This approach requires specialized centers such as the Cancer Institute that have the capability of preparing these cells. These cells already have shown major clinical responses in patients with certain blood cancers, such as B cell lymphomas, chronic lymphocytic leukemias and in Hodgkin's lymphoma patients that have not responded to other treatments. It is expected that this approach will first be tested in patients with lymphoma and then in solid tumors, such as melanoma, ovarian cancer and lung cancer. The aim is to confirm the effectiveness and safety of these new agents and provide the best possible care for patients with difficult to treat cancers or those that have not responded to more established treatment options.


Story Source:

The above story is based on materials provided by Rutgers Cancer Institute of New Jersey. Note: Materials may be edited for content and length.


Cite This Page:

Rutgers Cancer Institute of New Jersey. "Making an IMPACT: Donation keeps innovative trials going." ScienceDaily. ScienceDaily, 4 August 2014. <www.sciencedaily.com/releases/2014/08/140804102938.htm>.
Rutgers Cancer Institute of New Jersey. (2014, August 4). Making an IMPACT: Donation keeps innovative trials going. ScienceDaily. Retrieved September 30, 2014 from www.sciencedaily.com/releases/2014/08/140804102938.htm
Rutgers Cancer Institute of New Jersey. "Making an IMPACT: Donation keeps innovative trials going." ScienceDaily. www.sciencedaily.com/releases/2014/08/140804102938.htm (accessed September 30, 2014).

Share This



More Health & Medicine News

Tuesday, September 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Newsy (Sep. 30, 2014) The CDC says a new case of Ebola has not been reported in Nigeria for more than 21 days, leading to hopes the outbreak might be nearing its end. Video provided by Newsy
Powered by NewsLook.com
UN Ebola Mission Head: Immediate Action Is Crucial

UN Ebola Mission Head: Immediate Action Is Crucial

AFP (Sep. 30, 2014) The newly appointed head of the United Nations Mission for Ebola Emergency Response (UNMEER), Anthony Banbury, outlines operations to tackle the virus. Duration: 00:39 Video provided by AFP
Powered by NewsLook.com
CDC Confirms First Case of Ebola in US

CDC Confirms First Case of Ebola in US

AP (Sep. 30, 2014) The CDC has confirmed the first diagnosed case of Ebola in the United States. The patient is being treated at a Dallas hospital after traveling earlier this month from Liberia. (Sept. 30) Video provided by AP
Powered by NewsLook.com
New Breast Cancer Drug Extends Lives In Clinical Trial

New Breast Cancer Drug Extends Lives In Clinical Trial

Newsy (Sep. 30, 2014) In a clinical trial, breast cancer patients lived an average of 15 months longer when they received new drug Perjeta along with Herceptin. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins