Featured Research

from universities, journals, and other organizations

New methods to identify MRSA in pigs

Date:
August 5, 2014
Source:
Technical University of Denmark (DTU)
Summary:
It is important to keep the number of MRSA infections at a low level. The latest technologies within whole genome sequencing have been exploited to develop new methods to identify genes which are important for the survival of MRSA in pigs.

It is important to keep the number of MRSA infections at a low level. In a PhD project at the National Food Institute, Technical University of Denmark, the latest technologies within whole genome sequencing were exploited to develop new methods to identify genes which are important for the survival of MRSA in pigs.

Traditionally, MRSA has been associated with severe infections which occur in hospitals and result in prolonged diseases and increased mortality. However, in recent years, MRSA has spread to the rest of the community, e.g. MRSA CC398 is found in pig production.

MRSA is resistant to the antibiotics with which we normally use for treatment of Staphylococcus infections.

In her PhD project at the National Food Institute, PhD student Mette Theilgaard exploited the latest technologies within whole genome sequencing and studied the entire DNA of MRSA CC398.

These studies have resulted in new methods, high-throughput approaches, which can identify genes important for the survival of MRSA in pigs. High-throughput approaches can identify those genes in the total gene pool of the bacteria which are essential, or the presence of which is advantageous, for the bacteria under some given circumstances.

Transfer of disease from animals to humans

The fact that MRSA can spread from animals to humans, where they may result in infections, has caused great concern in recent years. LA-MRSA ST398 is a new type and has turned out to be particularly successful in colonisation of pigs, from where it may transmit to humans.

Therefore, several monitoring studies focus on locating the origin of this MRSA type and its potential. Several central questions still remain unanswered, which makes it difficult to control the spread of this MRSA type. LA-MRSA ST398 is zoonotic, i.e. it can be transferred directly from animals to humans and cause disease. Thus, it is not sufficient to eradicate the bacteria from humans.

LA-MRSA ST398 has proven to be particularly successful in colonisation of pigs. By studying which genes are essential for the bacteria in pigs it may be possible for researchers to identify the factors important for the bacterium to colonise on pigs. We still don't know which specific genetic factors in this MRSA type facilitate the spread from animals to humans.

MRSA background

MRSA stands for methichillin-resistant Staphylococcus aureus.

When bacteria are exposed to antibiotics they protect themselves by developing resistance. They do this by changing their genes, either by mutating or by transferring resistance genes among themselves. It is, therefore, important not to overconsume antibiotics but only to use the necessary amount.

Staphylococci are bacteria which can be found in humans, animals and our surroundings. Staphylococcus aureus is part of the normal nasal and skin flora of approximately 50 % of the population. Staphylococcus aureus may cause various infections, ranging from superficial wounds and abscesses to severe infections such as bone inflammation and infection of the heart valve. In hospitals, Staphylococcus aureus is the most frequent cause of infections following surgery.


Story Source:

The above story is based on materials provided by Technical University of Denmark (DTU). Note: Materials may be edited for content and length.


Cite This Page:

Technical University of Denmark (DTU). "New methods to identify MRSA in pigs." ScienceDaily. ScienceDaily, 5 August 2014. <www.sciencedaily.com/releases/2014/08/140805090955.htm>.
Technical University of Denmark (DTU). (2014, August 5). New methods to identify MRSA in pigs. ScienceDaily. Retrieved September 22, 2014 from www.sciencedaily.com/releases/2014/08/140805090955.htm
Technical University of Denmark (DTU). "New methods to identify MRSA in pigs." ScienceDaily. www.sciencedaily.com/releases/2014/08/140805090955.htm (accessed September 22, 2014).

Share This



More Plants & Animals News

Monday, September 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Raw: San Diego Zoo Welcomes Cheetah Cubs

Raw: San Diego Zoo Welcomes Cheetah Cubs

AP (Sep. 20, 2014) The San Diego Zoo has welcomed two Cheetah cubs to its Safari Park. The nearly three-week-old female cubs are being hand fed and are receiving around the clock care. (Sept. 20) Video provided by AP
Powered by NewsLook.com
Chocolate Museum Opens in Brussels

Chocolate Museum Opens in Brussels

AFP (Sep. 19, 2014) Considered a "national heritage" in Belgium, chocolate now has a new museum in Brussels. In a former chocolate factory, visitors to the permanent exhibition spaces, workshops and tastings can discover derivatives of the cocoa bean. Duration: 01:00 Video provided by AFP
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins