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Smart bacteria help each other survive

Date:
August 5, 2014
Source:
Lund University
Summary:
The body’s assailants are cleverer than previously thought. New research shows for the first time how bacteria in the airways can help each other replenish vital iron. The bacteria thereby increase their chances of survival, which can happen at the expense of the person’s health.

The body's assailants are cleverer than previously thought. New research from Lund University in Sweden shows for the first time how bacteria in the airways can help each other replenish vital iron. The bacteria thereby increase their chances of survival, which can happen at the expense of the person's health.

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The bacteria Haemophilus influenzae is a type of bacteria in the respiratory tract that can cause ear infections and worsen the prognosis for COPD patients. In rare cases, it can also lead to meningitis and septicaemia.

"By accepting help from a specific protein, the Haemophilus bacteria can feed each other with iron and thus favour their survival in the human body. This interaction between the bacteria is a new discovery that has an impact on future research and on the development of vaccines and treatments," said Kristian Riesbeck, senior consultant and professor at the Department of Laboratory Medicine, Lund University.

All living organisms in the body need iron to survive. The iron can be captured via proteins that circulate in the blood. Earlier research from the same research group, as well as others, has shown that the surface layer of the bacteria is designed to enable the right type of proteins to attach.

"The iron in the body is strongly bound, but the bacteria try to get at it in various ways," explained Kristian Riesbeck.

In the case of Haemophilus influenzae, the bacteria can bind iron to a specific protein, protein E. Previously, it was only known that bacteria could assimilate the captured iron for their own use, but laboratory analyses have now shown that the bacteria can take advantage of one another in an ingenious way. The bacteria that were loaded with iron could transfer part of their load to other Haemophilus bacteria in their immediate vicinity that needed more.

"Protein E is a strong vaccine candidate for infections that often affect COPD patients and is now involved in a clinical trial. These findings reinforce the theory that the vaccine candidate is of major importance to Haemophilus, which suggests that a vaccine could work," said Tamim Al Jubair, a doctoral student in the research group.

The research group now plans to test whether other bacteria, in particular pneumococcal bacteria, could make use of Haemophilus protein E in a similar manner to access iron in conjunction with infections. Haemophilus and pneumococcal bacteria are the most common bacteria present in ear infections, sinusitis and pneumonia.


Story Source:

The above story is based on materials provided by Lund University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Tamim Al Jubair, Birendra Singh, Christophe Fleury, Anna M. Blom, Matthias Mφrgelin, Marjolein M. Thunnissen, Kristian Riesbeck. Haemophilus influenzae stores and distributes hemin by using Protein E. International Journal of Medical Microbiology, 2014; 304 (5-6): 662 DOI: 10.1016/j.ijmm.2014.04.015

Cite This Page:

Lund University. "Smart bacteria help each other survive." ScienceDaily. ScienceDaily, 5 August 2014. <www.sciencedaily.com/releases/2014/08/140805102551.htm>.
Lund University. (2014, August 5). Smart bacteria help each other survive. ScienceDaily. Retrieved November 22, 2014 from www.sciencedaily.com/releases/2014/08/140805102551.htm
Lund University. "Smart bacteria help each other survive." ScienceDaily. www.sciencedaily.com/releases/2014/08/140805102551.htm (accessed November 22, 2014).

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