Featured Research

from universities, journals, and other organizations

Monthly preventative treatment with a new drug combination reduces malaria in children

Date:
August 5, 2014
Source:
PLOS
Summary:
Preventative treatment with a monthly dose of a newer antimalarial drug can reduce the risk of malarial infection among young children, according to a new study. The study finds that treating young children with dihydroartemisinin-piperaquine decreased their risk of contracting malaria.

Preventative treatment with a monthly dose of a newer antimalarial drug can reduce the risk of malarial infection among young children, according to a study published in this week's PLOS Medicine. The study, conducted by Victor Bigira and colleagues at San Francisco General Hospital and the Makerere University College of Health Sciences in Kampala, Uganda, finds that treating young children with dihydroartemisinin-piperaquine (DP) decreased their risk of contracting malaria.

Related Articles


Preventative treatment of malaria is a useful strategy to protect young children in Africa, but it is unclear which drug and dosing strategy is most effective, especially with the rise of resistance to a class of drug known as antifolates, such as sulfadoxine-pyrimethamine (SP) and trimethoprim-sulfamethoxozole (TS). In this randomized controlled trial, the authors compared three treatment regimens, monthly SP, daily TS, monthly DP (a newer artemisinin-based combination therapy), and a no treatment control. The study enrolled 393 infants from Tororo, Uganda, and treated them from 6 to 24 months of age. The authors found that the incidence of malaria among the children treated with DP was lower than those with no treatment, 3.02 vs 6.95 episodes per person year (a protective efficacy of 58%). The protective efficacies of SP and TS were lower (7% and 28%) than DP.

There was no significant increase in adverse events with any of the treatments over the control group, nor was there any difference in malaria incidence between groups during the one year period after the study treatment was stopped, suggesting that monthly administration of DP is a safe and effective treatment for reducing malaria among infants in regions with year-round transmission and high resistance to antifolates.

The authors say: "The excellent efficacy of DP for the treatment of malaria in multiple countries and for chemoprevention in our high transmission area suggest that this regimen will offer benefit in many regions in need of improved control measures."

They continue: ." .. future studies are needed to evaluate the preventive efficacy of DP in other areas, maintain surveillance for potential selection of drug-resistant parasites, and evaluate the role of chemoprevention in the context of other available malaria control interventions such as the scale up of [insecticide treated nets] and use of indoor residual spraying of insecticides."


Story Source:

The above story is based on materials provided by PLOS. Note: Materials may be edited for content and length.


Journal Reference:

  1. Victor Bigira, James Kapisi, Tamara D. Clark, Stephen Kinara, Florence Mwangwa, Mary K. Muhindo, Beth Osterbauer, Francesca T. Aweeka, Liusheng Huang, Jane Achan, Diane V. Havlir, Philip J. Rosenthal, Moses R. Kamya, Grant Dorsey. Protective Efficacy and Safety of Three Antimalarial Regimens for the Prevention of Malaria in Young Ugandan Children: A Randomized Controlled Trial. PLoS Medicine, 2014; 11 (8): e1001689 DOI: 10.1371/journal.pmed.1001689

Cite This Page:

PLOS. "Monthly preventative treatment with a new drug combination reduces malaria in children." ScienceDaily. ScienceDaily, 5 August 2014. <www.sciencedaily.com/releases/2014/08/140805150825.htm>.
PLOS. (2014, August 5). Monthly preventative treatment with a new drug combination reduces malaria in children. ScienceDaily. Retrieved January 27, 2015 from www.sciencedaily.com/releases/2014/08/140805150825.htm
PLOS. "Monthly preventative treatment with a new drug combination reduces malaria in children." ScienceDaily. www.sciencedaily.com/releases/2014/08/140805150825.htm (accessed January 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, January 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Mistakes Should Serve a Lesson Says WHO

Ebola Mistakes Should Serve a Lesson Says WHO

AFP (Jan. 25, 2015) The World Health Organization&apos;s chief on Sunday admitted the UN agency had been caught napping on Ebola, saying it should serve a lesson to avoid similar mistakes in future. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Disneyland Measles Outbreak Spreads To 5 States

Disneyland Measles Outbreak Spreads To 5 States

Newsy (Jan. 24, 2015) Much of the Disneyland measles outbreak is being blamed on the anti-vaccination movement. The CDC encourages just about everyone get immunized. Video provided by Newsy
Powered by NewsLook.com
Growing Measles Outbreak Worries Calif. Parents

Growing Measles Outbreak Worries Calif. Parents

AP (Jan. 23, 2015) Public health officials are rushing to contain a measles outbreak that has sickened 70 people across 6 states and Mexico. The AP&apos;s Raquel Maria Dillon has more. (Jan. 23) Video provided by AP
Powered by NewsLook.com
Smart Wristband to Shock Away Bad Habits

Smart Wristband to Shock Away Bad Habits

Reuters - Innovations Video Online (Jan. 23, 2015) A Boston start-up is developing a wristband they say will help users break bad habits by jolting them with an electric shock. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins