Featured Research

from universities, journals, and other organizations

Gene likely to promote childhood cancers pinpointed by researchers

Date:
August 11, 2014
Source:
UT Southwestern Medical Center
Summary:
A gene that contributes to the development of several childhood cancers has been pinpointed by researchers in a study conducted with mice designed to model the cancers. The gene Lin28b is an attractive therapeutic target in cancer because it is ordinarily only expressed in embryos, so blocking it in children should specifically hinder cancer growth without introducing many side effects.

This is Dr. Hao Zhu.
Credit: UT Southwestern

Researchers at the Children's Medical Center Research Institute at UT Southwestern (CRI) have identified a gene that contributes to the development of several childhood cancers, in a study conducted with mice designed to model the cancers. If the findings prove to be applicable to humans, the research could lead to new strategies for targeting certain childhood cancers at a molecular level. The study was published today in the journal Cancer Cell.

"We and others have found that Lin28b -- a gene that is normally turned on in fetal but not adult tissues -- is expressed in several childhood cancers, including neuroblastoma, Wilms' tumor and hepatoblastoma, a type of cancer that accounts for nearly 80 percent of all liver tumors in children," said Dr. Hao Zhu, a principal investigator at CRI, and Assistant Professor of Pediatrics and Internal Medicine at UT Southwestern Medical Center. "In our study, we found that overproduction of Lin28b specifically causes hepatoblastoma, while blocking Lin28b impairs the cancer's growth. This opens up the possibility that pediatric liver cancer patients could one day be treated without resorting to chemotherapy."

Lin28b is an attractive therapeutic target in cancer because it is ordinarily only expressed in embryos, so blocking it in children should specifically hinder cancer growth without introducing many side effects.

Each year in the United States, 700 children are newly diagnosed with neuroblastoma, 500 with Wilms' tumor and 100 with hepatoblastoma. At Children's Medical Center in Dallas, more than 100 children have been treated for those three types of cancers over the last two years.

Previous studies found that Lin28b is a critical factor in stem cell and fetal tissue development, leading Dr. Zhu and his team to hypothesize that the same gene would play a significant role in the development of certain cancers.

"We looked at Lin28b in a multitude of ways in mice to study its effects on cancer, from increasing it significantly to deleting it," said Dr. Zhu, co-senior author of the paper. "From this and earlier studies, it appears that Lin28b activates the metabolic pathways that provide the building blocks of growth for certain cancers."

The next step for the Zhu lab is to establish whether genes related to Lin28b have similar effects on the development of cancer, and to determine if those genes might be more effective targets for potential therapies.


Story Source:

The above story is based on materials provided by UT Southwestern Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

UT Southwestern Medical Center. "Gene likely to promote childhood cancers pinpointed by researchers." ScienceDaily. ScienceDaily, 11 August 2014. <www.sciencedaily.com/releases/2014/08/140811125120.htm>.
UT Southwestern Medical Center. (2014, August 11). Gene likely to promote childhood cancers pinpointed by researchers. ScienceDaily. Retrieved September 20, 2014 from www.sciencedaily.com/releases/2014/08/140811125120.htm
UT Southwestern Medical Center. "Gene likely to promote childhood cancers pinpointed by researchers." ScienceDaily. www.sciencedaily.com/releases/2014/08/140811125120.htm (accessed September 20, 2014).

Share This



More Health & Medicine News

Saturday, September 20, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins