Featured Research

from universities, journals, and other organizations

Flexible sigmoidoscopy screening reduces colorectal cancer incidence, rate of death

Date:
August 12, 2014
Source:
JAMA - Journal of the American Medical Association
Summary:
Screening with flexible sigmoidoscopy resulted in a reduced incidence and rate of death of colorectal cancer, compared to no screening, according to a study of about 100,000 participants. Colorectal cancer is the third most commonly occurring cancer worldwide.

Among about 100,000 study participants, screening with flexible sigmoidoscopy resulted in a reduced incidence and rate of death of colorectal cancer, compared to no screening, according to a study in the August 13 issue of JAMA.

Colorectal cancer is the third most commonly occurring cancer worldwide. Most colorectal cancer cases develop from adenomas (benign tumors). Removal of adenomas by colonoscopy or flexible sigmoidoscopy (a thin flexible lighted tube used for inspection of the inside of the rectum and lower part of the colon) has been endorsed as a primary prevention tool for colorectal cancer, according to background information in the article.

Øyvind Holme, M.D., of the Sorlandet Hospital Kristiansand, Kristiansand, Norway and colleagues randomly assigned study participants in Norway to receive once-only flexible sigmoidoscopy (n=10, 283); a combination of once-only flexible sigmoidoscopy and fecal occult blood testing (FOBT; n=10,289), or no intervention (control group; n=78,220). Screening was performed in 1999-2000 (55-64-year age group) and in 2001 (50-54-year age group), with follow-up ending December 2011. Participants with positive screening test results were offered colonoscopy.

After a median of 11 years, 71 participants died of colorectal cancer in the screening groups vs 330 in the control group. Colorectal cancer was diagnosed in 253 participants in the screening groups vs 1,086 in the control group. Analysis of the data indicated that compared to no screening, flexible sigmoidoscopy screening reduced colorectal cancer incidence by 20 percent (absolute difference, 28.4 cases/100,000 person years) and colorectal cancer mortality by 27 percent (absolute difference, 11.7 deaths/100,000 person years). There was no significant difference in these outcomes between the flexible sigmoidoscopy only vs the flexible sigmoidoscopy and FOBT screening groups.

Younger participants 50 to 54 years of age seemed to benefit at least as much from the screening interventions as older participants ages 55 to 64 years.

Editorial: Flexible Sigmoidoscopy for Colorectal Cancer Screening: More Evidence, Persistent Ironies

In an accompanying editorial, Allan S. Brett, M.D., of the University of South Carolina School of Medicine, Columbia, S.C., writes that while there may be debate over the use of flexible sigmoidoscopy or colonoscopy for colorectal cancer screening, another screening technique, stool DNA testing, might render this debate moot in the not-too­distant future.

"A large, recently published study examined the performance of a multitarget stool test that identifies several DNA abnormalities associated with colorectal cancer or precancerous adenomas. With colonoscopy as the reference standard, the sensitivity of the stool DNA test was 92 percent for detecting cancer and 42 percent for detecting advanced precancerous lesions; specificity was 90 percent. Notably, the stool DNA test was much more sensitive than a separate fecal immunochemical test for hemoglobin performed for each participant. Repeated at some defined interval, stool DNA testing has potential to reduce colorectal cancer mortality substantially while sharply reducing the number of routine colonoscopies. For now, however, the muddled landscape of colorectal cancer screening in the United States continues, and the place of flexible sigmoidoscopy among screening tools remains unsettled."


Story Source:

The above story is based on materials provided by JAMA - Journal of the American Medical Association. Note: Materials may be edited for content and length.


Journal References:

  1. Øyvind Holme, Magnus Løberg, Mette Kalager, Michael Bretthauer, Miguel A. Hernán, Eline Aas, Tor J. Eide, Eva Skovlund, Jørn Schneede, Kjell Magne Tveit, Geir Hoff. Effect of Flexible Sigmoidoscopy Screening on Colorectal Cancer Incidence and Mortality. JAMA, 2014; 312 (6): 606 DOI: 10.1001/jama.2014.8266
  2. Allan S. Brett. Flexible Sigmoidoscopy for Colorectal Cancer Screening. JAMA, 2014; 312 (6): 601 DOI: 10.1001/jama.2014.8613

Cite This Page:

JAMA - Journal of the American Medical Association. "Flexible sigmoidoscopy screening reduces colorectal cancer incidence, rate of death." ScienceDaily. ScienceDaily, 12 August 2014. <www.sciencedaily.com/releases/2014/08/140812163310.htm>.
JAMA - Journal of the American Medical Association. (2014, August 12). Flexible sigmoidoscopy screening reduces colorectal cancer incidence, rate of death. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2014/08/140812163310.htm
JAMA - Journal of the American Medical Association. "Flexible sigmoidoscopy screening reduces colorectal cancer incidence, rate of death." ScienceDaily. www.sciencedaily.com/releases/2014/08/140812163310.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) — The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) — Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) — A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) — The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins