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White-matter deficits in users of codeine-containing cough syrups

Date:
August 20, 2014
Source:
American Society of Neuroradiology
Summary:
An imaging study of chronic users of codeine-containing cough syrups (CCS) has found deficits in specific regions of brain white matter and associates these changes with increased impulsivity in codeine-containing cough syrup users. These findings were consistent with results of previous studies of heroin and cocaine addicts. White matter disruptions also correlated with the duration of CCS use.

An imaging study of chronic users of codeine-containing cough syrups (CCS) has found deficits in specific regions of brain white matter and associates these changes with increased impulsivity in CCS users.

Researchers used diffusuion tensor imaging (DTI) (an MR imaging technique), coupled with fractional anisotropy, to investigate the white matter integrity of chronic CCS users. Deficits were found in multiple regions of the brain, including the inferior fronto-occipital fasciculus, which other studies have found to be abnormal in other forms of addiction, such as addiction to the Internet, alcohol and heroin.

The study found the white matter deficits in CCS users also correlated with increased impulsivity traits in the subjects, as measured by the Barratt Impulsiveness Scale. These findings were consistent with results of previous studies of heroin and cocaine addicts. White matter disruptions also correlated with the duration of CCS use.

Codeine-containing cough syrups have become one of the most popular drugs of abuse in young people around the world. Progressive changes in the white matter of users' brains may cause greater impulsivity in CCS users.

The study, titled "Abnormal White Matter Integrity in Chronic Users of Codeine-Containing Cough Syrups: A Tract-Based Spatial Statistics Study," was published this month on the website of the American Journal of Neuroradiology (AJNR).


Story Source:

The above story is based on materials provided by American Society of Neuroradiology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Y.- w. Qiu, H.- h. Su, X.- f. Lv, G.- h. Jiang. Abnormal White Matter Integrity in Chronic Users of Codeine-Containing Cough Syrups: A Tract-Based Spatial Statistics Study. American Journal of Neuroradiology, 2014; DOI: 10.3174/ajnr.A4070

Cite This Page:

American Society of Neuroradiology. "White-matter deficits in users of codeine-containing cough syrups." ScienceDaily. ScienceDaily, 20 August 2014. <www.sciencedaily.com/releases/2014/08/140820183944.htm>.
American Society of Neuroradiology. (2014, August 20). White-matter deficits in users of codeine-containing cough syrups. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2014/08/140820183944.htm
American Society of Neuroradiology. "White-matter deficits in users of codeine-containing cough syrups." ScienceDaily. www.sciencedaily.com/releases/2014/08/140820183944.htm (accessed October 21, 2014).

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