Featured Research

from universities, journals, and other organizations

APOB, a gene involved in lipid transport, linked to cases of familial extreme longevity

Date:
August 25, 2014
Source:
Centro Nacional de Investigaciones Oncologicas (CNIO)
Summary:
Scientists have identified rare variants in the APOB gene in several families where exceptional longevity (more than 100 years of age) appears to cluster.

In a recent report in Aging Cell, a multidisciplinary team of Spanish scientists, led by Tim Cash and Manuel Serrano at the Spanish National Cancer Research Centre (CNIO), identify rare variants in the APOB gene in several families where exceptional longevity (more than 100 years of age) appears to cluster.

Investigators identified three Spanish families with at least two siblings of around 100 years of age and they sequenced their genes in the hope of finding rare variants that could be associated with extreme longevity.

Remarkably, only one gene was found carrying rare variants in all the long-lived siblings of the three families, namely, APOB.

APOB is an attractive longevity gene because of its previous link to hypobetalipoproteinemia, a putative "longevity syndrome" and also because the protein encoded by APOB works in lipid transport together with the related protein APOE, which has common genetic variants with undisputed assocations with longevity.

This work is a first step in the identification of the genetic basis of familial extreme longevity and it points to cholesterol and lipid metabolism as an important determinant of human longevity.


Story Source:

The above story is based on materials provided by Centro Nacional de Investigaciones Oncologicas (CNIO). Note: Materials may be edited for content and length.


Journal Reference:

  1. Timothy P. Cash, Guillermo Pita, Orlando Domínguez, Maria R. Alonso, Leticia T. Moreno, Consuelo Borrás, Leocadio Rodríguez-Mañas, Catalina Santiago, Nuria Garatachea, Alejandro Lucia, Juan A. Avellana, Jose Viña, Anna González-Neira, Manuel Serrano. Exome sequencing of three cases of familial exceptional longevity. Aging Cell, 2014; DOI: 10.1111/acel.12261

Cite This Page:

Centro Nacional de Investigaciones Oncologicas (CNIO). "APOB, a gene involved in lipid transport, linked to cases of familial extreme longevity." ScienceDaily. ScienceDaily, 25 August 2014. <www.sciencedaily.com/releases/2014/08/140825100047.htm>.
Centro Nacional de Investigaciones Oncologicas (CNIO). (2014, August 25). APOB, a gene involved in lipid transport, linked to cases of familial extreme longevity. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2014/08/140825100047.htm
Centro Nacional de Investigaciones Oncologicas (CNIO). "APOB, a gene involved in lipid transport, linked to cases of familial extreme longevity." ScienceDaily. www.sciencedaily.com/releases/2014/08/140825100047.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How Nigeria Beat Its Ebola Outbreak

How Nigeria Beat Its Ebola Outbreak

Newsy (Oct. 20, 2014) — The World Health Organization has declared Nigeria free of Ebola. Health experts credit a bit of luck and the government's initial response. Video provided by Newsy
Powered by NewsLook.com
Another Study Suggests Viagra Is Good For The Heart

Another Study Suggests Viagra Is Good For The Heart

Newsy (Oct. 20, 2014) — An ingredient in erectile-dysfunction medications such as Viagra could improve heart function. Perhaps not surprising, given Viagra's history. Video provided by Newsy
Powered by NewsLook.com
Ebola Worries End for Dozens on U.S. Watch Lists

Ebola Worries End for Dozens on U.S. Watch Lists

Reuters - US Online Video (Oct. 20, 2014) — Forty-three people who had contact with Thomas Eric Duncan, the first person diagnosed with Ebola in the U.S., were cleared overnight of twice-daily monitoring after 21 days of showing no symptoms. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
CDC Calls for New Ebola Safety Guidelines

CDC Calls for New Ebola Safety Guidelines

AP (Oct. 20, 2014) — Centers for Disease Control and Prevention Director Dr. Tom Frieden laid out new guidelines for health care workers when dealing with the deadly Ebola virus including new precautions when taking off personal protective equipment. (Oct. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins