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APOB, a gene involved in lipid transport, linked to cases of familial extreme longevity

Date:
August 25, 2014
Source:
Centro Nacional de Investigaciones Oncologicas (CNIO)
Summary:
Scientists have identified rare variants in the APOB gene in several families where exceptional longevity (more than 100 years of age) appears to cluster.

In a recent report in Aging Cell, a multidisciplinary team of Spanish scientists, led by Tim Cash and Manuel Serrano at the Spanish National Cancer Research Centre (CNIO), identify rare variants in the APOB gene in several families where exceptional longevity (more than 100 years of age) appears to cluster.

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Investigators identified three Spanish families with at least two siblings of around 100 years of age and they sequenced their genes in the hope of finding rare variants that could be associated with extreme longevity.

Remarkably, only one gene was found carrying rare variants in all the long-lived siblings of the three families, namely, APOB.

APOB is an attractive longevity gene because of its previous link to hypobetalipoproteinemia, a putative "longevity syndrome" and also because the protein encoded by APOB works in lipid transport together with the related protein APOE, which has common genetic variants with undisputed assocations with longevity.

This work is a first step in the identification of the genetic basis of familial extreme longevity and it points to cholesterol and lipid metabolism as an important determinant of human longevity.


Story Source:

The above story is based on materials provided by Centro Nacional de Investigaciones Oncologicas (CNIO). Note: Materials may be edited for content and length.


Journal Reference:

  1. Timothy P. Cash, Guillermo Pita, Orlando Domínguez, Maria R. Alonso, Leticia T. Moreno, Consuelo Borrás, Leocadio Rodríguez-Mañas, Catalina Santiago, Nuria Garatachea, Alejandro Lucia, Juan A. Avellana, Jose Viña, Anna González-Neira, Manuel Serrano. Exome sequencing of three cases of familial exceptional longevity. Aging Cell, 2014; DOI: 10.1111/acel.12261

Cite This Page:

Centro Nacional de Investigaciones Oncologicas (CNIO). "APOB, a gene involved in lipid transport, linked to cases of familial extreme longevity." ScienceDaily. ScienceDaily, 25 August 2014. <www.sciencedaily.com/releases/2014/08/140825100047.htm>.
Centro Nacional de Investigaciones Oncologicas (CNIO). (2014, August 25). APOB, a gene involved in lipid transport, linked to cases of familial extreme longevity. ScienceDaily. Retrieved January 27, 2015 from www.sciencedaily.com/releases/2014/08/140825100047.htm
Centro Nacional de Investigaciones Oncologicas (CNIO). "APOB, a gene involved in lipid transport, linked to cases of familial extreme longevity." ScienceDaily. www.sciencedaily.com/releases/2014/08/140825100047.htm (accessed January 27, 2015).

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