Featured Research

from universities, journals, and other organizations

Research reveals mechanism behind cell protein remodeling

Date:
August 28, 2014
Source:
Rutgers Cancer Institute of New Jersey
Summary:
The remodeling of a kitchen or bathroom changes the appearance of the room and improves its functionality. As investigators have demonstrated, a similar concept comes into play in remodeling proteins found within a family of cancers that does not respond well to cancer-treating drugs -- cancers driven by what is known as activated Ras.

The remodeling of a kitchen or bathroom changes the appearance of the room and improves its functionality. As investigators at Rutgers Cancer Institute of New Jersey and Rutgers and Princeton Universities have demonstrated, a similar concept comes into play in remodeling proteins found within a family of cancers that does not respond well to cancer-treating drugs -- cancers driven by what is known as activated Ras.

Related Articles


According to the National Cancer Institute, more than a third of all human cancers are driven by mutations in the Ras family of genes. When Ras is activated, it promotes tumor growth but also activates autophagy which helps to sustain that growth. These cancers remodel proteins using the cellular self-cannibalization process known as autophagy to capture and degrade intracellular proteins and protein-containing organelles. Since Ras-driven cancers often rely on autophagy for growth and survival, this raised the question: Is proteome remodeling by autophagy important, and if so, by what mechanism?

This question was answered in research published in the current online edition of Molecular Cell, by senior author Eileen White, PhD, associate director for basic science at the Cancer Institute of New Jersey, and colleagues. They compared the global proteome (all of the expressed proteins) of Ras-driven cancer cells where autophagy was present to those where autophagy was deficient.

In this latest study researchers found that autophagy affects a majority of the proteins in Ras-driven cancers, yet the process is highly selective as to which proteins are targeted. For instance, investigators found that autophagy eliminates proteins involved in non-essential pathways or those deemed toxic under stressful conditions. Meanwhile, autophagy-resistant proteins involved in pathways needed for stress survival and autophagy maintenance were spared. The authors say these sets of proteins can serve as biomarkers for monitoring autophagy in the clinical setting. The study also revealed that defects in the autophagy process caused accumulation of certain proteins that prompted activation of an immune response in cancer cells and led to cell death.

"This remodeling process of the cell proteome by autophagy is an important immune-suppressive survival mechanism for Ras-driven cancers, and inhibiting autophagy can provide a means to target these aggressive cancers," notes White, who is also a distinguished professor of molecular biology and biochemistry at Rutgers School of Arts and Sciences.


Story Source:

The above story is based on materials provided by Rutgers Cancer Institute of New Jersey. Note: Materials may be edited for content and length.


Journal Reference:

  1. Robin Mathew, Sinan Khor, SeanR. Hackett, JoshuaD. Rabinowitz, DavidH. Perlman, Eileen White. Functional Role of Autophagy-Mediated Proteome Remodeling in Cell Survival Signaling and Innate Immunity. Molecular Cell, 2014; DOI: 10.1016/j.molcel.2014.07.019

Cite This Page:

Rutgers Cancer Institute of New Jersey. "Research reveals mechanism behind cell protein remodeling." ScienceDaily. ScienceDaily, 28 August 2014. <www.sciencedaily.com/releases/2014/08/140828135240.htm>.
Rutgers Cancer Institute of New Jersey. (2014, August 28). Research reveals mechanism behind cell protein remodeling. ScienceDaily. Retrieved April 19, 2015 from www.sciencedaily.com/releases/2014/08/140828135240.htm
Rutgers Cancer Institute of New Jersey. "Research reveals mechanism behind cell protein remodeling." ScienceDaily. www.sciencedaily.com/releases/2014/08/140828135240.htm (accessed April 19, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, April 19, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Our Love Of Puppy Dog Eyes Explained By Science

Our Love Of Puppy Dog Eyes Explained By Science

Newsy (Apr. 17, 2015) Researchers found a spike in oxytocin occurs in both humans and dogs when they gaze into each other&apos;s eyes. Video provided by Newsy
Powered by NewsLook.com
Dr. Oz Under Fire For 'Quack Treatments' Yet Again

Dr. Oz Under Fire For 'Quack Treatments' Yet Again

Newsy (Apr. 17, 2015) Ten doctors signed a letter urging Columbia University to drop Dr. Oz as vice chair of its department of surgery, saying he plugs "quack" treatments. Video provided by Newsy
Powered by NewsLook.com
Scientists Find Link Between Gestational Diabetes And Autism

Scientists Find Link Between Gestational Diabetes And Autism

Newsy (Apr. 17, 2015) Researchers who analyzed data from over 300,000 kids and their mothers say they&apos;ve found a link between gestational diabetes and autism. Video provided by Newsy
Powered by NewsLook.com
Video Messages Help Reassure Dementia Patients

Video Messages Help Reassure Dementia Patients

AP (Apr. 17, 2015) Family members are prerecording messages as part of a unique pilot program at the Hebrew Home in New York. The videos are trying to help victims of Alzheimer&apos;s disease and other forms of dementia break through the morning fog of forgetfulness. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins