Featured Research

from universities, journals, and other organizations

How studying damage to prefrontal lobe has helped unlock the brain's mysteries

Date:
August 28, 2014
Source:
Cell Press
Summary:
Until the last few decades, the frontal lobes of the brain were shrouded in mystery and erroneously thought of as nonessential for normal function. Now a review highlights groundbreaking studies of patients with brain damage that reveal how distinct areas of the frontal lobes are critical for a person's ability to learn, multitask, control emotions, socialize, and make decisions. The findings have helped experts rehabilitate patients experiencing damage to this brain region.

(A) This is an axial T2 magnetic resonance imaging (MRI) image showing an acute stroke in the left lateral prefrontal cortex. (B) This is a coronal neuropathological specimen of an infarct in the left lateral PFC (note the hemorrhagic conversion in the cortical mantle). The red dashed line on the MRI in (A) shows the approximate site of the postmortem coronal slice. (C) This is an axial T1 MRI image showing infiltrating glioblastoma in the right lateral frontal cortex. (D) This is a postmortem axial slice of an infiltrating glioblastoma in the right lateral frontal lobe. Neuropathological specimen in (B) compliments of Professor Dimitri Agamanolis, Akron Children's Hospital.
Credit: Neuron, Szczepanski et al.

Until the last few decades, the frontal lobes of the brain were shrouded in mystery and erroneously thought of as nonessential for normal function -- hence the frequent use of lobotomies in the early 20th century to treat psychiatric disorders. Now a review publishing August 28 in the Cell Press journal Neuron highlights groundbreaking studies of patients with brain damage that reveal how distinct areas of the frontal lobes are critical for a person's ability to learn, multitask, control their emotions, socialize, and make real-life decisions. The findings have helped experts rehabilitate patients experiencing damage to this region of the brain.

Although fairly common, damage to the prefrontal lobes (also called the prefrontal cortex) is often overlooked and undiagnosed because patients do not manifest obvious deficits. For example, patients with prefrontal brain damage do not lose any of their senses and often have preserved motor and language abilities, but they may manifest social abnormalities or difficulties with high-level planning in everyday life situations.

"In this review, we aimed to highlight a blend of new studies using cutting edge research techniques to investigate brain damage, but also to relate these new studies to original studies, some of which were published more than a century ago," said lead author Dr. Sara Szczepanski, of the University of California, Berkeley. "There is currently a large push to better understand the functions of the prefrontal cortex, and we believe that our review will make an important contribution to this understanding."

In addition to revealing the functions of different areas within the prefrontal cortex, studies have also demonstrated the flexibility of the region, which has helped experts optimize cognitive therapy techniques to enable patients with brain damage to learn new skills and compensate for their impairments.

The review indicates that by studying patients with damage to the prefrontal cortex, investigators can gain insights into this still-mysterious region of the brain that is critical for complex human skills and behavior.


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. SaraM. Szczepanski, RobertT. Knight. Insights into Human Behavior from Lesions to the Prefrontal Cortex. Neuron, 2014; DOI: 10.1016/j.neuron.2014.08.011

Cite This Page:

Cell Press. "How studying damage to prefrontal lobe has helped unlock the brain's mysteries." ScienceDaily. ScienceDaily, 28 August 2014. <www.sciencedaily.com/releases/2014/08/140828135517.htm>.
Cell Press. (2014, August 28). How studying damage to prefrontal lobe has helped unlock the brain's mysteries. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2014/08/140828135517.htm
Cell Press. "How studying damage to prefrontal lobe has helped unlock the brain's mysteries." ScienceDaily. www.sciencedaily.com/releases/2014/08/140828135517.htm (accessed September 16, 2014).

Share This



More Health & Medicine News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

President To Send 3,000 Military Personnel To Fight Ebola

President To Send 3,000 Military Personnel To Fight Ebola

Newsy (Sep. 16, 2014) President Obama is expected to send 3,000 troops to West Africa as part of the effort to contain Ebola's spread. Video provided by Newsy
Powered by NewsLook.com
Man Floats for 31 Hours in Gulf Waters

Man Floats for 31 Hours in Gulf Waters

AP (Sep. 16, 2014) A Texas man is lucky to be alive after he and three others floated for more than a day in the Gulf of Mexico when their boat sank during a fishing trip. (Sept. 16) Video provided by AP
Powered by NewsLook.com
EU Ministers and Experts Meet to Discuss Ebola Reponse

EU Ministers and Experts Meet to Discuss Ebola Reponse

AFP (Sep. 15, 2014) The European Commission met on Monday to coordinate aid that the EU can offer to African countries affected by the Ebola outbreak. Duration: 00:58 Video provided by AFP
Powered by NewsLook.com
Despite The Risks, Antibiotics Still Overprescribed For Kids

Despite The Risks, Antibiotics Still Overprescribed For Kids

Newsy (Sep. 15, 2014) A new study finds children are prescribed antibiotics twice as often as is necessary. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins