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Glaucoma drug, weight loss combo tested to restore vision

Date:
September 26, 2014
Source:
Saint Louis University Medical Center
Summary:
A blinding disorder, idiopathic intracranial hypertension (IIH), affects overweight young women. It is a condition, of unknown origin, causing raised intracranial pressure primarily in obese women. Those with IIH suffer debilitating headaches, and, because of pressure on the optic nerves, 86 percent develop some degree of vision loss. New research is aiming to bring relief to these patients.
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In an NIH-funded clinical trial, led at Saint Louis University by professor of ophthalmology Sophia Chung, M.D., researchers aim to bring sight back to those who have lost vision due to idiopathic intracranial hypertension (IIH).

IIH is a condition, of unknown origin, causing raised intracranial pressure primarily in obese women. Those with IIH suffer debilitating headaches, and, because of pressure on the optic nerves, 86 percent develop some degree of vision loss.

Around 100,000 Americans have IIH and the number is rising with the obesity epidemic. Of those with the disease, only 3 percent are men and most are women of childbearing age.

"IIH can be a debilitating condition, significantly diminishing quality of life," said Chung, who also is a SLUCare physician. "Because of vision loss, patients may have trouble with daily tasks, like driving and reading."

The NIH's National Eye Institute shared results from the first arm of the study earlier this year. Researchers were pleased to see that the combination of medication and weight loss not only preserved but also restored vision for many participants. Now, in the second stage of the trial, researchers will examine whether these benefits will last over time.

In the first part of the study, researchers tested whether a drug previously used for glaucoma and used for altitude sickness, acetazolamide, could improve mild vision loss when added to a weight loss program. Researchers at 38 sites enrolled 161 women and four men with IIH and mild vision loss and randomly assigned them to receive either the study drug or a placebo.

At the beginning of the study, the average BMI of participants was 40. All of those in the study were enrolled in weight loss plans aimed at losing six percent of their starting weight. Participants cut salt intake and 500 to 1000 calories a day, consulted with a weight loss coach, and were provided with simple exercise equipment.

The vision of patients receiving the drug improved by twice as much as those who received the placebo. Participants who both lost weight and took the medication had greater improvements in daily function and quality of life.

Now, in the second arm of the study, researchers will see if this drug and weight loss approach is a winning combination to manage symptoms over the long term. Researchers will follow participants for five years to see if their symptoms reappear and if they are able to maintain a healthy weight.

Chung currently is a director of the American Board of Ophthalmology. She has received multiple teaching honors for her work with residents and medical students at Saint Louis University.

Established in 1836, Saint Louis University School of Medicine has the distinction of awarding the first medical degree west of the Mississippi River. The school educates physicians and biomedical scientists, conducts medical research, and provides health care on a local, national and international level. Research at the school seeks new cures and treatments in five key areas: cancer, liver disease, heart/lung disease, aging and brain disease, and infectious disease.


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Materials provided by Saint Louis University Medical Center. Note: Content may be edited for style and length.


Cite This Page:

Saint Louis University Medical Center. "Glaucoma drug, weight loss combo tested to restore vision." ScienceDaily. ScienceDaily, 26 September 2014. <www.sciencedaily.com/releases/2014/09/140926112050.htm>.
Saint Louis University Medical Center. (2014, September 26). Glaucoma drug, weight loss combo tested to restore vision. ScienceDaily. Retrieved March 18, 2024 from www.sciencedaily.com/releases/2014/09/140926112050.htm
Saint Louis University Medical Center. "Glaucoma drug, weight loss combo tested to restore vision." ScienceDaily. www.sciencedaily.com/releases/2014/09/140926112050.htm (accessed March 18, 2024).

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