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Narcissistic personality disorder

Narcissistic personality disorder (NPD) is a form of pathological narcissism that first appeared as a disorder in the Diagnostic and Statistical Manual of Mental Disorders in 1980, in the edition known as DSM III-TR. As distinct from healthy narcissism, which all people possess to some extent, pathological narcissism is a maladaptive, rigid, and persistent condition that can cause significant distress and functional impairment.

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Mind & Brain News

October 14, 2025

Researchers have synthesized enhanced vitamin K analogues that outperform natural vitamin K in promoting neuron growth. The new compounds, which combine vitamin K with retinoic acid, activate the mGluR1 receptor to drive neurogenesis. They also ...
Researchers at USC have created the first method to noninvasively measure microscopic blood vessel pulses in the human brain. Using advanced 7T MRI, they found these tiny pulsations grow stronger with age and vascular risk, disrupting the brain’s ...
Groundbreaking Harvard research is exposing hidden energy failures inside brain cells that may drive major psychiatric conditions. By studying reprogrammed neurons, scientists are revealing how cellular metabolism shapes mood, thought, and ...
UMass Amherst engineers have built an artificial neuron powered by bacterial protein nanowires that functions like a real one, but at extremely low voltage. This allows for seamless communication with biological cells and drastically improved energy ...
Finasteride, a common hair-loss drug, has long been tied to depression and suicide, but regulators ignored the warnings. Prof. Mayer Brezis’s review exposes global data showing psychiatric harm and a pattern of inaction by Merck and the FDA. ...
People experiencing their first psychotic episode who also have skin conditions such as rashes or itching are at greater risk of depression and suicidal thoughts, according to new research presented at the ECNP meeting. Scientists found that 25% of ...
Different types of depression affect the body in different ways. Atypical, energy-related depression raises the risk of diabetes, while melancholic depression increases the likelihood of heart disease. Scientists say these differences reflect ...
Researchers have identified two compounds, K102 and K110, that could repair the nerve damage from multiple sclerosis. These drugs help regenerate the protective myelin sheath and balance immune ...
Scientists identified two types of brain cells, neurons and microglia, that are altered in people with depression. Through genomic mapping of post-mortem brain tissue, they found major differences in gene activity affecting mood and inflammation. ...
Scientists have pinpointed Y1 receptor neurons in the brain that can override chronic pain signals when survival instincts like hunger or fear take precedence. Acting like a neural switchboard, these cells balance pain with other biological needs. ...
Scientists at Skoltech developed a new mathematical model of memory that explores how information is encoded and stored. Their analysis suggests that memory works best in a seven-dimensional conceptual space — equivalent to having seven senses. ...
Researchers have designed a peptide that prevents the deadly misfolding of alpha-synuclein, the protein behind Parkinson’s and some dementias. In lab and animal tests, it stabilized the protein and ...

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