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MRI: An accurate method to evaluate iron overload

January 31, 2011
World Journal of Gastroenterology
A research team from Iran investigated the accuracy of T2*-weighted magnetic resonance imaging (MRI T2*) in the evaluation of iron overload in beta-thalassemia major patients. The study showed that MRI T2* is a non-invasive, safe and reliable method for detecting iron load in patients with iron overload.

Iron overload is a common and serious problem in thalassemic major patients. As iron accumulation is toxic in the body's tissues, accurate estimation of iron stores is of great importance in these patients to prevent iron overload by an appropriate iron chelating therapy.

Liver biopsy is the gold standard for evaluating iron stores but it is an invasive method which is not easily repeatable in patients. Introduction of other more applicable methods seems to be necessary.

A research article published on January 28, 2011 in the World Journal of Gastroenterology addresses this question. The authors reported their experience of using T2*-weighted magnetic resonance imaging (MRI T2*) for determining iron overload in beta-thalassemic patients in Iran. They compared liver MRI T2* results in thalassemic patients with their liver biopsy results to determine if it is possible to substitute MRI T2* to assess iron overload in these patients.

The results indicated that the serum ferritin level is not a reliable method for estimating the level of iron overload in thalassemic patients. MRI T2* is a more accurate and non-invasive method which they recommend for measurement of iron load in these patients.

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Materials provided by World Journal of Gastroenterology. Note: Content may be edited for style and length.

Journal Reference:

  1. Zamani F, Razmjou S, Akhlaghpoor S, Eslami SM, Azarkeivan A, Amiri A. T2* magnetic resonance imaging of the liver in thalassemic patients in Iran. World Journal of Gastroenterology, 2011; 17 (4): 522 DOI: 10.3748/wjg.v17.i4.522

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World Journal of Gastroenterology. "MRI: An accurate method to evaluate iron overload." ScienceDaily. ScienceDaily, 31 January 2011. <>.
World Journal of Gastroenterology. (2011, January 31). MRI: An accurate method to evaluate iron overload. ScienceDaily. Retrieved February 20, 2024 from
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