Skin Cancer News

October 2, 2023

Top Headlines

New Insights Into Melanoma Development and Therapy

Sep. 5, 2023 — Researchers have revealed that the expression of a specific isoform of GREB1 Is4 is induced in malignant melanoma cells by the melanocyte-specific transcription factor, MITF. They revealed that GREB1 Is4 stimulates pyrimidine biosynthesis and ...

Why Men, Wealthy People and Maritime Residents Are More Likely to Develop Skin Cancer

Aug. 31, 2023 — A new study examines why people living in Atlantic regions are more at-risk for developing melanoma than other Canadians, providing lessons on skin cancer prevention for the whole country. To find ...

A Medication Used for Heart Conditions Improves the Efficacy of Current Treatments for Melanoma in Mouse Models

Aug. 10, 2023 — The administration of ranolazine, a drug currently used to treat heart conditions, improves the efficacy of current therapies for melanoma, in mouse models of this ...

New RNA-Based Therapy Combats Melanoma in Mouse Models

July 27, 2023 — Investigators have designed an innovative RNA-based strategy to activate dendritic cells--which play a key role in immune response -- that eradicated tumors and prevented their recurrence in mouse models of melanoma. The findings suggest that the ...

Latest Headlines

updated 6:28pm EDT

Immobilizing Melanoma

July 26, 2023 — Although rare, mucosal melanoma in humans has a low survival rate. It has been difficult to investigate due to a lack of similar cancers in animals for study. Researchers explored a protein common to ...

A Two-for-One Approach to Boost Melanoma Immunotherapy

July 5, 2023 — New research has helped explain how melanoma evades the immune system and may guide the discovery of future therapies for the ...

Vaccine Delivers a Boost to T Cell Therapy

July 5, 2023 — A new vaccine boosts the response of engineered CAR-T cells and helps the immune system generate T cells that target other tumor antigens. The researchers found this approach made it more likely that ...

Researchers Uncover Immune Cell Marker and Regulator of Anti-Tumor Immunity

June 23, 2023 — B cells are thought to play a critical role in innate and adaptive immunity, but their exact role in anti-tumor immunity remains unknown. Researchers with expertise in immunology collaborated with ...

Gene Engineered Cell Therapy Developed to Target Brain Metastatic Melanomas

May 31, 2023 — Overall survival for patients with melanoma that has spread to the brain is only four to six months. Immunotherapies, which harness the power of the immune system to attack cancer cells, have ...

Candidate Found to Inhibit Malignant Melanoma Growth

Mar. 28, 2023 — Cancer-associated fibroblasts (CAFs) are key factors in the tumor microenvironment, which have been implicated in cancer cell progression. It has also been reported that vesicles called exosomes ...

Surprise Finding Shows That Neutrophils Can Be Key Antitumor Weapons

Mar. 30, 2023 — White blood cells called neutrophils have an unappreciated role in eradicating solid tumors, according to a surprise ...

Cancer Patients Who Don't Respond to Immunotherapy Lack Crucial Immune Cells

Feb. 16, 2023 — Cancer immunotherapy involves using activated T cells to destroy tumors, but it doesn't work for all patients. Researchers have discovered that a ...

Using a Seaweed Sugar to Trigger Immune Responses That Suppress Melanomas

Jan. 23, 2023 — Researchers have identified a relatively natural way to increase the numbers and antitumor activities of TILs. A team demonstrates how L-fucose, a nontoxic dietary plant sugar that is enriched in red ...

Researchers Identify Protein That Helps Skin Cancer Spread Throughout the Body

Jan. 9, 2023 — New research has identified a protein that makes melanoma, the most serious type of skin cancer, more aggressive by giving cancer cells the ability ...

Earlier Headlines

Summaries
Headlines

Researchers Uncover Potential Biomarkers of Positive Response to Immunotherapy

June 26, 2023 — Scientists have identified potential new biomarkers that could indicate how someone diagnosed with metastatic melanoma will respond to immunotherapy ...

Fewer Cases of Melanoma Among People Taking Vitamin D Supplements

Jan. 9, 2023 — Fewer cases of melanoma were observed among regular users of vitamin D supplements than among non-users, a new study finds. People taking vitamin D supplements regularly also had a considerably lower ...

Artificial DNA Kills Cancer

Dec. 21, 2022 — Researchers have used artificial DNA to target and kill cancer cells in a completely new way. The method was effective in lab tests against human cervical cancer- and breast cancer-derived cells, and ...

Drug Combination for Stage IV Melanoma Shows Success in Trial

Dec. 16, 2022 — A new study examined the combination of the common immunotherapy drug pembrolizumab (Keytruda) with all-trans retinoic acid (ATRA), a chemotherapy drug that targets myeloid-derived suppressor cells. ...

Patient's Own Immune Cells Effective as Living Medicine for Melanoma

Dec. 7, 2022 — A patient's own immune cells, multiplied into an army of billions of immune cells in a lab, can be used as a living medicine against metastatic melanoma, an aggressive form of skin cancer, as ...

Using Math to Better Treat Cancer

Nov. 28, 2022 — Researchers have identified a new method for scheduling radiation therapy that could be as much as 22 percent more effective at killing cancer cells than current standard radiation treatment ...

Artificial Intelligence Approach May Help Identify Melanoma Survivors Who Face a High Risk of Cancer Recurrence

Oct. 31, 2022 — Researchers have developed and validated a machine learning--based method to predict which patients with early-stage melanoma are most likely to experience a cancer ...

Reprogramming of Immune Cells Shown to Fight Off Melanoma

Oct. 31, 2022 — A new way of reprogramming our immune cells to shrink or kill off cancer cells has been shown to work in the otherwise hard to treat and devastating skin cancer, melanoma. The discovery demonstrates ...

Advanced Melanoma Survival Improves Significantly When Immunotherapy Is Given Before Targeted Therapy

Sep. 28, 2022 — A clinical trial showed a remarkable 20 percent advantage in the two-year overall survival rate for people with advanced melanoma who first received immunotherapy (72 percent survival rate) versus ...

Awakening 'Dormant' Cells to Fight Cancer

Sep. 22, 2022 — The advent of small-molecule targeted therapies, a decade ago, revolutionized the treatment of metastatic melanoma, provided that the tumors carry the mutations to respond to these treatments. ...

Tumors Form Temporary Structures to Avoid Immunotherapy Treatments

Sep. 20, 2022 — Scientists have shown how tumor cells evade immunotherapy by generating unique, temporary cell-in-cell structures, where the inner cells remain in tact and can return to single tumor ...

Researchers Decipher the Mechanism That Enables Skin Cancer to Metastasize to the Brain -- And Inhibited Its Spread by 80 Percent

Sep. 20, 2022 — Researchers have deciphered a mechanism that enables skin cancer to metastasize to the brain and managed to delay the spread of the disease by 60% to 80% using existing ...

Scientists Identify Key Biomarkers That Reliably Predict Response to Immune Checkpoint Inhibitor Therapy for Melanoma

Sep. 19, 2022 — Currently, the only FDA approved biomarker for ICI melanoma treatment is the tumor mutation burden assay, but the mechanisms linking it to ICI remain unclear. However, new research now provides ...

Melanoma Treatment: Potential Target Bypasses Therapeutic Resistance to Immune Checkpoint Blockers

Sep. 19, 2022 — Over the last decade, immune checkpoint blockers, or ICBs, have revolutionized treatment for various advanced cancers, including melanoma, the most aggressive skin cancer that was considered largely ...

Inhibiting Key Metabolic Enzyme Shows Promise Against Melanoma

Sep. 1, 2022 — Researchers have shown that inhibiting a key metabolic enzyme selectively kills melanoma cells and stops tumor growth. The findings could lead to a new class of drugs to selectively treat melanoma, ...

Identifying Melanoma Patients With High-Risk Disease

Aug. 23, 2022 — Medical researchers report on their identification of high-risk patients with stage 3A disease and microscopic lymph node metastases who would benefit from adjuvant ...

Targeted Cancer Vaccines Eliminate Tumors and Prevent Recurrence in Mice

Aug. 15, 2022 — Researchers developed a lipid nanoparticle-delivered cancer vaccine against a mouse model of melanoma that specifically targets the lymph system to generate greater potency. They were able to achieve ...

'RNA Fishing' Reveals New Driver of Melanoma Malignancy and Metastasis

Aug. 3, 2022 — Researchers have identified several proteins involved in the progression of melanoma. One of the proteins -- PDIA6 -- was found to be particularly important for driving malignancy. Experiments with ...

Melanoma Thickness Equally Hard for Algorithms and Dermatologists to Judge

July 20, 2022 — Assessing the thickness of melanoma is difficult, whether done by an experienced dermatologist or a well-trained machine-learning algorithm. A study shows that the algorithm and the dermatologists ...

New Insights Into Melanoma Brain Metastases

July 15, 2022 — Cancer researchers have completed one of the most comprehensive studies of the cells inside melanoma brain ...

Monday, June 26, 2023