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'Coral on a chip' cracks coral mysteries

March 16, 2016
Weizmann Institute of Science
The world’s corals are dying, with tremendous effects on climate and ocean health – however, much about why coral dies is still unknown. Now, a team of researchers has created a new experimental platform – a “coral on a chip” – that lets them grow coral in the lab to study the structures’ complicated lives at microscale resolution.

We know that human-induced environmental changes are responsible for coral bleaching, disease, and infertility. Loss of the world's stony coral reefs -- up to 30% in the next 30 years, according to some estimates -- will mean loss of their services, including sequestering some 70-90 million tons of carbon each year and supporting enormous marine biodiversity. Yet despite many advances, we are still far from understanding the causes and processes contributing to the corals' demise. Weizmann Institute of Science researchers have developed a new experimental platform for studying coral biology at microscale resolutions, which is already providing new insights into this complex problem. The work was published in Nature Communications.

The tiny -- often less than a millimeter in diameter -- animals that build coral reefs create a thin layer of living tissue surrounding the calcium-based skeleton. These animals live in symbiosis with single-celled, photosynthetic algae that provide nutrients and oxygen in return for carbon dioxide and shelter. "In order to understand what happens during bleaching, when this symbiosis is broken," says Dr. Assaf Vardi, "we need to understand what happens to these organisms at the cellular and molecular levels under various conditions."

Dr. Vardi and his team -- Orr Shapiro, Esti Kramarsky-Winter, and Assaf R. Gavish, all of the Institute's Department of Plant and Environmental Sciences -- together with Roman Stocker of MIT (currently at ETH, the Swiss Federal Institute of Technology) created a system they call "coral on a chip." For the first time, the scientists were able to examine living coral polyps in the lab, under highly controlled conditions. This system is based on microfluidics technology, which had been developed to track cellular processes under lifelike conditions. Taking a small piece of coral, Dr. Vardi and his team induced stressful conditions -- in this case by increasing salt content -- that caused the corals to release polyps, a process sometimes referred to as "polyp bailout." Settling the bailed-out polyps into prefabricated microfluidic wells, the scientists were able to observe, via continuous observation under a microscope, how miniature coral colonies called "micropropagates" grow and behave in different conditions.

Using their system, the team recorded, for the first time, the growth of individual aragonite crystals -- the basic building blocks of the coral skeleton. The group was also able to directly visualize the initiation of coral disease, pointing to a little-known path of infection. Subjecting coral micropropagates to high light intensities, known to induce coral bleaching, enabled the team to follow the elimination of the symbiotic algae, one cell at a time.

Dr. Vardi's lab group is already in the process of adapting the coral-on-a-chip system to track the nutrient and carbon cycles of reef-building corals, as well as delving further into disease and bleaching processes. "Many corals are running out of time; it is crucial to know how our actions are affecting their survival, and how they affect ours," he says. "Our method can help researchers investigate everything from the coral genes that affect survival, to the strategies coral use to build reefs, to their effects on the marine carbon cycle."

Indeed, as corals represent an early stage in the evolution of multicellular organisms, Dr. Vardi envisions the coral-on-a-chip platform establishing coral micropropagates as a new model system for research.

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Materials provided by Weizmann Institute of Science. Note: Content may be edited for style and length.

Journal Reference:

  1. Orr H. Shapiro, Esti Kramarsky-Winter, Assaf R. Gavish, Roman Stocker, Assaf Vardi. A coral-on-a-chip microfluidic platform enabling live-imaging microscopy of reef-building corals. Nature Communications, 2016; 7: 10860 DOI: 10.1038/ncomms10860

Cite This Page:

Weizmann Institute of Science. "'Coral on a chip' cracks coral mysteries." ScienceDaily. ScienceDaily, 16 March 2016. <>.
Weizmann Institute of Science. (2016, March 16). 'Coral on a chip' cracks coral mysteries. ScienceDaily. Retrieved July 24, 2024 from
Weizmann Institute of Science. "'Coral on a chip' cracks coral mysteries." ScienceDaily. (accessed July 24, 2024).

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