Featured Research

from universities, journals, and other organizations

Hopkins AIDS Network Studies How Well Early, Aggressive Treatment of HIV Infection Works

Date:
September 25, 1997
Source:
Johns Hopkins Medical Institutions
Summary:
Johns Hopkins AIDS researchers have launched a multi-center study to find out if early, aggressive treatment of HIV infection can reduce virus levels or even eliminate the virus. The study also will examine the effect of this treatment approach on the immune system during the first few months of infection.

Johns Hopkins AIDS researchers have launched a multi-center study to find out if early, aggressive treatment of HIV infection can reduce virus levels or even eliminate the virus. The study also will examine the effect of this treatment approach on the immune system during the first few months of infection. Funded by the National Institutes of Health, the research could lead to improved treatments and more effective vaccines.

Related Articles


"We have very little information about the early stages of HIV infection," says Richard Chaisson, M.D., associate professor of medicine and director of the Johns Hopkins AIDS Service. Chaisson is a co-investigator for the project, which is led by Joseph B. Margolick, M.D., Ph.D., associate professor of molecular microbiology and immunology at the Johns Hopkins School of Public Health.

"Most people who are HIV-positive don't even know it until they are tested for the virus years after becoming infected," notes Chaisson.

The study will measure how effectively combination drug therapy works during the early stages of infection with HIV. In combination therapy, newly developed anti-HIV drugs called protease inhibitors are combined with older drugs, such as AZT and ddI, to give a double punch against the AIDS virus.

The researchers want to learn if early, aggressive, combination therapy only reduces or actually eliminates HIV from the body. The researchers also hope to determine how long anti-HIV drugs need to be taken for maximum benefit. "We'd like to know whether we can reduce the damage caused by HIV infection if we start treatment early," says Chaisson.

Another important goal is to determine how early HIV infection affects the activity of two important chemicals that help stimulate the immune system--interleukin-2 (IL-2) and interleukin-12 (IL-12). IL-2 and IL-12 stimulate the growth and functions of the immune system cells that HIV-1 kills, according to Margolick.

"We are going to treat some of the patients with IL-2 to see if we can repair some of the damage the virus does to helper T cells during the first few months of infection," Margolick says. Helper T cells are white blood cells that regulate the immune system's response to infection. They are a major target of the AIDS virus.

The study will recruit up to 50 individuals in the first year, primarily intravenous drug users, who were infected within six months of entering the program.

Other institutions participating in this project include the University of Pittsburgh and Cornell University Medical College (New York, N.Y.).

The Hopkins study is one of several being done across the country. Other institutions conducting similar studies include the University of California, San Francisco; University of Alabama; University of Colorado; University of Washington; and the Aaron Diamond Center (New York, N.Y.).


Story Source:

The above story is based on materials provided by Johns Hopkins Medical Institutions. Note: Materials may be edited for content and length.


Cite This Page:

Johns Hopkins Medical Institutions. "Hopkins AIDS Network Studies How Well Early, Aggressive Treatment of HIV Infection Works." ScienceDaily. ScienceDaily, 25 September 1997. <www.sciencedaily.com/releases/1997/09/970925042413.htm>.
Johns Hopkins Medical Institutions. (1997, September 25). Hopkins AIDS Network Studies How Well Early, Aggressive Treatment of HIV Infection Works. ScienceDaily. Retrieved November 23, 2014 from www.sciencedaily.com/releases/1997/09/970925042413.htm
Johns Hopkins Medical Institutions. "Hopkins AIDS Network Studies How Well Early, Aggressive Treatment of HIV Infection Works." ScienceDaily. www.sciencedaily.com/releases/1997/09/970925042413.htm (accessed November 23, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Sunday, November 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com
Raw: Paralyzed Marine Walks With Robotic Braces

Raw: Paralyzed Marine Walks With Robotic Braces

AP (Nov. 21, 2014) Marine Corps officials say a special operations officer left paralyzed by a sniper's bullet in Afghanistan walked using robotic leg braces in a ceremony to award him a Bronze Star. (Nov. 21) Video provided by AP
Powered by NewsLook.com
Milestone Birthdays Can Bring Existential Crisis, Study Says

Milestone Birthdays Can Bring Existential Crisis, Study Says

Newsy (Nov. 21, 2014) Researchers find that as people approach new decades in their lives they make bigger life decisions. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins