Featured Research

from universities, journals, and other organizations

Gene Found That Protects Against Heart Disease

Date:
January 22, 1998
Source:
American Heart Association
Summary:
A gene that appears to provide protection against coronary artery disease (CAD), the cause of heart attacks, has been identified by Japanese researchers, according to a report in the Jan. 20 issue of Circulation: Journal of the American Heart Association.

DALLAS, Jan. 20 -- A gene that appears to provide protection against coronary artery disease (CAD), the cause of heart attacks, has been identified by Japanese researchers, according to a report in today's Circulation: Journal of the American Heart Association.

In a study of more than 400 people in Japan, individuals with a variant form of the p22 phox gene were found to be at lower risk for CAD, say the report's authors Nobutaka Inoue, M.D., and Seinosuke Kawashima, M.D., of the Kobe University School of Medicine, Kobe, Japan.

The p22 phox gene is expressed in the blood vessel, and it has some variation, that is polymorphism, at four sites including active site. The gene affects production of free radicals that oxidize low-density lipoproteins (LDL), the bad form of cholesterol. Oxidized LDL can stick to and damage the artery walls and create plaque buildup. Over time, the plaque build-up can clog blood vessels, setting the stage for a heart attack or stroke.

Researchers found that the variant type of the gene may help prevent oxidation, rather than promote it.

The prevalence of the variant form of the active site was studied in 201 patients with CAD and in 201 "controls," individuals without CAD. It was found in 53 healthy individuals and 28 individuals with CAD.

Compared to individuals with CAD, healthy controls were 49 percent more likely to have the variant form of the active site of this gene, reports the researchers, "indicating that the gene might have a protective effect on heart attack risk." The polymorphism of the other sites occurred at equal rates among healthy individuals and patients.

Studies on a larger population and other ethnic groups will be required to determine whether the variant form of the gene might provide a genetic marker and help determine which individuals are more prone to develop CAD.

Co-authors of the study include Kenji Kanazawa, M.D.; Shinichiro Yamada, M.D.; Hozuka Akita, M.D., and Mitshuhiro Yokoyama, M.D.


Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


Cite This Page:

American Heart Association. "Gene Found That Protects Against Heart Disease." ScienceDaily. ScienceDaily, 22 January 1998. <www.sciencedaily.com/releases/1998/01/980122060824.htm>.
American Heart Association. (1998, January 22). Gene Found That Protects Against Heart Disease. ScienceDaily. Retrieved September 21, 2014 from www.sciencedaily.com/releases/1998/01/980122060824.htm
American Heart Association. "Gene Found That Protects Against Heart Disease." ScienceDaily. www.sciencedaily.com/releases/1998/01/980122060824.htm (accessed September 21, 2014).

Share This



More Health & Medicine News

Sunday, September 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sierra Leone's Nationwide Ebola Curfew Underway

Sierra Leone's Nationwide Ebola Curfew Underway

Newsy (Sep. 20, 2014) Sierra Leone is locked down as aid workers and volunteers look for new cases of Ebola. Video provided by Newsy
Powered by NewsLook.com
Changes Found In Brain After One Dose Of Antidepressants

Changes Found In Brain After One Dose Of Antidepressants

Newsy (Sep. 19, 2014) A study suggest antidepressants can kick in much sooner than previously thought. Video provided by Newsy
Powered by NewsLook.com
Could Grief Affect The Immune Systems Of Senior Citizens?

Could Grief Affect The Immune Systems Of Senior Citizens?

Newsy (Sep. 19, 2014) The study found elderly people are much more likely to become susceptible to infection than younger adults going though a similar situation. Video provided by Newsy
Powered by NewsLook.com
Jury Delivers Verdict in Salmonella Trial

Jury Delivers Verdict in Salmonella Trial

AP (Sep. 19, 2014) A federal jury has convicted three people in connection with an outbreak of salmonella poisoning five years ago that sickened hundreds of people and was linked to a number of deaths. (Sept. 19) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins