Featured Research

from universities, journals, and other organizations

Researchers Synthesize Compounds For New Class Of Antibiotics

Date:
May 13, 1998
Source:
Boston University
Summary:
Researchers at Boston University and Scriptgen Pharmaceuticals, Inc., have successfully synthesized two compounds that open the door to the development of an entirely new class of antibiotics for use against today's increasingly drug-resistant bacteria as well as emerging forms of bacteria.

(Boston, Mass.) -- Researchers at Boston University and Scriptgen Pharmaceuticals, Inc., have successfully synthesized two compounds that open the door to the development of an entirely new class of antibiotics for use against today's increasingly drug-resistant bacteria as well as emerging forms of bacteria.

Related Articles


In a recent issue of the Journal of Organic Chemistry, the research team reported that they have chemically synthesized myxopyronin A and B, two natural compounds known to block replication of drug-resistant strains of bacteria. Before this breakthrough, the compounds could only be isolated from their bacterial source, a process that yielded quantities too small to be usable.

From a therapeutic standpoint, the compounds look particularly promising because of their selectivity. Harmful bacteria contain DNA-dependent polymerase enzymes, as do humans. Myxopyronin A and B attack the bacterial enzymes while leaving the human host alone.

In recent years, the incidence of infectious diseases has soared, along with deaths resulting from them. At the same time, the need for new antibiotics has risen steadily as bacteria have developed a resistance to existing drugs. The worldwide market for anti-infective drugs is now estimated to be $34 billion, and it is still growing.

"This is an exciting opportunity for the development of a new type of antibiotic," says James Panek, a professor of chemistry who led Boston University's participation in the project. "The chemical synthesis provides us with the means for generating the materials that can lead to new pharmaceuticals."

Scriptgen, a Waltham, MA, company that develops drugs to control the expression of genes, is now developing the processes for converting the raw materials of myxopyronin A and B into viable antibiotics.

"This is a significant breakthrough from a chemistry point of view, but it's the first step in the process, " said Michael G. Palfreyman, Vice President of Research and Development at Scriptgen. "Now we need to take myxopyronin and make it more drug-like. The synthesis was designed to allow us to make many analogs--many different candidates--so that doctors can choose the best one for the desired activity."


Story Source:

The above story is based on materials provided by Boston University. Note: Materials may be edited for content and length.


Cite This Page:

Boston University. "Researchers Synthesize Compounds For New Class Of Antibiotics." ScienceDaily. ScienceDaily, 13 May 1998. <www.sciencedaily.com/releases/1998/05/980513080643.htm>.
Boston University. (1998, May 13). Researchers Synthesize Compounds For New Class Of Antibiotics. ScienceDaily. Retrieved November 24, 2014 from www.sciencedaily.com/releases/1998/05/980513080643.htm
Boston University. "Researchers Synthesize Compounds For New Class Of Antibiotics." ScienceDaily. www.sciencedaily.com/releases/1998/05/980513080643.htm (accessed November 24, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, November 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
Don't Fall For Flu Shot Myths

Don't Fall For Flu Shot Myths

Newsy (Nov. 23, 2014) Misconceptions abound when it comes to your annual flu shot. Medical experts say most people older than 6 months should get the shot. Video provided by Newsy
Powered by NewsLook.com
WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins