Featured Research

from universities, journals, and other organizations

Powerful AIDS Drugs May Promote Heart Disease

Date:
July 6, 1998
Source:
Brown University
Summary:
Drug cocktails may prevent early deaths from the HIV virus, but they also may contribute to a longer-term risk of heart disease. Brown University researchers have confirmed two independent cardiovascular disease risk factors in some women: disfiguring extra fat around the torso and potentially harmful serum lipid levels.

PROVIDENCE, R.I. -- Drug cocktails may prevent early deaths from the HIV virus, but they also may contribute to a longer-term risk of heart disease. Brown University researchers have confirmed two independent cardiovascular disease risk factors in some women: disfiguring extra fat around the torso and potentially harmful serum lipid levels.

The drugs seemed to impact two of four measured lipid levels, increasing only the cholesterol and low-density lipoproteins (LDL). In eight women, high triglycerides and a deficit of protective high-density lipoproteins (HDL) - both thought to be additional drug side effects - were found to be preexisting conditions. This study did not identify the culprit, but all the women had taken cocktails containing protease inhibitors.

The study also documented another side effect. Of 116 women who were treated with the popular drug protocol at the Miriam Hospital Immunology Center in Providence, R.I., 21 complained of the body fat changes, some as early as six weeks into therapy. The women developed prominent pregnant-looking bellies, enlarged breasts and in some cases "buffalo hump" fat pads on the back, while fat wasted away from their arms, legs and buttocks.

"As the available therapies are allowing people to live longer, we need to consider their risk of common diseases, and it certainly must be clarified whether specific therapies are putting patients at increased risk for these systemic diseases," says lead author Krista Dong, M.D., a medical resident at Strong Memorial Hospital in Rochester, N.Y., who completed this study while in medical school at Brown. The researchers hope that two new drugs, which may be available this fall, will prove equally effective in controlling the AIDS virus but without the undesirable side effects on fat metabolism.


Story Source:

The above story is based on materials provided by Brown University. Note: Materials may be edited for content and length.


Cite This Page:

Brown University. "Powerful AIDS Drugs May Promote Heart Disease." ScienceDaily. ScienceDaily, 6 July 1998. <www.sciencedaily.com/releases/1998/07/980706080909.htm>.
Brown University. (1998, July 6). Powerful AIDS Drugs May Promote Heart Disease. ScienceDaily. Retrieved August 1, 2014 from www.sciencedaily.com/releases/1998/07/980706080909.htm
Brown University. "Powerful AIDS Drugs May Promote Heart Disease." ScienceDaily. www.sciencedaily.com/releases/1998/07/980706080909.htm (accessed August 1, 2014).

Share This




More Health & Medicine News

Friday, August 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins