Featured Research

from universities, journals, and other organizations

Scientists Closer To Locating Gene That May Explain Cholesterol Absorption

Date:
September 4, 1998
Source:
University Of Texas Southwestern Medical Center At Dallas
Summary:
In a discovery that may shed light on why people absorb cholesterol at different rates, scientists from UT Southwestern Medical Center at Dallas and the National Institutes of Health have narrowed their search for a gene responsible for abnormal cholesterol absorption in individuals with a rare hereditary disease.

DALLAS--September 1, 1998--In a discovery that may shed light on why people absorb cholesterol at different rates, scientists from UT Southwestern Medical Center at Dallas and the National Institutes of Health have narrowed their search for a gene responsible for abnormal cholesterol absorption in individuals with a rare hereditary disease.

Related Articles


While cholesterol metabolism has been well-documented, scientists understand little about how cholesterol is absorbed from our diet and excreted by the body.

"Only a fraction of the cholesterol we consume is actually absorbed by the body," said Dr. Shailendra Patel, assistant professor of clinical nutrition and a scholar in the Center for Human Nutrition at UT Southwestern. "Different people absorb different amounts. Some might eat a cholesterol-laden meal and absorb 30 percent of it; someone else might eat a low-cholesterol meal but absorb 60 percent of it."

The researchers studied 10 families with sistosterolemia, a rare, recessively inherited disease characterized by the accumulation of plant sterols, premature heart disease and fatty deposits on the skin and tendons. Plant sterol is akin to cholesterol in animal products but normally is not absorbed by the body.

"In normal individuals, the body has the ability to selectively absorb cholesterol and exclude plant sterols,"said Patel, lead author of the study published in the Sept. 1 issue of the Journal of Clinical Investigation. "Individuals with sistosterolemia hyperabsorb cholesterol, but also absorb plant and shellfish sterols that are not normally absorbed. Hence, the gene that is disrupted may regulate selective absorption of dietary cholesterol.

"If we wanted to change someone's cholesterol absorption, this gene would be the target of treatment," Patel said. "We hope this is the key gene that will allow us to target cholesterol absorption as a whole new form of drug therapy."

"Our studies of sitosterolemia may help explain the mechanisms responsible for cholesterol uptake from the diet and on mechanisms that protects us from absorbing and retaining substances in food that are potentially harmful," said co-author Dr. Michael Brownstein, chief of the NIH's Section on Genetics: People Investigating Genes.

The researchers examined the genes of families from India, Finland, the Netherlands, Japan and the United States and mapped the genetic defect to chromosome 2p21.

Other researchers participating in the study included Dr. Scott Grundy, professor of internal medicine and director of the Center for Human Nutrition at UT Southwestern; Mi-Hye Lee, a fellow in the nutrition center; Dr. Gerald Salen of UMDNJ-New Jersey Medical School; and researchers from Shiga University of Medical Science (Japan), Johns Hopkins Hospital, University Hospital Jijmegen (The Netherlands) and University Hospital Helsinki (Finland).

The study was supported in part by grants from the Department of Veterans Affairs, U.S. Public Health Service, Ministry of Education (Japan), American Heart Association, Southwestern Medical Foundation and the Moss Heart Foundation (Dallas).


Story Source:

The above story is based on materials provided by University Of Texas Southwestern Medical Center At Dallas. Note: Materials may be edited for content and length.


Cite This Page:

University Of Texas Southwestern Medical Center At Dallas. "Scientists Closer To Locating Gene That May Explain Cholesterol Absorption." ScienceDaily. ScienceDaily, 4 September 1998. <www.sciencedaily.com/releases/1998/09/980904035756.htm>.
University Of Texas Southwestern Medical Center At Dallas. (1998, September 4). Scientists Closer To Locating Gene That May Explain Cholesterol Absorption. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/1998/09/980904035756.htm
University Of Texas Southwestern Medical Center At Dallas. "Scientists Closer To Locating Gene That May Explain Cholesterol Absorption." ScienceDaily. www.sciencedaily.com/releases/1998/09/980904035756.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
Today's Prostheses Are More Capable Than Ever

Today's Prostheses Are More Capable Than Ever

Newsy (Nov. 26, 2014) Advances in prosthetics are making replacement body parts stronger and more lifelike than they’ve ever been. Video provided by Newsy
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins