Featured Research

from universities, journals, and other organizations

Doctors Reverse Kidney Failure In An HIV-Infected Patient

Date:
September 18, 1998
Source:
University Of Maryland Medical Center
Summary:
In the first documented case of its kind, doctors at the University of Maryland Medical Center have been able to reverse kidney failure in an HIV-infected patient by putting the patient on highly active, triple-drug antiretroviral therapy.

In the first documented case of its kind, doctors at the University of Maryland Medical Center have been able to reverse kidney failure in an HIV-infected patient by putting the patient on highly active, triple-drug antiretroviral therapy. This case, published in the September 5, 1998, issue of The Lancet, provides the first evidence of a connection between highly active antiretroviral therapy and a dramatic improvement in kidney function in an AIDS patient who had started dialysis. It also suggests that the therapy may eliminate the need for long-term dialysis in HIV patients, although more study is needed.

Related Articles


"It has been the feeling among doctors who treat HIV patients that current antiretroviral therapy may help prevent kidney failure, but it had never been documented," said Emilio Ramos, M.D., a nephrologist at the University of Maryland Medical Center and associate professor at the University of Maryland School of Medicine. "Now we are beginning a study to look at patients with HIV and kidney disease to determine whether they could benefit from highly active antiretroviral therapy."

About 10 percent of patients with HIV infection develop kidney failure. Dr. Ramos says the antiretroviral therapy will not reverse kidney failure in patients who have been on dialysis for a long time and whose kidneys have deteriorated. He believes it is most effective in the early stages of kidney failure, as was the case with this particular patient.

The patient, a 37-year-old African-American male, was unaware of his HIV status when he first came to the medical center. A kidney biopsy revealed that his kidney failure was HIV-related. One week before going on dialysis, he was put on therapy of 20 mg of stavudine a day, 50 mg of larnivudine a day and 1,250 mg of nelfinavir twice daily.

Thirteen weeks later, the patient's kidneys regained normal function and hemodialysis was stopped. In addition, the patient's viral load decreased from more than 900,000 copies/ml to 500 copies/ml. A repeat kidney biopsy also revealed that inflammation on the kidney had almost completely disappeared.

"This case is encouraging, because it implies that even a late stage complication of HIV, such as kidney failure, can be reversed with these powerful drugs. It provides more hope for our patients," says Lori Fantry, M.D., an AIDS specialist at the University of Maryland Medical Center and assistant professor of medicine at the University of Maryland School of Medicine.

"Antiviral medications cost about $10,000 per year. They are very expensive but keeping a patient on dialysis for the rest of his life is also very costly," says Ravinder K. Wali, M.D., lead author of the article and fellow in the Division of Nephrology at the University of Maryland Medical Center. "This case showed that therapy may eliminate the need for long-term dialysis in some HIV patients." Dialysis costs more than $40,000 per year.


Story Source:

The above story is based on materials provided by University Of Maryland Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

University Of Maryland Medical Center. "Doctors Reverse Kidney Failure In An HIV-Infected Patient." ScienceDaily. ScienceDaily, 18 September 1998. <www.sciencedaily.com/releases/1998/09/980918071441.htm>.
University Of Maryland Medical Center. (1998, September 18). Doctors Reverse Kidney Failure In An HIV-Infected Patient. ScienceDaily. Retrieved April 18, 2015 from www.sciencedaily.com/releases/1998/09/980918071441.htm
University Of Maryland Medical Center. "Doctors Reverse Kidney Failure In An HIV-Infected Patient." ScienceDaily. www.sciencedaily.com/releases/1998/09/980918071441.htm (accessed April 18, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, April 18, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Our Love Of Puppy Dog Eyes Explained By Science

Our Love Of Puppy Dog Eyes Explained By Science

Newsy (Apr. 17, 2015) Researchers found a spike in oxytocin occurs in both humans and dogs when they gaze into each other&apos;s eyes. Video provided by Newsy
Powered by NewsLook.com
Scientists Find Link Between Gestational Diabetes And Autism

Scientists Find Link Between Gestational Diabetes And Autism

Newsy (Apr. 17, 2015) Researchers who analyzed data from over 300,000 kids and their mothers say they&apos;ve found a link between gestational diabetes and autism. Video provided by Newsy
Powered by NewsLook.com
Video Messages Help Reassure Dementia Patients

Video Messages Help Reassure Dementia Patients

AP (Apr. 17, 2015) Family members are prerecording messages as part of a unique pilot program at the Hebrew Home in New York. The videos are trying to help victims of Alzheimer&apos;s disease and other forms of dementia break through the morning fog of forgetfulness. (April 17) Video provided by AP
Powered by NewsLook.com
Boy or Girl? Intersex Awareness Is on the Rise

Boy or Girl? Intersex Awareness Is on the Rise

AP (Apr. 17, 2015) At least 1 in 5,000 U.S. babies are born each year with intersex conditions _ ambiguous genitals because of genetic glitches or hormone problems. Secrecy and surgery are common. But some doctors and activists are trying to change things. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins