Featured Research

from universities, journals, and other organizations

Researchers Report Emergence Of Antibiotic Resistance During Vancomycin Therapy

Date:
February 19, 1999
Source:
The Rockefeller University
Summary:
A team of researchers led by The Rockefeller University's Alexander Tomasz, Ph.D., have described the case of a 79-year-old patient whose death in a New York metropolitan area hospital last March was associated with a bloodstream infection caused by a multidrug-resistant strain of Staphylococcus aureus. The report, published in the Feb. 18 issue of the New England Journal of Medicine (NEJM), showed that the bacteria, which had decreased susceptibility to vancomycin, could be treated effectively with a combination of antibiotics.

Antibiotic Combination Shown To Be Effective against Resistant Bug

Related Articles


A team of researchers led by The Rockefeller University's Alexander Tomasz, Ph.D., have described the case of a 79-year-old patient whose death in a New York metropolitan area hospital last March was associated with a bloodstream infection caused by a multidrug-resistant strain of Staphylococcus aureus. The report, published in the Feb. 18 issue of the New England Journal of Medicine (NEJM), showed that the bacteria, which had decreased susceptibility to vancomycin, could be treated effectively with a combination of antibiotics.

"We think that this is the first demonstration that selection for strains with increased resistance to vancomycin can occur during therapy," says Tomasz, senior author of the paper and professor and head of the Laboratory of Microbiology.

The case described in the NEJM article was the fourth in the world associated with infections caused by multiresistant strains of Staphylococcus aureus (MRSA) that also show partial resistance to vancomycin, a drug often described as the "last resort" antibiotic against these dangerous pathogens that cause many hospital-acquired infections in the United States and elsewhere.

"The emergence of vancomycin-resistant Staphylococcus aureus strains emphasizes the importance of appropriate vancomycin dosing to assure complete eradication of the bacteria," says Richard B. Roberts, M.D., a co-author of the report and an adjunct professor at Rockefeller and professor of medicine at New York Hospital-Cornell Medical Center.

A hopeful finding reported by the Rockefeller team is that a combination of two commonly used antibiotics, oxacillin and vancomycin, produced a synergistic effect and killed the vancomycin-resistant MRSA very efficiently in the test tube.

"If these results can be translated into the clinical setting, they suggest that a combination of vancomycin and oxacillin may be an effective therapeutic regimen against vancomycin-resistant staphylococci," says Tomasz.

Antibiotic resistance is a growing public health problem. In a study published in the July 1998 issue of the Journal of Infectious Diseases, the Rockefeller group in collaboration with colleagues at the Public Health Research Institute used molecular fingerprinting techniques to demonstrate the extensive spread of a single multidrug-resistant Staphylococcus aureus strain dubbed "the New York clone of MRSA" in 12 hospitals in the New York metropolitan area.

Tomasz and Roberts's co-authors are first author Krzysztof Sieradzki, Ph.D., a postdoctoral fellow at Rockefeller, and Stuart W. Haber, M.D., of United Hospital Medical Center in Port Chester, N.Y.

The research described in the NEJM paper was supported in part by The Glickenhaus Foundation, The Bodman and Achelis Foundations, and the Cary L. Guy Foundation.

Rockefeller began in 1901 as The Rockefeller Institute for Medical Research, the first U.S. biomedical research center. Rockefeller faculty members have made significant achievements, including the discovery that DNA is the carrier of genetic information and the launching of the scientific field of modern cell biology. The university has ties to 19 Nobel laureates. Thirty-three faculty members are elected members of the U.S. National Academy of Sciences, including President Arnold J. Levine, Ph.D.


Story Source:

The above story is based on materials provided by The Rockefeller University. Note: Materials may be edited for content and length.


Cite This Page:

The Rockefeller University. "Researchers Report Emergence Of Antibiotic Resistance During Vancomycin Therapy." ScienceDaily. ScienceDaily, 19 February 1999. <www.sciencedaily.com/releases/1999/02/990219080817.htm>.
The Rockefeller University. (1999, February 19). Researchers Report Emergence Of Antibiotic Resistance During Vancomycin Therapy. ScienceDaily. Retrieved November 24, 2014 from www.sciencedaily.com/releases/1999/02/990219080817.htm
The Rockefeller University. "Researchers Report Emergence Of Antibiotic Resistance During Vancomycin Therapy." ScienceDaily. www.sciencedaily.com/releases/1999/02/990219080817.htm (accessed November 24, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, November 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Winter Can Cause Depression — Here's How To Combat It

Winter Can Cause Depression — Here's How To Combat It

Newsy (Nov. 23, 2014) Millions of American suffer from seasonal depression every year. It can lead to adverse health effects, but there are ways to ease symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
Don't Fall For Flu Shot Myths

Don't Fall For Flu Shot Myths

Newsy (Nov. 23, 2014) Misconceptions abound when it comes to your annual flu shot. Medical experts say most people older than 6 months should get the shot. Video provided by Newsy
Powered by NewsLook.com
WFP: Ebola Risks Heightened Among Women Throughout Africa

WFP: Ebola Risks Heightened Among Women Throughout Africa

AFP (Nov. 21, 2014) Having children has always been a frightening prospect in Sierra Leone, the world's most dangerous place to give birth, but Ebola has presented an alarming new threat for expectant mothers. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins