Featured Research

from universities, journals, and other organizations

University Of Illinois At Chicago Pharmacy Researcher Discovers Similarity Between Rats And Humans

Date:
March 11, 1999
Source:
University Of Illinois At Chicago
Summary:
The recent finding by a researcher at the University of Illinois at Chicago that humans and rats absorb and eliminate some drugs at the same rate may have a dramatic impact on future drug development.

Tests suggest rats may be more useful than monkeys in some types of drug studies

The recent finding by a researcher at the University of Illinois at Chicago that humans and rats absorb and eliminate some drugs at the same rate may have a dramatic impact on future drug development.

The ability to predict the amount of drug absorption and rate of drug elimination in humans is vital for determining safe and effective dosages. It also may lower the cost of drug development by eliminating the need to test potential drugs on multiple animal species and animals that are more expensive than rats, said the UIC researcher, Win Chiou, professor of pharmacokinetics. He found that people and the rodents absorbed 64 drugs and eliminated 54 drugs at a similar rate.

To satisfy a Food and Drug Administration requirement, pharmaceutical companies generally test new drugs on three to six animal species before conducting human trials. Chiou, a researcher in the UIC College of Pharmacy, said his finding suggests that testing new drugs on rats and one other species may be sufficient.

The similarities in drug absorption and elimination in humans and rats is, he said, "very intriguing." If, for example, the absorption of one of the drugs tested is 20 percent in a rat, it will be close to 20 percent in a human, even though humans weigh up to 300 times as much as rats, Chiou discovered. Human intestines also are up to 10 times bigger and many times longer than rat intestines.

"Monkeys are very similar to humans, but they probably are not as useful for drug absorption studies as rats," Chiou said.

Chiou explained that the basic intestinal structures of rats and humans are similar despite the disparities in length and diameter. He and his team now are comparing drug absorption in humans and rats at multiple intestinal sites. They also are systematically comparing the ability to predict drug absorption and elimination using dogs and other traditional methods. Chiou said that his team's preliminary studies and evaluation of scientific literature indicate that dogs often are poor absorption models for humans.

The FDA and pharmaceutical companies in the United States and abroad have invited Chiou to discuss his findings. Chiou will present his research this fall at the International Pharmaceutical Federation meeting in Barcelona, Spain, and the Southeast Asian-Western Pacific Regional Meeting of Pharmacologists in Taipei, Taiwan.


Story Source:

The above story is based on materials provided by University Of Illinois At Chicago. Note: Materials may be edited for content and length.


Cite This Page:

University Of Illinois At Chicago. "University Of Illinois At Chicago Pharmacy Researcher Discovers Similarity Between Rats And Humans." ScienceDaily. ScienceDaily, 11 March 1999. <www.sciencedaily.com/releases/1999/03/990310125639.htm>.
University Of Illinois At Chicago. (1999, March 11). University Of Illinois At Chicago Pharmacy Researcher Discovers Similarity Between Rats And Humans. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/1999/03/990310125639.htm
University Of Illinois At Chicago. "University Of Illinois At Chicago Pharmacy Researcher Discovers Similarity Between Rats And Humans." ScienceDaily. www.sciencedaily.com/releases/1999/03/990310125639.htm (accessed October 21, 2014).

Share This



More Health & Medicine News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

CDC Revamps Ebola Guidelines After Criticism

CDC Revamps Ebola Guidelines After Criticism

Newsy (Oct. 21, 2014) The Centers for Disease Control and Prevention have issued new protocols for healthcare workers interacting with Ebola patients. Video provided by Newsy
Powered by NewsLook.com
WHO: Ebola Vaccine Trials to Start a in January

WHO: Ebola Vaccine Trials to Start a in January

AP (Oct. 21, 2014) Tens of thousands of doses of experimental Ebola vaccines could be available for "real-world" testing in West Africa as soon as January as long as they are deemed safe in soon to start trials, the World Health Organization said Tuesday. (Oct. 21) Video provided by AP
Powered by NewsLook.com
First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

First-Of-Its-Kind Treatment Gives Man Ability To Walk Again

Newsy (Oct. 21, 2014) A medical team has for the first time given a man the ability to walk again after transplanting cells from his brain onto his severed spinal cord. Video provided by Newsy
Powered by NewsLook.com
CDC Issues New Ebola Guidelines for Health Workers

CDC Issues New Ebola Guidelines for Health Workers

Reuters - US Online Video (Oct. 21, 2014) The U.S. Centers for Disease Control and Prevention has set up new guidelines for health workers taking care of patients infected with Ebola. Linda So reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins