Featured Research

from universities, journals, and other organizations

Cedars-Sinai Becomes First Site In California Offering LDL Apheresis To Treat Severe Hypercholesterolemia

Date:
August 30, 1999
Source:
Cedars-Sinai Medical Center
Summary:
While the majority of patients with extremely high LDL cholesterol (also called “bad cholesterol”) can control LDL levels through a combination of diet, exercise and drugs, LDL apheresis, approved for treatment by the FDA earlier this year, can be considered a potentially life-saving therapy for patients who do not respond to other types of treatment. Studies have demonstrated that LDL apheresis can induce the regression of atherosclerosis, improve cardiac perfusion in patients with coronary artery disease, and decrease coronary events in a variety of patients. Cedars-Sinai has become the first site in California to offer LDL apheresis.

LOS ANGELES (August 26, 1999) -- For patients with extremely high LDL cholesterol (also called "bad cholesterol") that does not respond to treatment, Cedars-Sinai has become the first site in California to offer LDL apheresis, a system approved for treatment by the Food and Drug Administration earlier this year.

Related Articles


"Its indications are limited to patients with severe hypercholesterolemia who have not responded to standard therapy, says Timothy A. Denton, M.D., attending cardiologist. "The majority of patients are homozygous and heterozygous familial hypercholesterolemics, or patients who have been tried on at least two cholesterol-lowering agents, but whose LDL cholesterol still remains greater than 200."

According to Dr. Denton, the two- to four-hour therapy usually must be performed one or two times per month for the remainder of a patient's life. Researchers hope, however, that advances in drug therapy may someday allow the frequency of treatments to be reduced.

The technique is similar to plasmapheresis. Blood is separated into plasma and red cells, with the red cells being passed immediately back to the patient. Before the remaining plasma is returned to the patient, it is run through a column that specifically removes LDL cholesterol.

"The concept has existed for 20 years or so but it has become more effective and popular now because of computers and miniaturization. We can perform the procedure and reduce LDL levels very, very effectively now. In fact, dramatic reductions in LDL can be seen with commensurate improvement in cardiovascular outcomes," said Dr. Dennis Goldfinger, Director of Transfusion Medicine -- the section of the hospital that performs the procedure.

For example, studies reported in the medical literature have demonstrated that LDL apheresis can induce the regression of atherosclerosis, improve cardiac perfusion in patients with coronary artery disease, and decrease coronary events in a variety of patients.

While the majority of patients can control LDL levels through a combination of diet, exercise and drugs, LDL apheresis can be considered a potentially life-saving therapy when all else fails.

"The addition of LDL apheresis provides Cedars-Sinai patients with all available technologies for cholesterol management," says P.K. Shah, M.D., Director of Cedars-Sinai’s Division of Cardiology, noting that this technology is available at only 21 sites in the United States.

To determine whether LDL apheresis may be helpful and appropriate in a specific case, a formal screening process is in place to review medical records and perform physical assessments of potential candidates. For additional information about the procedure or to determine if this might be an appropriate treatment option for a patient, call the LDL apheresis center at (310) 967-1861.

# # #

For media information and to arrange an interview, please e-mail [email protected] or call 1-800-396-1002. Thanks for not including media contact information in stories.


Story Source:

The above story is based on materials provided by Cedars-Sinai Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

Cedars-Sinai Medical Center. "Cedars-Sinai Becomes First Site In California Offering LDL Apheresis To Treat Severe Hypercholesterolemia." ScienceDaily. ScienceDaily, 30 August 1999. <www.sciencedaily.com/releases/1999/08/990829174522.htm>.
Cedars-Sinai Medical Center. (1999, August 30). Cedars-Sinai Becomes First Site In California Offering LDL Apheresis To Treat Severe Hypercholesterolemia. ScienceDaily. Retrieved December 22, 2014 from www.sciencedaily.com/releases/1999/08/990829174522.htm
Cedars-Sinai Medical Center. "Cedars-Sinai Becomes First Site In California Offering LDL Apheresis To Treat Severe Hypercholesterolemia." ScienceDaily. www.sciencedaily.com/releases/1999/08/990829174522.htm (accessed December 22, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, December 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Christmas Kissing Good for Health

Christmas Kissing Good for Health

Reuters - Innovations Video Online (Dec. 22, 2014) Scientists in Amsterdam say couples transfer tens of millions of microbes when they kiss, encouraging healthy exposure to bacteria. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Brain-Dwelling Tapeworm Reveals Genetic Secrets

Brain-Dwelling Tapeworm Reveals Genetic Secrets

Reuters - Innovations Video Online (Dec. 22, 2014) Cambridge scientists have unravelled the genetic code of a rare tapeworm that lived inside a patient's brain for at least four year. Researchers hope it will present new opportunities to diagnose and treat this invasive parasite. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Touch-Free Smart Phone Empowers Mobility-Impaired

Touch-Free Smart Phone Empowers Mobility-Impaired

Reuters - Innovations Video Online (Dec. 21, 2014) A touch-free phone developed in Israel enables the mobility-impaired to operate smart phones with just a movement of the head. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com
Earthworms Provide Cancer-Fighting Bacteria

Earthworms Provide Cancer-Fighting Bacteria

Reuters - Innovations Video Online (Dec. 21, 2014) Polish scientists isolate bacteria from earthworm intestines which they say may be used in antibiotics and cancer treatments. Suzannah Butcher reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins