Researchers from the Massachusetts General Hospital (MGH) have for the first time shown that gene therapy may be able to reverse heart failure, one of the major causes of death and disability in North America and Europe. In their study appearing in the December 7 issue of Circulation, the team from the MGH Cardiovascular Research Center (CVRC), along with collaborators from Boston University Medical Center and Imperial College in London, report delivering additional copies of a gene called SERCA2a to muscle cells from failing human hearts. Cells that incorporated the gene and produced elevated levels of its protein began to function in a normal fashion, contracting more quickly and more powerfully.
The above story is based on materials provided by Massachusetts General Hospital. Note: Materials may be edited for content and length.
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