Featured Research

from universities, journals, and other organizations

Mayo Clinic Liver Specialists Testing New Machine That Serves As A Bridge To Transplant For Those With Severe Liver Disease

Date:
January 24, 2000
Source:
Mayo Clinic
Summary:
Mayo Clinic is participating in clinical tests of a new device designed to keep liver transplant candidates alive until organs are available. The device is a bioartificial liver support system similar to a kidney dialysis machine. The technology utilizes pig liver cells to process and metabolize waste products.

ROCHESTER, MINN. - Mayo Clinic is one of two medical centers in the Midwest, and the only center in Minnesota, to participate in clinical tests of a new device designed to keep liver transplant candidates alive until organs are available.

The device is a bioartificial liver support system similar to a kidney dialysis machine. The technology utilizes pig liver cells to process and metabolize waste products. Treatment allows the liver to rest, and in some cases, it reduces or even eliminates the need for transplantation.

With the help of the new bioartificial liver, principle investigator, Scott Nyberg, M.D., Ph.D., hopes Mayo Clinic can help more people get the transplants they need. "It can take seven to ten days for an organ to arrive, but patients with acute liver failure may only last two days," says Dr. Nyberg. "We hope this research will show whether or not this new technology can keep patients alive longer."

In addition to acting as a bridge for patients waiting for transplants, the device will support people who need a second transplant because the first one failed.

The new technology showed promising results in the first phase of tests conducted by Circe Biomedical, Inc. In the first phase of testing, 38 patients were treated successfully. Of that number, 32 were transplanted and six recovered without needing a transplant.

In this second phase of testing patients will be randomized so that half will use the device and half will receive standard intensive care. Patients involved in the study must meet certain criteria. They must have acute, sudden onset liver failure, and have no history of chronic liver disease.

Researchers are testing the device on patients who were healthy, and suddenly, within two months, developed severe liver failure due to causes including viral infection and drug toxicity.

Liver disease results in 40,000 deaths in the United States each year. Of those deaths, 1,400 patients die waiting for liver transplants, often because the organs are not available. Currently, there are 14,000 people on liver transplant waiting lists. Doctors perform approximately 4,000 liver transplants annually.

Dr. Nyberg says the study will evaluate survival and recovery rates of study participants. Thus far, three patients have been treated with the device at Mayo Clinic as part of the clinical trial.

It is estimated that 150 people will participate in the multi-center clinical trial over two years. The clinical trial includes ten sites in the United States, including Mayo Clinic in Rochester, Minnesota, and nine sites in Europe. The U.S. Food and Drug Administration is monitoring the research. The device was developed by Circe Biomedical, Inc., Lexington, Mass.


Story Source:

The above story is based on materials provided by Mayo Clinic. Note: Materials may be edited for content and length.


Cite This Page:

Mayo Clinic. "Mayo Clinic Liver Specialists Testing New Machine That Serves As A Bridge To Transplant For Those With Severe Liver Disease." ScienceDaily. ScienceDaily, 24 January 2000. <www.sciencedaily.com/releases/2000/01/000124074352.htm>.
Mayo Clinic. (2000, January 24). Mayo Clinic Liver Specialists Testing New Machine That Serves As A Bridge To Transplant For Those With Severe Liver Disease. ScienceDaily. Retrieved August 30, 2014 from www.sciencedaily.com/releases/2000/01/000124074352.htm
Mayo Clinic. "Mayo Clinic Liver Specialists Testing New Machine That Serves As A Bridge To Transplant For Those With Severe Liver Disease." ScienceDaily. www.sciencedaily.com/releases/2000/01/000124074352.htm (accessed August 30, 2014).

Share This




More Health & Medicine News

Saturday, August 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

3 Things To Know About The Ebola Outbreak's Progression

3 Things To Know About The Ebola Outbreak's Progression

Newsy (Aug. 29, 2014) Here are three things you need to know about the deadly Ebola outbreak's progression this week. Video provided by Newsy
Powered by NewsLook.com
Killer Amoeba Found in Louisiana Water System

Killer Amoeba Found in Louisiana Water System

AP (Aug. 28, 2014) State health officials say testing has confirmed the presence of a killer amoeba in a water system serving three St. John the Baptist Parish towns. (Aug. 28) Video provided by AP
Powered by NewsLook.com
Who Could Be Burnt by WHO's E-Cigs Move?

Who Could Be Burnt by WHO's E-Cigs Move?

Reuters - Business Video Online (Aug. 28, 2014) The World Health Organisation has called for the regulation of electronic cigarettes as both tobacco and medical products. Ciara Lee looks at the impact of the move on the tobacco industry. Video provided by Reuters
Powered by NewsLook.com
CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

CDC Director On Ebola Outbreak: 'It's Worse Than I Feared'

Newsy (Aug. 28, 2014) CDC director Tom Frieden says the Ebola outbreak is even worse than he feared. But he also said there's still hope to contain it. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins