DALLAS, Feb. 11 -- A new gene therapy tested in mice all but eliminated the fatty plaque deposits that can build up in arteries and cause heart attacks and strokes, according to a study in the February issue of Arteriosclerosis, Thrombosis, and Vascular Biology: Journal of the American Heart Association. Researchers transplanted a gene for the human version of apolipoprotein E (apoE) into a strain of mice bred specifically for the experiment. ApoE is a key protein involved in transporting and clearing cholesterol from the body. The animals getting the apoE gene had significant reductions in total cholesterol and triglycerides, an increased level of beneficial high-density lipoprotein (HDL) cholesterol, and complete regression of the fatty plaque blockages.
The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.
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