Featured Research

from universities, journals, and other organizations

"Obesity Gene" Causes Cancer Of Fat Tissue, Schepens Scientists Find

Date:
April 27, 2000
Source:
Schepens Eye Research Institute
Summary:
A gene previously identified as important in promoting obesity also appears to be responsible for causing a common human tumor, researchers at The Schepens Eye Research Institute have found.

A gene previously identified as important in promoting obesity also appears to be responsible for causing a common human tumor, researchers at The Schepens Eye Research Institute have found.

The gene, known as HMG I-C, causes tumors called lipomas, a common tumor in fat tissue in humans. Lipomas start as benign growths, but can become malignant liposarcomas as they grow. Lipomas are the most common form of mesenchymal tumors found in humans.

"There is now strong evidence that targeting this molecule may be useful both for the treatment of obesity in humans and the treatment of lipomas. It is likely that therapeutic agents which block the expression of the HMG I-C would be effective in the treatment of these two major clinical problems ," said Santa J. Ono, Ph.D., Associate Scientist at The Schepens Eye Research Institute and Associate Professor at Harvard Medical School.

Ono and his colleagues report their findings in The Journal of Biological Chemistry, scheduled for publication on May 12, 2000. The paper has been online at the journal's web site (www.jbc.org) since March 15. Coauthors are Paola Arlotta, Ph.D., and Albert K.-F. Tai, both of The Schepens Eye Research Institute; Guidalberto Manfioletti, Ph.D., University of Trieste, Italy; Charles Clifford, Ph.D., Charles Rivers Laboratories, Wilmington, Mass.; and Gilbert Jay, Ph.D., OriGene Technologies, Rockville, Md.

Previous epidemiologic data had shown that the HMG I-C gene is defective in many mesenchymal tumors. The Ono team has proven a direct role for the HMG I-C gene in lipoma formation by creating transgenic mouse lines that overexpress the defective HMG I-C gene in all cells of the body. The transgenic mice are obese early in life and develop tumors of the adipose (fat) tissue in adult life. About 25 percent of the transgenic mice develop tumors, while control mice, or normal mice, showed no evidence of tumor formation.

The researchers also found that no tumors formed in other tissues of the body, just in fat tissue. However, other researchers in Ono's group have found that the HMG I-C gene also may contribute to human retinoblastomas, a tumor of the eye. "This is really a new type of oncogene, a structural chromosomal protein contributing to tumor formation," Ono said.

Previous research done at the University of Medicine and Dentistry of New Jersey has shown that the HMG I-C gene appears to help mice store fat. Transgenic mice lacking the gene can eat voraciously without getting fat. The Ono team has performed complementary experiments by overexpressing the gene, and noted both obesity and tumor growth.

Ono's research was funded by grants from the National Institutes of Health, the Lucille P. Markey Foundation, the Howard Hughes Medical Institute and the Research to Prevent Blindness Foundation, America.

The Schepens Eye Research Institute, an affiliate of Harvard Medical School, is the largest independent eye research center in the nation, both in size of faculty and support from the National Eye Institute. It has a renowned faculty of more than 60 scientists, including immunologists, molecular and cell biologists and physicists who investigate cures for blinding eye diseases and aids for victims of low vision. Many diagnostic techniques and devices, surgical methods and medications related to eye diseases were developed by Institute faculty.


Story Source:

The above story is based on materials provided by Schepens Eye Research Institute. Note: Materials may be edited for content and length.


Cite This Page:

Schepens Eye Research Institute. ""Obesity Gene" Causes Cancer Of Fat Tissue, Schepens Scientists Find." ScienceDaily. ScienceDaily, 27 April 2000. <www.sciencedaily.com/releases/2000/04/000427074834.htm>.
Schepens Eye Research Institute. (2000, April 27). "Obesity Gene" Causes Cancer Of Fat Tissue, Schepens Scientists Find. ScienceDaily. Retrieved September 15, 2014 from www.sciencedaily.com/releases/2000/04/000427074834.htm
Schepens Eye Research Institute. ""Obesity Gene" Causes Cancer Of Fat Tissue, Schepens Scientists Find." ScienceDaily. www.sciencedaily.com/releases/2000/04/000427074834.htm (accessed September 15, 2014).

Share This



More Health & Medicine News

Monday, September 15, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

EU Ministers and Experts Meet to Discuss Ebola Reponse

EU Ministers and Experts Meet to Discuss Ebola Reponse

AFP (Sep. 15, 2014) The European Commission met on Monday to coordinate aid that the EU can offer to African countries affected by the Ebola outbreak. Duration: 00:58 Video provided by AFP
Powered by NewsLook.com
FDA Eyes Skin Shocks Used at Mass. School

FDA Eyes Skin Shocks Used at Mass. School

AP (Sep. 15, 2014) The FDA is considering whether to ban devices used by the Judge Rotenberg Educational Center in Canton, Massachusetts, the only place in the country known to use electrical skin shocks as aversive conditioning for aggressive patients. (Sept. 15) Video provided by AP
Powered by NewsLook.com
Respiratory Virus Spreads To Northeast, Now In 21 States

Respiratory Virus Spreads To Northeast, Now In 21 States

Newsy (Sep. 14, 2014) The respiratory virus Enterovirus D68, which targets children, has spread from the Midwest to 21 states. Video provided by Newsy
Powered by NewsLook.com
Shocker: Journalists Are Utterly Addicted To Coffee

Shocker: Journalists Are Utterly Addicted To Coffee

Newsy (Sep. 13, 2014) A U.K. survey found that journalists consumed the most amount of coffee, but that's only the tip of the coffee-related statistics iceberg. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins