Featured Research

from universities, journals, and other organizations

Genes In Blood Vessels May Protect Arteries From The Ravages Of A High-Fat Diet

Date:
July 5, 2000
Source:
American Heart Association
Summary:
Why can some people eat a high-fat diet without developing the fatty deposits in their blood vessel walls that lead to heart disease, and others can't? One answer may be a gene that causes blood vessels to secrete a protective protein, researchers report in Circulation: Journal of the American Heart Association.

DALLAS, July 4, 2000 - Why can some people eat a high-fat diet without developing the fatty deposits in their blood vessel walls that lead to heart disease, and others can't? One answer may be a gene that causes blood vessels to secrete a protective protein, researchers report in today's Circulation: Journal of the American Heart Association.

"The study suggests why some people are prone to blockages in their coronary arteries and some aren't," says Weibin Shi, M.D., Ph.D., a researcher at the University of California, Los Angeles Department of Medicine.

Researchers at UCLA studied cells from the endothelium, or blood vessel lining, of the aortas of two different strains of mice. One strain was a type of mouse that tends to develop atherosclerosis when fed a high-fat diet, while the other type resists developing the disease despite such feeding. The aorta is the body's main artery and carries blood from the left ventricle of the heart to other arteries.

In humans as well as mice, a high fat diet increases blood levels of low-density lipoprotein (LDL), the "bad" cholesterol that at high levels is associated with an increased risk of atherosclerosis. Because the early stages of atherosclerosis are similar in mice and in humans, these findings may hold important implications for humans as well.

Researchers exposed the endothelial cells to mildly oxidized human LDL. Oxidized LDL is known to cause the cells of the endothelium to produce proteins that contribute to atherosclerosis.

After exposure to oxidized LDL, cells from the atherosclerosis-susceptible mice produced proteins that contribute to atherosclerosis, while cells from the atherosclerosis-resistant mice produced a protein called HO-1 that scientists believe inhibits the disease.

"The study has important implications for treatment," Shi says. "We may be able to block the pathways that contribute to the disease, or stimulate others that interrupt it."

In an accompanying editorial, Jan L. Breslow, M.D., of Rockefeller University wrote that the study is the first direct proof that factors in the blood vessel wall, that are independent of diet, are involved in atherosclerosis development.

"These results may provide clues to understanding atherosclerosis susceptibility in humans," Breslow wrote. The study provides a huge boost for atherosclerosis research: a new, previously unknown factor in development of the disease and a new tool with which to study it. It also opens the door for the development of new tests to help determine atherosclerosis susceptibility, and for new treatment methods.

Studies of this newly recognized factor in atherosclerosis susceptibility have yet to be conducted in humans, Shi says.

Co-authors are Margaret E. Haberland, Ph.D.; Ming-Len Jien, B.S.; Diana M. Shih, Ph.D.; and Aldons J. Lusis, Ph.D.


Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


Cite This Page:

American Heart Association. "Genes In Blood Vessels May Protect Arteries From The Ravages Of A High-Fat Diet." ScienceDaily. ScienceDaily, 5 July 2000. <www.sciencedaily.com/releases/2000/07/000705055757.htm>.
American Heart Association. (2000, July 5). Genes In Blood Vessels May Protect Arteries From The Ravages Of A High-Fat Diet. ScienceDaily. Retrieved September 18, 2014 from www.sciencedaily.com/releases/2000/07/000705055757.htm
American Heart Association. "Genes In Blood Vessels May Protect Arteries From The Ravages Of A High-Fat Diet." ScienceDaily. www.sciencedaily.com/releases/2000/07/000705055757.htm (accessed September 18, 2014).

Share This



More Health & Medicine News

Thursday, September 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Cost of Ebola

The Cost of Ebola

Reuters - Business Video Online (Sep. 18, 2014) As Sierra Leone prepares for a three-day "lockdown" in its latest bid to stem the spread of Ebola, Ciara Lee looks at the financial implications of fighting the largest ever outbreak of the disease. Video provided by Reuters
Powered by NewsLook.com
What HealthKit Bug Means For Your iOS Fitness Apps

What HealthKit Bug Means For Your iOS Fitness Apps

Newsy (Sep. 18, 2014) Apple has delayed the launch of the HealthKit app platform, citing a bug. Video provided by Newsy
Powered by NewsLook.com
Residents Vaccinated as Haiti Fights Cholera Epidemic

Residents Vaccinated as Haiti Fights Cholera Epidemic

AFP (Sep. 18, 2014) Haitians receive the second dose of the vaccine against cholera as part of the UN's vaccination campaign. Duration: 00:34 Video provided by AFP
Powered by NewsLook.com
Raw: Elephant Undergoes Surgery in Tbilisi Zoo

Raw: Elephant Undergoes Surgery in Tbilisi Zoo

AP (Sep. 18, 2014) Grand the elephant has successfully undergone surgery to remove a portion of infected tusk at Tbilisi Zoo in Georgia. British veterinary surgeons used an electric drill to extract the infected piece. (Sept. 18) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins