Featured Research

from universities, journals, and other organizations

Clotting Protein May Be Link To Heart Disease

Date:
October 4, 2000
Source:
American Heart Association
Summary:
A little known clotting protein called fibrinogen may be the missing link between heart disease risk factors, such as smoking and high cholesterol, and heart attacks, according to a study in Circulation: Journal of the American Heart Association

DALLAS, Oct. 3 – A little known clotting protein called fibrinogen may be the missing link between heart disease risk factors, such as smoking and high cholesterol, and heart attacks, according to a study in today’s Circulation: Journal of the American Heart Association.

Related Articles


Fibrinogen, a protein produced in the liver, has a pivotal role in the formation of blood clots. A number of factors -– particularly cigarette smoking – increase fibrinogen levels. Higher levels are also seen with advancing age, obesity, physical inactivity and diabetes. Elevated cholesterol is also associated with high fibrinogen, and genetic factors play a role as well.

When subjects in a prior study were divided into three groups, participants with the highest fibrinogen levels were shown to have a 2.3-fold greater risk of coronary disease and heart attack than those in the lowest third.

Here, researchers used a newly developed test called FIF (Functional Intact Fibrinogen) to check fibrinogen levels in 2,632 participants in the Framingham Offspring Study – a continuation of the famed Framingham Heart Study begun more than 50 years ago.

“We not only found fibrinogen levels to be higher in people with heart disease but it also seems to be a common pathway by which other risk factors cause heart disease,” says one of the study’s authors Geoffrey H. Tofler, M.D. a former associate professor at Harvard Medical School, now a professor of cardiology at Royal North Shore Hospital in Sydney, Australia.

Tofler and other scientists at Harvard Medical School and Boston University also measured fibrinogen using an older procedure known as the Clauss Method, in which fibrinogen in a blood sample is converted to fibrin, then timed to determine how long it takes a clot to form. The FIF test, by contrast, uses an antibody, which produces a specific reaction from fibrinogen. This new method may be more adaptable for measuring fibrinogen levels in large populations.

“While our study doesn’t necessarily prove that fibrinogen should be tested routinely as part of a standard physical examination, it does support the argument that measuring fibrinogen provides useful information for assessing an individual patient’s risk,” says Tofler.

“If I’m uncertain about what level of therapy a patient requires -– whether someone should be given a cholesterol-lowering drug, for example – finding high fibrinogen would tend to make me take a more aggressive approach in treatment,” he adds. “Conversely, finding low or normal fibrinogen would reassure me.”

Tofler emphasizes that it’s important for the public to know that the dangers represented by high fibrinogen levels can be reduced in many cases by quitting smoking, losing weight, becoming more physically active and lowering cholesterol through dietary changes and/or medication.

This work was funded in part by the National Institutes of Health and American Biogenetic Sciences.

Co-authors are James J. Stec, B.S.; Halit Silbershatz, Ph.D.; Travis H. Matheney, MLA; Patrice Sutherland, B.S.; Izabela Lipinska, Ph.D.; Joseph M. Massaro, Ph.D.; Peter F. W. Wilson, M.D.; James E. Muller, M.D.; and Ralph B. D’Agostino, Sr., Ph.D.


Story Source:

The above story is based on materials provided by American Heart Association. Note: Materials may be edited for content and length.


Cite This Page:

American Heart Association. "Clotting Protein May Be Link To Heart Disease." ScienceDaily. ScienceDaily, 4 October 2000. <www.sciencedaily.com/releases/2000/10/001003071308.htm>.
American Heart Association. (2000, October 4). Clotting Protein May Be Link To Heart Disease. ScienceDaily. Retrieved February 28, 2015 from www.sciencedaily.com/releases/2000/10/001003071308.htm
American Heart Association. "Clotting Protein May Be Link To Heart Disease." ScienceDaily. www.sciencedaily.com/releases/2000/10/001003071308.htm (accessed February 28, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Saturday, February 28, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could a $34 Smartphone Device Improve HIV Diagnosis in Africa?

Could a $34 Smartphone Device Improve HIV Diagnosis in Africa?

Reuters - Innovations Video Online (Feb. 27, 2015) A dongle that plugs into a Smartphone mimics a lab-based blood test for HIV and syphilis and can detect the diseases in 15 minutes, say researchers. Tara Cleary reports. Video provided by Reuters
Powered by NewsLook.com
Doctor Says Head Transplants Possible Within Two Years

Doctor Says Head Transplants Possible Within Two Years

Buzz60 (Feb. 27, 2015) An Italian doctor is saying he could stick someone&apos;s head onto someone else&apos;s body. Patrick Jones (@Patrick_E_Jones) reports. Video provided by Buzz60
Powered by NewsLook.com
How Your Dentist Could Help Screen You For Diabetes

How Your Dentist Could Help Screen You For Diabetes

Newsy (Feb. 27, 2015) A new study from researchers at New York University suggests dentists could soon use blood samples taken from patients&apos; mouths to test for diabetes. Video provided by Newsy
Powered by NewsLook.com
The Best Tips to Makeover Your Health

The Best Tips to Makeover Your Health

Buzz60 (Feb. 27, 2015) If you&apos;re looking to boost your health this season, there are a few quick and easy steps to prompt you for success. Krystin Goodwin (@Krystingoodwin) has the best tips to give your health a makeover this spring! Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins