Featured Research

from universities, journals, and other organizations

University Of Kentucky Research Study: Dietary Supplement Creatine Protects Against Traumatic Brain Injury

Date:
November 9, 2000
Source:
University Of Kentucky Medical Center
Summary:
Creatine, a food supplement frequently used by professional and amateur athletes, may prevent brain damage following traumatic brain injury, according to a new research study led by Stephen Scheff, Ph.D., professor, University of Kentucky Sanders-Brown Center on Aging and UK College of Medicine Department of Anatomy and Neurobiology.

LEXINGTON, KY (Nov. 2, 2000) - Creatine, a food supplement frequently used by professional and amateur athletes, may prevent brain damage following traumatic brain injury, according to a new research study led by Stephen Scheff, Ph.D., professor, University of Kentucky Sanders-Brown Center on Aging and UK College of Medicine Department of Anatomy and Neurobiology. The study was published in the November issue of Annals of Neurology.

Creatine is one of a class of molecules called amino acids. Creatine is produced naturally in the body in the liver, kidney and pancreas and is used as a way to store energy.

Many athletes now use creatine as a dietary supplement to increase muscle mass, strength, and the recovery time of muscles between bursts of activity.

Each year about 7 million people in North America experience traumatic brain injuries (TBI) caused by motor vehicle accidents, falls, assaults and sports-related activities. Estimated costs to treat these injuries range from $20 billion to $48 billion each year.

According to the Centers for Disease Control and Prevention, about 300,000 TBIs occur each year due to sports or recreational activities. Athletes, especially those participating in sports that are likely to involve blows to the head such as football, hockey, wrestling, skiing, baseball and boxing, often experience TBIs. Most of these TBIs are concussions. These concussions can result in subdural hematomas (bleeding under a membrane surrounding the brain), loss of cognitive function or even death.

TBI causes both primary and secondary damage. The primary damage occurs at the time of injury as a result of the trauma. Secondary damage develops following the injury and can occur as long as days after the initial trauma.

The cause of the secondary injury is not well understood, but appears to be associated with disruption of the regulation of calcium levels in brain cells following injury. Regulation of calcium levels is crucial to mitochondrial function and to proper adenosine triphosphate (ATP) synthesis and use. ATP is a molecule that is present in all living cells and operates as the energy source for the majority of the chemical reactions which take place in cells.

Scheff's research team demonstrated that brain damage in mice was reduced 21 percent and 36 percent when creatine was administered three and five days before the TBI respectively. The data also show that in rats fed a diet supplemented with creatine for four weeks before TBI, brain damage was reduced 50 percent when compared to rats fed a regular diet.

"Our data show that creatine supplementation protects against secondary damage associated with TBI by inhibiting the calcium-induced activation of a protein in the mitochondrial membrane, which preserves proper function of the mitochondria. The damage also is reduced because creatine acts to maintain appropriate amounts of ATP in brain cells," Scheff said.

"This strongly suggests that athletes may be gaining a neuroprotective benefit inadvertently by chronically supplementing their diet with creatine," Scheff said.


Story Source:

The above story is based on materials provided by University Of Kentucky Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

University Of Kentucky Medical Center. "University Of Kentucky Research Study: Dietary Supplement Creatine Protects Against Traumatic Brain Injury." ScienceDaily. ScienceDaily, 9 November 2000. <www.sciencedaily.com/releases/2000/11/001102071632.htm>.
University Of Kentucky Medical Center. (2000, November 9). University Of Kentucky Research Study: Dietary Supplement Creatine Protects Against Traumatic Brain Injury. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2000/11/001102071632.htm
University Of Kentucky Medical Center. "University Of Kentucky Research Study: Dietary Supplement Creatine Protects Against Traumatic Brain Injury." ScienceDaily. www.sciencedaily.com/releases/2000/11/001102071632.htm (accessed September 23, 2014).

Share This



More Health & Medicine News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Liberia Pleads for Help to Fight Ebola

Liberia Pleads for Help to Fight Ebola

AP (Sep. 22, 2014) Liberia's finance minister is urging the international community to quickly follow through on pledges of cash to battle Ebola. Bodies are piling up in the capital Monrovia as the nation awaits more help. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Ebola Doctor Says Border Controls Critical

Ebola Doctor Says Border Controls Critical

AP (Sep. 22, 2014) A Florida doctor who helped fight the expanding Ebola outbreak in West Africa says the disease can be stopped, but only if nations quickly step up their response and make border control a priority. (Sept. 22) Video provided by AP
Powered by NewsLook.com
Global Ebola Aid Increasing But Critics Say It's Late

Global Ebola Aid Increasing But Critics Say It's Late

Newsy (Sep. 21, 2014) More than 100 tons of medical supplies were sent to West Africa on Saturday, but aid workers say the global response is still sluggish. Video provided by Newsy
Powered by NewsLook.com
Sierra Leone in Lockdown to Control Ebola

Sierra Leone in Lockdown to Control Ebola

AP (Sep. 21, 2014) Sierra Leone residents remained in lockdown on Saturday as part of a massive effort to confine millions of people to their homes in a bid to stem the biggest Ebola outbreak in history. (Sept. 20) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins