November 9, 2000
Cold Spring Harbor Laboratory
Bruce Stillman and his colleagues at Cold Spring Harbor Laboratory have demonstrated how a set of proteins work in concert to duplicate both the basic sequence of DNA as well as silenced states of chromatin structure. The findings, published this week in Nature, provide the first detailed mechanism to explain how both DNA sequences and their associated states of gene expression are coordinately passed on to future generations of cells.
Cold Spring Harbor, NY (Nov. 8, 2000) -- As genetically identical cells (such as those in an embryo) multiply, different sets of genes are switched on, and others off, giving rise to cells and tissues with distinctive properties (e.g. liver versus muscle). Such differential gene expression is determined in part by the large-scale architecture or chromatin structure of DNA. "Silent" regions of DNA are tightly packaged into forms of chromatin that are less accessible to transcriptional activators, the proteins that switch genes on. Active regions of DNA adopt alternate chromatin structures that are generally more accessible to transcriptional activators .
The above story is based on materials provided by Cold Spring Harbor Laboratory. Note: Materials may be edited for content and length.
Cite This Page:
Cold Spring Harbor Laboratory. "The Silence Of The Clones: New Link Between DNA Replication And "Silent" Chromosome Architecture." ScienceDaily. ScienceDaily, 9 November 2000. <www.sciencedaily.com/releases/2000/11/001109081220.htm>.
Cold Spring Harbor Laboratory. (2000, November 9). The Silence Of The Clones: New Link Between DNA Replication And "Silent" Chromosome Architecture. ScienceDaily. Retrieved April 19, 2014 from www.sciencedaily.com/releases/2000/11/001109081220.htm
Cold Spring Harbor Laboratory. "The Silence Of The Clones: New Link Between DNA Replication And "Silent" Chromosome Architecture." ScienceDaily. www.sciencedaily.com/releases/2000/11/001109081220.htm (accessed April 19, 2014).